Mucosal adenovirus vaccine boosting elicits IgA and durably prevents XBB.1.16 infection in nonhuman primates

A mucosal route of vaccination could prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication at the site of infection and limit transmission. We compared protection against heterologous XBB.1.16 challenge in nonhuman primates (NHPs) ~5 months following intramuscular boosting...

Full description

Saved in:
Bibliographic Details
Published inNature immunology Vol. 25; no. 10; pp. 1913 - 1927
Main Authors Gagne, Matthew, Flynn, Barbara J., Andrew, Shayne F., Marquez, Josue, Flebbe, Dillon R., Mychalowych, Anna, Lamb, Evan, Davis-Gardner, Meredith E., Burnett, Matthew R., Serebryannyy, Leonid A., Lin, Bob C., Ziff, Zohar E., Maule, Erin, Carroll, Robin, Naisan, Mursal, Jethmalani, Yogita, Pessaint, Laurent, Todd, John-Paul M., Doria-Rose, Nicole A., Case, James Brett, Dmitriev, Igor P., Kashentseva, Elena A., Ying, Baoling, Dodson, Alan, Kouneski, Katelyn, O’Dell, Sijy, Wali, Bushra, Ellis, Madison, Godbole, Sucheta, Laboune, Farida, Henry, Amy R., Teng, I-Ting, Wang, Danyi, Wang, Lingshu, Zhou, Qiong, Zouantchangadou, Serge, Van Ry, Alex, Lewis, Mark G., Andersen, Hanne, Kwong, Peter D., Curiel, David T., Roederer, Mario, Nason, Martha C., Foulds, Kathryn E., Suthar, Mehul S., Diamond, Michael S., Douek, Daniel C., Seder, Robert A.
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.10.2024
Nature Publishing Group
Subjects
631/250/2152/2153/1571
631/250/347
631/250/590/1867
631/326/590/1867
631/326/596/4130
Adenoviridae - genetics
Adenoviridae - immunology
Adenovirus Vaccines - administration & dosage
Adenovirus Vaccines - immunology
Administration, Intranasal
Animals
Antibodies, Neutralizing - blood
Antibodies, Neutralizing - immunology
Antibodies, Viral - blood
Antibodies, Viral - immunology
B-Lymphocytes - immunology
Biomedical and Life Sciences
Biomedicine
Coronaviruses
COVID-19
COVID-19 - immunology
COVID-19 - prevention & control
COVID-19 - virology
COVID-19 Vaccines - administration & dosage
COVID-19 Vaccines - immunology
Female
Humans
Immunity, Mucosal
Immunization, Secondary
Immunoglobulin A
Immunoglobulin A - immunology
Immunoglobulin G
Immunoglobulin G - blood
Immunoglobulin G - immunology
Immunology
Infections
Infectious Diseases
Lung - immunology
Lung - virology
Lymphocytes B
Lymphocytes T
Macaca mulatta
mRNA
Mucosa
Replication
Respiratory tract
SARS-CoV-2 - immunology
Severe acute respiratory syndrome coronavirus 2
Spike Glycoprotein, Coronavirus - genetics
Spike Glycoprotein, Coronavirus - immunology
Vaccination - methods
Vaccines
Online AccessGet full text

Cover

Abstract A mucosal route of vaccination could prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication at the site of infection and limit transmission. We compared protection against heterologous XBB.1.16 challenge in nonhuman primates (NHPs) ~5 months following intramuscular boosting with bivalent mRNA encoding WA1 and BA.5 spike proteins or mucosal boosting with a WA1–BA.5 bivalent chimpanzee adenoviral-vectored vaccine delivered by intranasal or aerosol device. NHPs boosted by either mucosal route had minimal virus replication in the nose and lungs, respectively. By contrast, protection by intramuscular mRNA was limited to the lower airways. The mucosally delivered vaccine elicited durable airway IgG and IgA responses and, unlike the intramuscular mRNA vaccine, induced spike-specific B cells in the lungs. IgG, IgA and T cell responses correlated with protection in the lungs, whereas mucosal IgA alone correlated with upper airway protection. This study highlights differential mucosal and serum correlates of protection and how mucosal vaccines can durably prevent infection against SARS-CoV-2. Seder and colleagues show that mucosal adenoviral-vectored vaccine boosting durably prevents infection in nonhuman primates of the highly transmissible, heterologous XBB.1.16 strain of SARS-CoV-2.
