Mucosal adenovirus vaccine boosting elicits IgA and durably prevents XBB.1.16 infection in nonhuman primates

• Published in: Nature immunology Vol. 25; no. 10; pp. 1913 - 1927
• Main Authors: Gagne, Matthew, Flynn, Barbara J., Andrew, Shayne F., Marquez, Josue, Flebbe, Dillon R., Mychalowych, Anna, Lamb, Evan, Davis-Gardner, Meredith E., Burnett, Matthew R., Serebryannyy, Leonid A., Lin, Bob C., Ziff, Zohar E., Maule, Erin, Carroll, Robin, Naisan, Mursal, Jethmalani, Yogita, Pessaint, Laurent, Todd, John-Paul M., Doria-Rose, Nicole A., Case, James Brett, Dmitriev, Igor P., Kashentseva, Elena A., Ying, Baoling, Dodson, Alan, Kouneski, Katelyn, O’Dell, Sijy, Wali, Bushra, Ellis, Madison, Godbole, Sucheta, Laboune, Farida, Henry, Amy R., Teng, I-Ting, Wang, Danyi, Wang, Lingshu, Zhou, Qiong, Zouantchangadou, Serge, Van Ry, Alex, Lewis, Mark G., Andersen, Hanne, Kwong, Peter D., Curiel, David T., Roederer, Mario, Nason, Martha C., Foulds, Kathryn E., Suthar, Mehul S., Diamond, Michael S., Douek, Daniel C., Seder, Robert A.
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.10.2024; Nature Publishing Group
• Subjects: 631/250/2152/2153/1571; 631/250/347; 631/250/590/1867; 631/326/590/1867; 631/326/596/4130; Adenoviridae - genetics; Adenoviridae - immunology; Adenovirus Vaccines - administration & dosage; Adenovirus Vaccines - immunology; Administration, Intranasal; Animals; Antibodies, Neutralizing - blood; Antibodies, Neutralizing - immunology; Antibodies, Viral - blood; Antibodies, Viral - immunology; B-Lymphocytes - immunology; Biomedical and Life Sciences; Biomedicine; Coronaviruses; COVID-19; COVID-19 - immunology; COVID-19 - prevention & control; COVID-19 - virology; COVID-19 Vaccines - administration & dosage; COVID-19 Vaccines - immunology; Female; Humans; Immunity, Mucosal; Immunization, Secondary; Immunoglobulin A; Immunoglobulin A - immunology; Immunoglobulin G; Immunoglobulin G - blood; Immunoglobulin G - immunology; Immunology; Infections; Infectious Diseases; Lung - immunology; Lung - virology; Lymphocytes B; Lymphocytes T; Macaca mulatta; mRNA; Mucosa; Replication; Respiratory tract; SARS-CoV-2 - immunology; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - genetics; Spike Glycoprotein, Coronavirus - immunology; Vaccination - methods; Vaccines

A mucosal route of vaccination could prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication at the site of infection and limit transmission. We compared protection against heterologous XBB.1.16 challenge in nonhuman primates (NHPs) ~5 months following intramuscular boosting...