Prenatal exposure to per- and polyfluoroalkyl substances and early childhood adiposity and cardiometabolic health in the Healthy Start study
Background/Objectives Observational and experimental studies have suggested that prenatal exposure to per- and polyfluoroalkyl substances (PFAS) can increase childhood adiposity and cardiometabolic disruption. However, most previous studies have used weight-based measures that cannot distinguish bet...
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| Published in | International Journal of Obesity Vol. 48; no. 2; pp. 276 - 283 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
01.02.2024
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Background/Objectives
Observational and experimental studies have suggested that prenatal exposure to per- and polyfluoroalkyl substances (PFAS) can increase childhood adiposity and cardiometabolic disruption. However, most previous studies have used weight-based measures that cannot distinguish between fat mass and lean mass. We evaluated associations of prenatal PFAS exposure with precisely measured body composition and cardiometabolic biomarkers in early childhood.
Subjects
373 eligible mother-infant pairs in the Healthy Start longitudinal cohort.
Methods
We used multiple linear regression and Bayesian kernel machine regression models to estimate associations between five PFAS in maternal mid-pregnancy serum, and early childhood adiposity via air displacement plethysmography. Secondary outcomes included body mass index, waist circumference, and fasting serum lipids, glucose, insulin and adipokines. Models were adjusted for potential confounders and effect modification by child sex was evaluated.
Results
The median age of children at assessment was 4.6 years. Prenatal concentration of perfluorooctanoate (PFOA) was positively associated with percent fat mass (0.89% per log
2
-unit increase, 95% CI: 0.15, 1.64), while perfluorononanoate (PFNA) was positively associated with fat mass index and body mass index. Cardiometabolic markers in blood were generally not associated with prenatal PFAS in this population. Mixture models confirmed the importance of PFNA and PFOA in predicting percent fat mass, while PFNA was most important for fat mass index, body mass index, and waist circumference. There were no significant effects of the five PFAS as a mixture, potentially due to opposing effects of different PFAS.
Conclusions
Our results agree with previous studies showing that prenatal serum concentrations of certain PFAS are positively associated with early childhood adiposity. Notably, associations were stronger for measures incorporating precisely measured fat mass compared to measures of body size or weight. Early life increases in adiposity may precede the development of adverse cardiometabolic health outcomes in children exposed to PFAS during gestation. |
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| AbstractList | Background/ObjectivesObservational and experimental studies have suggested that prenatal exposure to per- and polyfluoroalkyl substances (PFAS) can increase childhood adiposity and cardiometabolic disruption. However, most previous studies have used weight-based measures that cannot distinguish between fat mass and lean mass. We evaluated associations of prenatal PFAS exposure with precisely measured body composition and cardiometabolic biomarkers in early childhood.Subjects373 eligible mother-infant pairs in the Healthy Start longitudinal cohort.MethodsWe used multiple linear regression and Bayesian kernel machine regression models to estimate associations between five PFAS in maternal mid-pregnancy serum, and early childhood adiposity via air displacement plethysmography. Secondary outcomes included body mass index, waist circumference, and fasting serum lipids, glucose, insulin and adipokines. Models were adjusted for potential confounders and effect modification by child sex was evaluated.ResultsThe median age of children at assessment was 4.6 years. Prenatal concentration of perfluorooctanoate (PFOA) was positively associated with percent fat mass (0.89% per log2-unit increase, 95% CI: 0.15, 1.64), while perfluorononanoate (PFNA) was positively associated with fat mass index and body mass index. Cardiometabolic markers in blood were generally not associated with prenatal PFAS in this population. Mixture models confirmed the importance of PFNA and PFOA in predicting percent fat mass, while PFNA was most important for fat mass index, body mass index, and waist circumference. There were no significant effects of the five PFAS as a mixture, potentially due to opposing effects of different PFAS.ConclusionsOur results agree with previous studies showing that prenatal serum concentrations of certain PFAS are positively associated with early childhood adiposity. Notably, associations