AbstractList A mucosal route of vaccination could prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication at the site of infection and limit transmission. We compared protection against heterologous XBB.1.16 challenge in nonhuman primates (NHPs) ~5 months following intramuscular boosting with bivalent mRNA encoding WA1 and BA.5 spike proteins or mucosal boosting with a WA1–BA.5 bivalent chimpanzee adenoviral-vectored vaccine delivered by intranasal or aerosol device. NHPs boosted by either mucosal route had minimal virus replication in the nose and lungs, respectively. By contrast, protection by intramuscular mRNA was limited to the lower airways. The mucosally delivered vaccine elicited durable airway IgG and IgA responses and, unlike the intramuscular mRNA vaccine, induced spike-specific B cells in the lungs. IgG, IgA and T cell responses correlated with protection in the lungs, whereas mucosal IgA alone correlated with upper airway protection. This study highlights differential mucosal and serum correlates of protection and how mucosal vaccines can durably prevent infection against SARS-CoV-2.Seder and colleagues show that mucosal adenoviral-vectored vaccine boosting durably prevents infection in nonhuman primates of the highly transmissible, heterologous XBB.1.16 strain of SARS-CoV-2.
A mucosal route of vaccination could prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication at the site of infection and limit transmission. We compared protection against heterologous XBB.1.16 challenge in nonhuman primates (NHPs) ~5 months following intramuscular boosting with bivalent mRNA encoding WA1 and BA.5 spike proteins or mucosal boosting with a WA1–BA.5 bivalent chimpanzee adenoviral-vectored vaccine delivered by intranasal or aerosol device. NHPs boosted by either mucosal route had minimal virus replication in the nose and lungs, respectively. By contrast, protection by intramuscular mRNA was limited to the lower airways. The mucosally delivered vaccine elicited durable airway IgG and IgA responses and, unlike the intramuscular mRNA vaccine, induced spike-specific B cells in the lungs. IgG, IgA and T cell responses correlated with protection in the lungs, whereas mucosal IgA alone correlated with upper airway protection. This study highlights differential mucosal and serum correlates of protection and how mucosal vaccines can durably prevent infection against SARS-CoV-2.
A mucosal route of vaccination could prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication at the site of infection and limit transmission. We compared protection against heterologous XBB.1.16 challenge in nonhuman primates (NHPs) ~5 months following intramuscular boosting with bivalent mRNA encoding WA1 and BA.5 spike proteins or mucosal boosting with a WA1–BA.5 bivalent chimpanzee adenoviral-vectored vaccine delivered by intranasal or aerosol device. NHPs boosted by either mucosal route had minimal virus replication in the nose and lungs, respectively. By contrast, protection by intramuscular mRNA was limited to the lower airways. The mucosally delivered vaccine elicited durable airway IgG and IgA responses and, unlike the intramuscular mRNA vaccine, induced spike-specific B cells in the lungs. IgG, IgA and T cell responses correlated with protection in the lungs, whereas mucosal IgA alone correlated with upper airway protection. This study highlights differential mucosal and serum correlates of protection and how mucosal vaccines can durably prevent infection against SARS-CoV-2. Seder and colleagues show that mucosal adenoviral-vectored vaccine boosting durably prevents infection in nonhuman primates of the highly transmissible, heterologous XBB.1.16 strain of SARS-CoV-2.
