Mucosal adenovirus vaccine boosting elicits IgA and durably prevents XBB.1.16 infection in nonhuman primates - Gagne, Matthew; Flynn, Barbara J.; Andrew, Shayne F.; Marquez, Josue; Flebbe, Dillon R.; Mychalowych, Anna; Lamb, Evan; Davis-Gardner, Meredith E.; Burnett, Matthew R.; Serebryannyy, Leonid A.; Lin, Bob C.; Ziff, Zohar E.; et al. (Nature immunology, 2024)
Keywords: 631/250/2152/2153/1571; 631/250/347; 631/250/590/1867; 631/326/590/1867; 631/326/596/4130; Adenoviridae - genetics; Adenoviridae - immunology; Adenovirus Vaccines - administration & dosage; Adenovirus Vaccines - immunology; Administration, Intranasal; Animals; Antibodies, Neutralizing - blood; Antibodies, Neutralizing - immunology; Antibodies, Viral - blood; Antibodies, Viral - immunology; B-Lymphocytes - immunology; Biomedical and Life Sciences; Biomedicine; Coronaviruses; COVID-19; COVID-19 - immunology; COVID-19 - prevention & control; COVID-19 - virology; COVID-19 Vaccines - administration & dosage; COVID-19 Vaccines - immunology; Female; Humans; Immunity, Mucosal; Immunization, Secondary; Immunoglobulin A; Immunoglobulin A - immunology; Immunoglobulin G; Immunoglobulin G - blood; Immunoglobulin G - immunology; Immunology; Infections; Infectious Diseases; Lung - immunology; Lung - virology; Lymphocytes B; Lymphocytes T; Macaca mulatta; mRNA; Mucosa; Replication; Respiratory tract; SARS-CoV-2 - immunology; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - genetics; Spike Glycoprotein, Coronavirus - immunology; Vaccination - methods; Vaccines