were stronger for measures incorporating precisely measured fat mass compared to measures of body size or weight. Early life increases in adiposity may precede the development of adverse cardiometabolic health outcomes in children exposed to PFAS during gestation. Observational and experimental studies have suggested that prenatal exposure to per- and polyfluoroalkyl substances (PFAS) can increase childhood adiposity and cardiometabolic disruption. However, most previous studies have used weight-based measures that cannot distinguish between fat mass and lean mass. We evaluated associations of prenatal PFAS exposure with precisely measured body composition and cardiometabolic biomarkers in early childhood. 373 eligible mother-infant pairs in the Healthy Start longitudinal cohort. We used multiple linear regression and Bayesian kernel machine regression models to estimate associations between five PFAS in maternal mid-pregnancy serum, and early childhood adiposity via air displacement plethysmography. Secondary outcomes included body mass index, waist circumference, and fasting serum lipids, glucose, insulin and adipokines. Models were adjusted for potential confounders and effect modification by child sex was evaluated. The median age of children at assessment was 4.6 years. Prenatal concentration of perfluorooctanoate (PFOA) was positively associated with percent fat mass (0.89% per log -unit increase, 95% CI: 0.15, 1.64), while perfluorononanoate (PFNA) was positively associated with fat mass index and body mass index. Cardiometabolic markers in blood were generally not associated with prenatal PFAS in this population. Mixture models confirmed the importance of PFNA and PFOA in predicting percent fat mass, while PFNA was most important for fat mass index, body mass index, and waist circumference. There were no significant effects of the five PFAS as a mixture, potentially due to opposing effects of different PFAS. Our results agree with previous studies showing that prenatal serum concentrations of certain PFAS are positively associated with early childhood adiposity. Notably, associations were stronger for measures incorporating precisely measured fat mass compared to measures of body size or weight. Early life increases in adiposity may precede the development of adverse cardiometabolic health outcomes in children exposed to PFAS during gestation. Observational and experimental studies have suggested that prenatal exposure to per- and polyfluoroalkyl substances (PFAS) can increase childhood adiposity and cardiometabolic disruption. However, most previous studies have used weight-based measures that cannot distinguish between fat mass and lean mass. We evaluated associations of prenatal PFAS exposure with precisely measured body composition and cardiometabolic biomarkers in early childhood.BACKGROUND/OBJECTIVESObservational and experimental studies have suggested that prenatal exposure to per- and polyfluoroalkyl substances (PFAS) can increase childhood adiposity and cardiometabolic disruption. However, most previous studies have used weight-based measures that cannot distinguish between fat mass and lean mass. We evaluated associations of prenatal PFAS exposure with precisely measured body composition and cardiometabolic biomarkers in early childhood.373 eligible mother-infant pairs in the Healthy Start longitudinal cohort.SUBJECTS373 eligible mother-infant pairs in the Healthy Start longitudinal cohort.We used multiple linear regression and Bayesian kernel machine regression models to estimate associations between five PFAS in maternal mid-pregnancy serum, and early childhood adiposity via air displacement plethysmography. Secondary outcomes included body mass index, waist circumference, and fasting serum lipids, glucose, insulin and adipokines. Models were adjusted for potential confounders and effect modification by child sex was evaluated.METHODSWe used multiple linear regression and Bayesian kernel machine regression models to estimate associations between five PFAS in maternal mid-pregnancy serum, and early childhood adiposity via air displacement plethysmography. Secondary outcomes included body mass index, waist circumference, and fasting serum lipids, glucose, insulin and adipokines. Models were adjusted for potential confounders and effect modification by child sex was evaluated.The median age of children at assessment was 4.6 years. Prenatal concentration of perfluorooctanoate (PFOA) was positively associated with percent fat mass (0.89% per log2-unit increase, 95% CI: 0.15, 1.64), while perfluorononanoate (PFNA) was positively associated with fat mass index and body mass index. Cardiometabolic markers in blood were generally not associated with prenatal PFAS in this population. Mixture models confirmed the importance of PFNA and PFOA in