A mucosal route of vaccination could prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication at the site of infection and limit transmission. We compared protection against heterologous XBB.1.16 challenge in nonhuman primates (NHPs) ~5 months following intramuscular boosting with bivalent mRNA encoding WA1 and BA.5 spike proteins or mucosal boosting with a WA1-BA.5 bivalent chimpanzee adenoviral-vectored vaccine delivered by intranasal or aerosol device. NHPs boosted by either mucosal route had minimal virus replication in the nose and lungs, respectively. By contrast, protection by intramuscular mRNA was limited to the lower airways. The mucosally delivered vaccine elicited durable airway IgG and IgA responses and, unlike the intramuscular mRNA vaccine, induced spike-specific B cells in the lungs. IgG, IgA and T cell responses correlated with protection in the lungs, whereas mucosal IgA alone correlated with upper airway protection. This study highlights differential mucosal and serum correlates of protection and how mucosal vaccines can durably prevent infection against SARS-CoV-2.A mucosal route of vaccination could prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication at the site of infection and limit transmission. We compared protection against heterologous XBB.1.16 challenge in nonhuman primates (NHPs) ~5 months following intramuscular boosting with bivalent mRNA encoding WA1 and BA.5 spike proteins or mucosal boosting with a WA1-BA.5 bivalent chimpanzee adenoviral-vectored vaccine delivered by intranasal or aerosol device. NHPs boosted by either mucosal route had minimal virus replication in the nose and lungs, respectively. By contrast, protection by intramuscular mRNA was limited to the lower airways. The mucosally delivered vaccine elicited durable airway IgG and IgA responses and, unlike the intramuscular mRNA vaccine, induced spike-specific B cells in the lungs. IgG, IgA and T cell responses correlated with protection in the lungs, whereas mucosal IgA alone correlated with upper airway protection. This study highlights differential mucosal and serum correlates of protection and how mucosal vaccines can durably prevent infection against SARS-CoV-2.
Author Mychalowych, Anna
Douek, Daniel C.
Godbole, Sucheta
Ziff, Zohar E.
Todd, John-Paul M.
Henry, Amy R.
Suthar, Mehul S.
Diamond, Michael S.
Naisan, Mursal
Wali, Bushra
Zouantchangadou, Serge
Lin, Bob C.
Dodson, Alan
Flebbe, Dillon R.
Van Ry, Alex
Kwong, Peter D.
Roederer, Mario
Maule, Erin
Pessaint, Laurent
Seder, Robert A.
Curiel, David T.
Ellis, Madison
Teng, I-Ting
Serebryannyy, Leonid A.
Davis-Gardner, Meredith E.
Flynn, Barbara J.
Andrew, Shayne F.
O’Dell, Sijy
Foulds, Kathryn E.
Wang, Lingshu
Laboune, Farida
Gagne, Matthew
Lamb, Evan
Dmitriev, Igor P.
Jethmalani, Yogita
Wang, Danyi
Marquez, Josue
Zhou, Qiong
Andersen, Hanne
Lewis, Mark G.
Doria-Rose, Nicole A.
Kashentseva, Elena A.
Burnett, Matthew R.
Nason, Martha C.
Case, James Brett
Carroll, Robin
Ying, Baoling
Kouneski, Katelyn
Author_xml – sequence: 1
  givenname: Matthew
  surname: Gagne
  fullname: Gagne, Matthew
  organization: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
– sequence: 2
  givenname: Barbara J.
  surname: Flynn
  fullname: Flynn, Barbara J.
  organization: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
– sequence: 3
  givenname: Shayne F.
  orcidid: 0000-0001-7226-7757
  surname: Andrew
  fullname: Andrew, Shayne F.
  organization: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
– sequence: 4
  givenname: Josue
  surname: Marquez
  fullname: Marquez, Josue
  organization: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
– sequence: 5
  givenname: Dillon R.
  surname: Flebbe
  fullname: Flebbe, Dillon R.
