Intrinsic brain functional connectivity predicts treatment-related motor complications in early Parkinson’s disease patients

• Published in: Journal of neurology Vol. 271; no. 2; pp. 826 - 834
• Main Authors: De Micco, Rosa, Di Nardo, Federica, Siciliano, Mattia, Silvestro, Marcello, Russo, Antonio, Cirillo, Mario, Tedeschi, Gioacchino, Esposito, Fabrizio, Tessitore, Alessandro
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.02.2024; Springer Nature B.V
• Subjects: Brain; Brain - diagnostic imaging; Brain Mapping - methods; Clinical trials; Dopamine; Dopamine receptors; Frontal gyrus; Humans; Magnetic Resonance Imaging - methods; Medicine; Medicine & Public Health; Movement disorders; Neural networks; Neurodegeneration; Neurodegenerative diseases; Neurology; Neuroradiology; Neurosciences; Original Communication; Parkinson Disease - complications; Parkinson Disease - diagnostic imaging; Parkinson Disease - drug therapy; Parkinson's disease; Patients; Sensorimotor system; Drug-naïve; Treatment-related complications; MRI; Parkinson’s disease; Resting-state connectivity

Background Treatment-related motor complications may develop progressively over the course of Parkinson’s disease (PD). Objective We investigated intrinsic brain networks functional connectivity (FC) at baseline in a cohort of early PD patients which successively developed treatment-related motor co...