IL-10 constrains sphingolipid metabolism to limit inflammation - York, Autumn G.; Skadow, Mathias H.; Oh, Joonseok; Qu, Rihao; Zhou, Quan D.; Hsieh, Wei-Yuan; Mowel, Walter K.; Brewer, J. Richard; Kaffe, Eleanna; Williams, Kevin J.; Kluger, Yuval; Smale, Stephen T.; et al. (Nature (London), 2024)
Keywords: 38; 38/91; 631/250/256/2515; 631/250/262/2106/2108; 631/250/347; 631/45/287/1196; 631/45/608; 64/60; 82; 82/1; 96; 96/21; 96/31; Accumulation; Animals; Cell activation; Ceramide; Ceramides - chemistry; Ceramides - metabolism; Cytokines; Desaturation; Fatty acids; Fatty Acids, Unsaturated - biosynthesis; Fatty Acids, Unsaturated - metabolism; Gene deletion; Gene expression; Homeostasis; Humanities and Social Sciences; Humans; Immune system; Immunity, Innate; Inflammation; Inflammation - genetics; Inflammation - metabolism; Inflammation - pathology; Inflammatory bowel disease; Inflammatory bowel diseases; Interleukin 10; Interleukin-10 - deficiency; Interleukin-10 - genetics; Interleukin-10 - metabolism; Lipid metabolism; Lipids; Metabolic flux; Metabolism; Metabolites; Mice; multidisciplinary; Proto-Oncogene Proteins c-rel; Science; Science (multidisciplinary); Signal transduction; Sphingolipids - metabolism; Transcription factors