  organization: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
– sequence: 6
  givenname: Anna
  surname: Mychalowych
  fullname: Mychalowych, Anna
  organization: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
– sequence: 7
  givenname: Evan
  surname: Lamb
  fullname: Lamb, Evan
  organization: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
– sequence: 8
  givenname: Meredith E.
  orcidid: 0000-0002-6133-3613
  surname: Davis-Gardner
  fullname: Davis-Gardner, Meredith E.
  organization: Department of Pediatrics, Center for Childhood Infections and Vaccines of Children’s Healthcare of Atlanta, Emory University School of Medicine, Emory Vaccine Center, Emory University, Emory National Primate Research Center
– sequence: 9
  givenname: Matthew R.
  surname: Burnett
  fullname: Burnett, Matthew R.
  organization: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
– sequence: 10
  givenname: Leonid A.
  surname: Serebryannyy
  fullname: Serebryannyy, Leonid A.
  organization: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
– sequence: 11
  givenname: Bob C.
  surname: Lin
  fullname: Lin, Bob C.
  organization: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
– sequence: 12
  givenname: Zohar E.
  surname: Ziff
  fullname: Ziff, Zohar E.
  organization: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
– sequence: 13
  givenname: Erin
  surname: Maule
  fullname: Maule, Erin
  organization: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
– sequence: 14
  givenname: Robin
  surname: Carroll
  fullname: Carroll, Robin
  organization: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
– sequence: 15
  givenname: Mursal
  surname: Naisan
  fullname: Naisan, Mursal
  organization: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
– sequence: 16
  givenname: Yogita
  orcidid: 0000-0003-3422-8356
  surname: Jethmalani
  fullname: Jethmalani, Yogita
  organization: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
– sequence: 17
  givenname: Laurent
  surname: Pessaint
  fullname: Pessaint, Laurent
  organization: Bioqual, Inc
– sequence: 18
  givenname: John-Paul M.
  surname: Todd
  fullname: Todd, John-Paul M.
  organization: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
– sequence: 19
  givenname: Nicole A.
  orcidid: 0000-0002-5731-3054
  surname: Doria-Rose
  fullname: Doria-Rose, Nicole A.
  organization: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
– sequence: 20
  givenname: James Brett
  orcidid: 0000-0001-7331-5511
  surname: Case
  fullname: Case, James Brett
  organization: Department of Medicine, Washington University School of Medicine
– sequence: 21
  givenname: Igor P.
  orcidid: 0000-0001-9206-1975
  surname: Dmitriev
  fullname: Dmitriev, Igor P.
  organization: Department of Radiation Oncology, Washington University School of Medicine
– sequence: 22
  givenname: Elena A.
  surname: Kashentseva
  fullname: Kashentseva, Elena A.
  organization: Department of Radiation Oncology, Washington University School of Medicine
– sequence: 23
  givenname: Baoling
  surname: Ying
  fullname: Ying, Baoling
  organization: Department of Medicine, Washington University School of Medicine
– sequence: 24
  givenname: Alan
  surname: Dodson
  fullname: Dodson, Alan
  organization: Bioqual, Inc
– sequence: 25
  givenname: Katelyn
  surname: Kouneski
  fullname: Kouneski, Katelyn
  organization: Bioqual, Inc
– sequence: 26
  givenname: Sijy
  surname: O’Dell
  fullname: O’Dell, Sijy
  organization: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
– sequence: 27
  givenname: Bushra
  surname: Wali
  fullname: Wali, Bushra
  organization: Department of Pediatrics, Center for Childhood Infections and Vaccines of Children’s Healthcare of Atlanta, Emory University School of Medicine, Emory Vaccine Center, Emory University, Emory National Primate Research Center
– sequence: 28
  givenname: Madison
  orcidid: 0000-0002-0325-5477
  surname: Ellis
  fullname: Ellis, Madison
  organization: Department of Pediatrics, Center for Childhood Infections and Vaccines of Children’s Healthcare of Atlanta, Emory University School of Medicine, Emory Vaccine Center, Emory University, Emory National Primate Research Center
– sequence: 29
  givenname: Sucheta
  surname: Godbole
  fullname: Godbole, Sucheta
  organization: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
– sequence: 30
  givenname: Farida
  surname: Laboune
  fullname: Laboune, Farida
  organization: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
– sequence: 31
  givenname: Amy R.
