Alpha-melanocyte-stimulating hormone protects against renal injury after ischemia in mice and rats

• Published in: The Journal of clinical investigation Vol. 99; no. 6; pp. 1165 - 1172
• Main Authors: Chiao, H, Kohda, Y, McLeroy, P, Craig, L, Housini, I, Star, R A
• Format: Journal Article
• Language: English
• Published: United States 15.03.1997
• Subjects: alpha-MSH - administration & dosage; alpha-MSH - pharmacology; Animals; Blotting, Northern; Cell Adhesion Molecules - genetics; Chemokines - genetics; Drug Administration Schedule; Female; Kidney - blood supply; Kidney - drug effects; Kidney - pathology; Male; Mice; Mice, Inbred BALB C; Nitrates - metabolism; Nitric Oxide Synthase - biosynthesis; Rats; Rats, Sprague-Dawley; Reperfusion Injury - drug therapy; Reperfusion Injury - metabolism; Reperfusion Injury - pathology; RNA, Messenger - analysis

Reperfusion after ischemia induces cytokines, chemoattractant chemokines, adhesion molecules, and nitric oxide (NO). The resultant neutrophil adherence and NO potentiates renal injury. alpha-Melanocyte-stimulating hormone (alpha-MSH) is a potent anti-inflammatory agent that inhibits neutrophil migra...