Chronic Glucocorticoids Increase Hippocampal Vulnerability to Neurotoxicity under Conditions That Produce CA3 Dendritic Retraction But Fail to Impair Spatial Recognition Memory

• Published in: The Journal of neuroscience Vol. 27; no. 31; pp. 8278 - 8285
• Main Authors: Conrad, Cheryl D, McLaughlin, Katie J, Harman, James S, Foltz, Cainan, Wieczorek, Lindsay, Lightner, Elizabeth, Wright, Ryan L
• Format: Journal Article
• Language: English
• Published: United States Soc Neuroscience 01.08.2007; Society for Neuroscience
• Subjects: Animals; Dendrites - drug effects; Dendrites - physiology; Glucocorticoids - administration & dosage; Glucocorticoids - blood; Hippocampus - cytology; Hippocampus - drug effects; Hippocampus - physiology; Ibotenic Acid - toxicity; Male; Memory - drug effects; Memory - physiology; Rats; Rats, Sprague-Dawley; Recognition, Psychology - drug effects; Recognition, Psychology - physiology; Spatial Behavior - drug effects; Spatial Behavior - physiology

We previously found that chronic stress conditions producing CA3 dendritic retraction and spatial memory deficits make the hippocampus vulnerable to the neurotoxin ibotenic acid (IBO). The purpose of this study was to determine whether exposure to chronic corticosterone (CORT) under conditions that...