  surname: Henry
  fullname: Henry, Amy R.
  organization: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
– sequence: 32
  givenname: I-Ting
  surname: Teng
  fullname: Teng, I-Ting
  organization: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
– sequence: 33
  givenname: Danyi
  surname: Wang
  fullname: Wang, Danyi
  organization: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
– sequence: 34
  givenname: Lingshu
  surname: Wang
  fullname: Wang, Lingshu
  organization: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
– sequence: 35
  givenname: Qiong
  surname: Zhou
  fullname: Zhou, Qiong
  organization: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
– sequence: 36
  givenname: Serge
  surname: Zouantchangadou
  fullname: Zouantchangadou, Serge
  organization: Bioqual, Inc
– sequence: 37
  givenname: Alex
  orcidid: 0000-0002-1240-9044
  surname: Van Ry
  fullname: Van Ry, Alex
  organization: Bioqual, Inc
– sequence: 38
  givenname: Mark G.
  orcidid: 0000-0001-7852-0135
  surname: Lewis
  fullname: Lewis, Mark G.
  organization: Bioqual, Inc
– sequence: 39
  givenname: Hanne
  orcidid: 0000-0003-1103-9608
  surname: Andersen
  fullname: Andersen, Hanne
  organization: Bioqual, Inc
– sequence: 40
  givenname: Peter D.
  surname: Kwong
  fullname: Kwong, Peter D.
  organization: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
– sequence: 41
  givenname: David T.
  orcidid: 0000-0003-3802-6014
  surname: Curiel
  fullname: Curiel, David T.
  organization: Department of Radiation Oncology, Washington University School of Medicine
– sequence: 42
  givenname: Mario
  surname: Roederer
  fullname: Roederer, Mario
  organization: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
– sequence: 43
  givenname: Martha C.
  surname: Nason
  fullname: Nason, Martha C.
  organization: Biostatistics Research Branch, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
– sequence: 44
  givenname: Kathryn E.
  surname: Foulds
  fullname: Foulds, Kathryn E.
  organization: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
– sequence: 45
  givenname: Mehul S.
  orcidid: 0000-0002-2686-8380
  surname: Suthar
  fullname: Suthar, Mehul S.
  organization: Department of Pediatrics, Center for Childhood Infections and Vaccines of Children’s Healthcare of Atlanta, Emory University School of Medicine, Emory Vaccine Center, Emory University, Emory National Primate Research Center
– sequence: 46
  givenname: Michael S.
  orcidid: 0000-0002-8791-3165
  surname: Diamond
  fullname: Diamond, Michael S.
  organization: Department of Medicine, Washington University School of Medicine, Department of Pathology & Immunology, Washington University School of Medicine, Department of Molecular Microbiology, Washington University School of Medicine, The Andrew M. and Jane M. Bursky Center for Human Immunology & Immunotherapy Programs, Washington University School of Medicine, Center for Vaccines & Immunity to Microbial Pathogens, Washington University School of Medicine
– sequence: 47
  givenname: Daniel C.
  orcidid: 0000-0001-5575-8634
  surname: Douek
  fullname: Douek, Daniel C.
  email: ddouek@mail.nih.gov
  organization: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
– sequence: 48
  givenname: Robert A.
  orcidid: 0000-0003-3133-0849
  surname: Seder
  fullname: Seder, Robert A.