predicting percent fat mass, while PFNA was most important for fat mass index, body mass index, and waist circumference. There were no significant effects of the five PFAS as a mixture, potentially due to opposing effects of different PFAS.RESULTSThe median age of children at assessment was 4.6 years. Prenatal concentration of perfluorooctanoate (PFOA) was positively associated with percent fat mass (0.89% per log2-unit increase, 95% CI: 0.15, 1.64), while perfluorononanoate (PFNA) was positively associated with fat mass index and body mass index. Cardiometabolic markers in blood were generally not associated with prenatal PFAS in this population. Mixture models confirmed the importance of PFNA and PFOA in predicting percent fat mass, while PFNA was most important for fat mass index, body mass index, and waist circumference. There were no significant effects of the five PFAS as a mixture, potentially due to opposing effects of different PFAS.Our results agree with previous studies showing that prenatal serum concentrations of certain PFAS are positively associated with early childhood adiposity. Notably, associations were stronger for measures incorporating precisely measured fat mass compared to measures of body size or weight. Early life increases in adiposity may precede the development of adverse cardiometabolic health outcomes in children exposed to PFAS during gestation.CONCLUSIONSOur results agree with previous studies showing that prenatal serum concentrations of certain PFAS are positively associated with early childhood adiposity. Notably, associations were stronger for measures incorporating precisely measured fat mass compared to measures of body size or weight. Early life increases in adiposity may precede the development of adverse cardiometabolic health outcomes in children exposed to PFAS during gestation. Background/Objectives Observational and experimental studies have suggested that prenatal exposure to per- and polyfluoroalkyl substances (PFAS) can increase childhood adiposity and cardiometabolic disruption. However, most previous studies have used weight-based measures that cannot distinguish between fat mass and lean mass. We evaluated associations of prenatal PFAS exposure with precisely measured body composition and cardiometabolic biomarkers in early childhood. Subjects 373 eligible mother-infant pairs in the Healthy Start longitudinal cohort. Methods We used multiple linear regression and Bayesian kernel machine regression models to estimate associations between five PFAS in maternal mid-pregnancy serum, and early childhood adiposity via air displacement plethysmography. Secondary outcomes included body mass index, waist circumference, and fasting serum lipids, glucose, insulin and adipokines. Models were adjusted for potential confounders and effect modification by child sex was evaluated. Results The median age of children at assessment was 4.6 years. Prenatal concentration of perfluorooctanoate (PFOA) was positively associated with percent fat mass (0.89% per log 2 -unit increase, 95% CI: 0.15, 1.64), while perfluorononanoate (PFNA) was positively associated with fat mass index and body mass index. Cardiometabolic markers in blood were generally not associated with prenatal PFAS in this population. Mixture models confirmed the importance of PFNA and PFOA in predicting percent fat mass, while PFNA was most important for fat mass index, body mass index, and waist circumference. There were no significant effects of the five PFAS as a mixture, potentially due to opposing effects of different PFAS. Conclusions Our results agree with previous studies showing that prenatal serum concentrations of certain PFAS are positively associated with early childhood adiposity. Notably, associations were stronger for measures incorporating precisely measured fat mass compared to measures of body size or weight. Early life increases in adiposity may precede the development of adverse cardiometabolic health outcomes in children exposed to PFAS during gestation. |
| Author | Dabelea, Dana Adgate, John L. Friedman, Chloe Allshouse, William B. Glueck, Deborah H. Bloemsma, Lizan D. Starling, Anne P. Boyle, Kristen E. Calafat, Antonia M. |
| AuthorAffiliation | 4 Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA 5 Department of Environmental and Occupational Health, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA 1 Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, NC, USA 2 Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA 3 Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA 6 Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA |
| AuthorAffiliation_xml | – name: 2 Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA – name: 3 Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA – name: 5 Department of Environmental and Occupational Health, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA – name: 6 Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA – name: 4 Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA – name: 1 Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, NC, USA |
| Author_xml | – sequence: 1 givenname: Anne P. orcidid: 0000-0002-6638-8314 surname: Starling fullname: Starling, Anne P. email: anne.starling@unc.edu organization: Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus – sequence: 2 givenname: Chloe orcidid: 0000-0002-3660-5373 surname: Friedman fullname: Friedman, Chloe organization: Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus – sequence: 3 givenname: Kristen E. orcidid: 0000-0001-9689-3322 surname: Boyle fullname: Boyle, Kristen E. organization: Department of Pediatrics, University of Colorado Anschutz Medical Campus – sequence: 4 givenname: John L. surname: Adgate fullname: Adgate, John L. organization: Department of Environmental and Occupational Health, Colorado School of Public Health, University of Colorado Anschutz Medical Campus – sequence: 5 givenname: Deborah H. surname: Glueck fullname: Glueck, Deborah H. organization: Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Department of Pediatrics, University of Colorado Anschutz Medical Campus – sequence: 6 givenname: William B. orcidid: 0000-0002-8763-9194 surname: Allshouse fullname: Allshouse, William B. organization: Department of Environmental and Occupational Health, Colorado School of Public Health, University of Colorado Anschutz Medical Campus – sequence: 7 givenname: Antonia M. surname: Calafat fullname: Calafat, Antonia M. organization: Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention – sequence: 8 givenname: Lizan D. orcidid: 0000-0001-9941-8551 surname: Bloemsma fullname: Bloemsma, Lizan D. organization: Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus – sequence: 9 givenname: Dana surname: Dabelea fullname: Dabelea, Dana organization: Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Department of Pediatrics, University of Colorado Anschutz Medical Campus |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38042932$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_envres_2025_121330 crossref_primary_10_3345_cep_2024_00556 crossref_primary_10_3390_toxics12100732 crossref_primary_10_1016_j_envint_2024_109206 |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 APS, JLA, KEB, and DD conceived of the study. APS designed and conducted the statistical analyses and wrote the first draft of the manuscript. CF and LDB contributed to the definition of the early childhood outcomes and provided critical feedback on the manuscript. DHG and WBA provided subject-matter expertise and critical feedback on the manuscript. AMC oversaw the quantification of PFAS in maternal serum and provided critical feedback on the manuscript. All authors read and approved the final version of the manuscript prior to submission. Author contributions |
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Observational and experimental studies have suggested that prenatal exposure to per- and polyfluoroalkyl substances (PFAS) can increase... Observational and experimental studies have suggested that prenatal exposure to per- and polyfluoroalkyl substances (PFAS) can increase childhood adiposity and... Background/ObjectivesObservational and experimental studies have suggested that prenatal exposure to per- and polyfluoroalkyl substances (PFAS) can increase... |
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| SubjectTerms | 692/308/174 692/499 Adipose tissue Adiposity Bayes Theorem Bayesian analysis Biomarkers Body composition Body fat Body mass index Body size Body weight Caprylates Cardiovascular Diseases - chemically induced Child Child, Preschool Childhood Children Environmental Pollutants Epidemiology Evaluation Exposure Female Fluorocarbons Health Promotion and Disease Prevention Humans Internal Medicine Lipids Mathematical models Medicine Medicine & Public Health Metabolic Diseases Mixtures Pediatric Obesity - chemically induced Pediatric Obesity - epidemiology Perfluoroalkyl & polyfluoroalkyl substances Perfluorochemicals Perfluorooctanoic acid Plethysmography Pregnancy Prenatal experience Prenatal exposure Prenatal Exposure Delayed Effects - chemically induced Public Health Regression analysis Regression models Serum lipids |
| Title | Prenatal exposure to per- and polyfluoroalkyl substances and early childhood adiposity and cardiometabolic health in the Healthy Start study |
| URI | https://link.springer.com/article/10.1038/s41366-023-01420-3 https://www.ncbi.nlm.nih.gov/pubmed/38042932 https://www.proquest.com/docview/2919765568 https://www.proquest.com/docview/2896805883 https://pubmed.ncbi.nlm.nih.gov/PMC10872497 |
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