Computational Modeling of the Subject-Specific Effects of Annuloplasty Ring Sizing on the Mitral Valve to Repair Functional Mitral Regurgitation

• Published in: Annals of biomedical engineering Vol. 51; no. 9; pp. 1984 - 2000
• Main Authors: Gaidulis, Gediminas, Padala, Muralidhar
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.09.2023; Springer Nature B.V
• Subjects: Animals; Biochemistry; Biological and Medical Physics; Biomedical and Life Sciences; Biomedical engineering; Biomedical Engineering and Bioengineering; Biomedicine; Biophysics; Classical Mechanics; Computer applications; Computer Simulation; Congestive heart failure; Geometry; Heart Failure; Heart Valve Prosthesis; Heart valves; Heterogeneity; Mathematical models; Mitral valve; Mitral Valve - diagnostic imaging; Mitral Valve - surgery; Mitral Valve Insufficiency - diagnostic imaging; Mitral Valve Insufficiency - surgery; Original Article; Patients; Prediction models; Regurgitation; Surgery; Swine; Tethering; Three dimensional models; Vascular implants; Finite element method; Mitral regurgitation; Mitral valve; Computational modeling; Cardiac mechanics; Mitral annuloplasty

Surgical repair of functional mitral regurgitation (FMR) that occurs in nearly 60% of heart failure (HF) patients is currently performed with undersizing mitral annuloplasty (UMA), which lacks short- and long-term durability. Heterogeneity in valve geometry makes tailoring this repair to each patien...