  email: rseder@mail.nih.gov
  organization: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
BackLink https://www.ncbi.nlm.nih.gov/pubmed/39227514$$D View this record in MEDLINE/PubMed
BookMark eNp9kUtv1TAQhS1URB_wB1ggS2y6yWUmfiRZobbiUamIDUjsLMeZ3LrKtYudXKn_Hre3LdBFVx5pvnN0POeQ7YUYiLG3CCsE0X7IElUHFdSyAuwUVuoFO0BVd1Xdod57nKHdZ4c5XwGgbLR8xfZFV9eNQnnApm-Li9lO3A4U4tanJfOtdc4H4n2MefZhzWnyzs-Zn69PuA0DH5Zk--mGXyfaUiiLX6enK1yh5j6M5GYfQ5l4iXu5bGwonN_YmfJr9nK0U6Y39-8R-_n504-zr9XF9y_nZycXlZONmqvBASqnhNI9CBiHVo-OWgm9JKS2B2qGEYXUA5JqWuu06Pq6r4eGlEKwVhyxjzvf66Xf0OBKxmQncxcj3Zhovfl_E_ylWcetQZRCi6YuDsf3Din-XijPZuOzo2mygeKSjUAApaEDWdD3T9CruKRQ_lcoBKW0RFGod_9Geszy0EQB2h3gUsw50WjKye3tKUtCPxkEc1u62ZVuSunmrnSjirR-In1wf1YkdqJc4LCm9Df2M6o_-Ky_Yg
CitedBy_id crossref_primary_10_3390_vaccines13030293
crossref_primary_10_1016_j_chom_2024_10_016
crossref_primary_10_1038_s41590_024_01950_6
crossref_primary_10_1172_jci_insight_185953
crossref_primary_10_1016_j_ymthe_2024_10_016
Cites_doi 10.1016/j.cell.2021.05.040
10.1002/cyto.a.21015
10.1056/NEJMc2115597
10.1016/j.omtn.2019.01.013
10.1056/NEJMoa2024671
10.1056/NEJMoa2201570
10.1073/pnas.1015536108
10.1016/j.jcf.2015.04.003
10.1073/pnas.1707304114
10.1038/s41467-022-33985-4
10.1128/mBio.02527-21
10.1073/pnas.1115369109
10.1084/jem.194.11.1597
10.1126/scitranslmed.abi4547
10.1016/j.cell.2021.03.029
10.1038/s41467-023-35815-7
10.4049/jimmunol.1400676
10.4161/hv.29108
10.1016/j.ebiom.2022.104402
10.1016/j.vaccine.2020.09.018
10.1126/scitranslmed.abn1413
10.1038/s41591-022-02051-3
10.1016/j.cell.2020.09.037
10.1038/s41586-023-06025-4
10.1001/jama.2021.4388
10.1038/s41541-023-00717-8
10.1126/science.abq1841
10.1126/sciimmunol.add4853
10.1016/j.cell.2020.08.026
10.1016/j.immuni.2022.08.017
10.1016/j.cell.2022.03.038
10.1038/s41590-018-0260-6
10.1016/j.cell.2022.11.006
10.1016/j.celrep.2021.109452
10.1038/s41591-022-01753-y
10.1126/science.abj4176
10.1093/cid/ciac571
10.1056/NEJMoa2114228
10.1038/s41586-023-05715-3
10.1126/scitranslmed.ade0424
10.1128/IAI.69.4.2328-2338.2001
10.1038/s41591-022-02092-8
10.1002/cyto.a.23670
10.1016/j.ebiom.2022.104298
10.1016/j.cell.2022.03.024
10.1126/science.add2897
10.1038/s41586-023-06951-3
10.1126/science.abm3425
10.1126/sciimmunol.abq7647
10.1056/NEJMc2108829
10.3389/fimmu.2023.1146841
10.1016/j.chom.2021.11.006
10.1038/s41541-019-0113-9
10.1038/s41467-023-37715-2
10.1056/NEJMoa2109072
10.3389/fmicb.2017.00900
10.1056/NEJMc2209651
10.1016/j.xcrm.2021.100230
10.1038/s41541-023-00662-6
10.1126/science.abb2507
10.1126/sciimmunol.adg7015
10.1016/0042-6822(68)90121-9
10.1038/s41586-020-2324-7
10.1007/s12250-020-00230-5
10.1126/science.abo2523
10.1038/s41541-023-00654-6
10.1093/cid/ciad505
10.1126/science.abl8912
10.1128/JVI.00979-13
10.1126/scitranslmed.abj6824
10.1038/s41590-024-01743-x
10.1016/j.cell.2022.01.018
10.1038/s41467-023-41049-4
10.1002/cpim.116
10.1056/NEJMc2115596
10.1016/j.cell.2021.02.026
10.1126/sciadv.adh1655
10.1016/j.cell.2021.12.002
10.1126/science.abj9853
10.1056/NEJMc2107799
10.1126/science.1243283
10.1038/s41423-022-00838-5
10.1126/science.abj0299
10.1016/j.cell.2020.09.038
10.1371/journal.pntd.0006862
10.1056/NEJMc2302462
10.1126/science.abd0826
10.1016/S2666-5247(23)00102-7
10.1016/S1473-3099(21)00396-0
10.1038/s41590-021-01021-0
10.1084/jem.20201993
10.1016/j.cell.2022.01.015
10.1038/s41564-023-01359-1
10.1056/NEJMc2214293
10.1016/j.celrep.2021.109400
