DNA-PKcs Ser2056 auto-phosphorylation is affected by an O-GlcNAcylation/phosphorylation interplay

• Published in: Biochimica et biophysica acta. General subjects Vol. 1864; no. 12; p. 129705
• Main Authors: Lafont, Florian, Fleury, Fabrice, Benhelli-Mokrani, Houda
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2020; Elsevier
• Subjects: Acetylglucosamine - metabolism; Acylation; DNA; DNA damage; DNA repair; DNA-Activated Protein Kinase - metabolism; DNA-PKcs; genome; HeLa Cells; human cell lines; Humans; Life Sciences; NHEJ; O-GlcNAcylation; Phosphorylation; post-translational modification; protein kinases; Protein Processing, Post-Translational; protein subunits; telomeres; DNA-PKcs; O-GlcNAcylation; Phosphorylation; HR; NHEJ; DNA repair

DNA dependent Protein Kinase (DNA-PK) is an heterotrimeric complex regulating the Non Homologous End Joining (NHEJ) double strand break (DSB) repair pathway. The activity of its catalytic subunit (DNA-PKcs) is regulated by multiple phosphorylations, like the Ser2056 one that impacts DSB end processi...