A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease

• Published in: Nature immunology Vol. 25; no. 11; pp. 2152 - 2165
• Main Authors: Thomas, Tom, Friedrich, Matthias, Rich-Griffin, Charlotte, Pohin, Mathilde, Agarwal, Devika, Pakpoor, Julia, Lee, Carl, Tandon, Ruchi, Rendek, Aniko, Aschenbrenner, Dominik, Jainarayanan, Ashwin, Voda, Alexandru, Siu, Jacqueline H. Y., Sanches-Peres, Raphael, Nee, Eloise, Sathananthan, Dharshan, Kotliar, Dylan, Todd, Peter, Kiourlappou, Maria, Gartner, Lisa, Ilott, Nicholas, Issa, Fadi, Hester, Joanna, Turner, Jason, Nayar, Saba, Mackerodt, Jonas, Zhang, Fan, Jonsson, Anna, Brenner, Michael, Raychaudhuri, Soumya, Kulicke, Ruth, Ramsdell, Danielle, Stransky, Nicolas, Pagliarini, Ray, Bielecki, Piotr, Spies, Noah, Marsden, Brian, Taylor, Stephen, Wagner, Allon, Klenerman, Paul, Walsh, Alissa, Coles, Mark, Jostins-Dean, Luke, Powrie, Fiona M., Filer, Andrew, Travis, Simon, Uhlig, Holm H., Dendrou, Calliope A., Buckley, Christopher D.
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.11.2024; Nature Publishing Group
• Subjects: 631/250/249/2510/257/1402; 692/699/249/2510/2511; Adalimumab - therapeutic use; Adult; Arthritis, Rheumatoid - drug therapy; Arthritis, Rheumatoid - immunology; Biological treatment; Biomedical and Life Sciences; Biomedicine; Biopsy; Colitis, Ulcerative - drug therapy; Colitis, Ulcerative - immunology; Crohn Disease - drug therapy; Crohn Disease - immunology; Crohn's disease; Female; Granuloma; Humans; Immunology; Infectious Diseases; Inflammatory bowel disease; Inflammatory bowel diseases; Inflammatory Bowel Diseases - drug therapy; Inflammatory Bowel Diseases - immunology; Inflammatory diseases; Interferon; Interferons - metabolism; Longitudinal Studies; Lymphocytes T; Male; Medical treatment; Monoclonal antibodies; Precision medicine; Remission; Remission (Medicine); Resource; Rheumatoid arthritis; Rheumatoid synovitis; Signal Transduction; Single-Cell Analysis; Spatial analysis; Transcriptome; Transcriptomes; Tumor necrosis factor; Tumor Necrosis Factor-alpha - antagonists & inhibitors; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-TNF; Tumors; Ulcerative colitis

Precision medicine in immune-mediated inflammatory diseases (IMIDs) requires a cellular understanding of treatment response. We describe a therapeutic atlas for Crohn’s disease (CD) and ulcerative colitis (UC) following adalimumab, an anti-tumour necrosis factor (anti-TNF) treatment. We generated ~1...