10.1371/journal.pone.0268767
10.1016/j.vaccine.2011.09.109
10.1016/j.chom.2021.03.009
10.1056/NEJMoa2115481
10.1016/j.cell.2021.03.013
ContentType Journal Article
Copyright This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2024
2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2024 2024
Copyright_xml – notice: This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2024
– notice: 2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
– notice: This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2024 2024
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7QP
7QR
7T5
7TK
7TM
7U9
8FD
FR3
H94
K9.
M7N
P64
RC3
7X8
5PM
DOI 10.1038/s41590-024-01951-5
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Immunology Abstracts
Neurosciences Abstracts
Nucleic Acids Abstracts
Virology and AIDS Abstracts
Technology Research Database
Engineering Research Database
AIDS and Cancer Research Abstracts
ProQuest Health & Medical Complete (Alumni)
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biotechnology and BioEngineering Abstracts
Genetics Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Virology and AIDS Abstracts
Technology Research Database
Nucleic Acids Abstracts
ProQuest Health & Medical Complete (Alumni)
Neurosciences Abstracts
Biotechnology and BioEngineering Abstracts
Genetics Abstracts
Algology Mycology and Protozoology Abstracts (Microbiology C)
AIDS and Cancer Research Abstracts
Chemoreception Abstracts
Immunology Abstracts
Engineering Research Database
Calcium & Calcified Tissue Abstracts
MEDLINE - Academic
DatabaseTitleList Virology and AIDS Abstracts
CrossRef


MEDLINE
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Biology
EISSN 1529-2916
EndPage 1927
ExternalDocumentID PMC11436372
39227514
10_1038_s41590_024_01951_5
Genre Journal Article
GrantInformation_xml – fundername: Emory Executive Vice President for Health Affairs Synergy Fund award; COVID-Catalyst-I3 Funds from the Woodruff Health Sciences Center and Emory School of Medicine; the Pediatric Research Alliance Center for Childhood Infections and Vaccines and Children’s Healthcare of Atlanta; and Woodruff Health Sciences Center 2020 COVID-19 CURE Award
– fundername: U.S. Department of Health & Human Services | National Institutes of Health (NIH)
  grantid: R01 CA211096; R01 AI157155
  funderid: https://doi.org/10.13039/100000002
– fundername: U.S. Department of Health & Human Services | NIH | NIH Office of the Director (OD)
  grantid: P51 OD011132
  funderid: https://doi.org/10.13039/100000052
– fundername: Division of Intramural Research, National Institute of Allergy and Infectious Diseases (Division of Intramural Research of the NIAID)
  funderid: https://doi.org/10.13039/100006492
– fundername: U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID)
  grantid: 75N93021C00017; HHSN272201400008C; 75N93021C00014; 75N93019C00051
  funderid: https://doi.org/10.13039/100000060
– fundername: NIAID NIH HHS
  grantid: HHSN272201400008C
– fundername: NIAID NIH HHS
  grantid: 75N93021C00017
– fundername: NIAID NIH HHS
  grantid: 75N93021C00014
– fundername: NIAID NIH HHS
  grantid: R01 AI157155
– fundername: NCI NIH HHS
  grantid: R01 CA211096
– fundername: NIAID NIH HHS
  grantid: 75N93019C00051
– fundername: NIH HHS
  grantid: P51 OD011132
– fundername: ODCDC CDC HHS
  grantid: P51 OD011132
GroupedDBID ---
.55
0R~
123
29M
2FS
36B
39C
3V.
