Non-neutral evolution and reciprocal monophyly of two expressed Mhc class II B genes in Leach’s storm-petrel

• Published in: Immunogenetics (New York) Vol. 67; no. 2; pp. 111 - 123
• Main Authors: Dearborn, Donald C., Gager, Andrea B., Gilmour, Morgan E., McArthur, Andrew G., Hinerfeld, Douglas A., Mauck, Robert A.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.02.2015; Springer Nature B.V
• Subjects: Allergology; Amino Acid Sequence; Amino acids; Animals; Avian Proteins - genetics; Avian Proteins - immunology; Base Sequence; Binding sites; Biomedical and Life Sciences; Biomedicine; Birds; Birds - genetics; Birds - immunology; Cell Biology; DNA - genetics; Evolution; Evolution, Molecular; Exons; Female; Gene Conversion; Gene Duplication; Gene Function; Genes; Genes, MHC Class II; Genetic Variation; Genotypes; Histocompatibility Antigens Class II - genetics; Human Genetics; Immunology; Male; Molecular Sequence Data; Mutation; Oceanodroma leucorhoa; Original Paper; Pathogens; Peptides; Phylogenetics; Phylogeny; Selection, Genetic; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; United States > US; Seabirds; Gene duplication; Major histocompatibility complex; Gene conversion; Positive selection; Peptide binding site

The major histocompatibility complex (Mhc) is subject to pathogen-mediated balancing selection and can link natural selection with mate choice. We characterized two Mhc class II B loci in Leach’s storm-petrel, Oceanodroma leucorhoa , focusing on exon 2 which encodes the portion of the protein that b...