4.4
53G
5BI
5RE
70F
7X7
88E
8AO
8C1
8FE
8FH
8FI
8FJ
8R4
8R5
AAEEF
AAHBH
AARCD
AAYZH
AAZLF
ABAWZ
ABDBF
ABJNI
ABLJU
ABNNU
ABOCM
ABUWG
ACBWK
ACGFS
ACIWK
ACPRK
ACRPL
ACUHS
ADBBV
ADNMO
AENEX
AEUYN
AFBBN
AFKRA
AFRAH
AFSHS
AGAYW
AGGDT
AGHTU
AHBCP
AHMBA
AHOSX
AHSBF
AIBTJ
AIYXT
ALFFA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
ARMCB
ASPBG
AVWKF
AXYYD
AZFZN
BBNVY
BENPR
BHPHI
BKKNO
BPHCQ
BVXVI
C6C
CCPQU
CS3
DB5
DU5
EAD
EAP
EAS
EBS
EE.
EJD
EMB
EMK
EMOBN
ESX
EXGXG
F5P
FEDTE
FQGFK
FSGXE
FYUFA
HCIFZ
HMCUK
HVGLF
HZ~
IAO
IHR
INH
INR
ISR
ITC
L-9
LK8
M1P
M7P
N9A
NNMJJ
O9-
ODYON
P2P
PQQKQ
PROAC
PSQYO
Q2X
RNT
RNTTT
SHXYY
SIXXV
SNYQT
SOJ
SV3
TAOOD
TBHMF
TDRGL
TSG
TUS
UKHRP
WH7
X7M
Y6R
ZXP
AAYXX
ABFSG
ACSTC
AEZWR
AFANA
AFHIU
AHWEU
AIXLP
ALPWD
ATHPR
CITATION
NFIDA
CGR
CUY
CVF
ECM
EIF
NPM
7QP
7QR
7T5
7TK
7TM
7U9
8FD
FR3
H94
K9.
M7N
P64
RC3
7X8
5PM
PHGZM
PHGZT
PJZUB
PPXIY
PQGLB
ID FETCH-LOGICAL-c475t-dc015c5356b030fd86fce840b4e1e8b0e7df1346d1e578ac639b2b2d7e5510aa3
IEDL.DBID C6C
ISSN 1529-2908
1529-2916
IngestDate Thu Aug 21 18:31:21 EDT 2025
Sun Aug 24 03:30:26 EDT 2025
Sat Aug 23 12:50:20 EDT 2025
Sat Jan 18 02:17:20 EST 2025
Thu Apr 24 23:02:03 EDT 2025
Tue Jul 01 01:02:36 EDT 2025
Fri Feb 21 02:39:01 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 10
Language English
License 2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c475t-dc015c5356b030fd86fce840b4e1e8b0e7df1346d1e578ac639b2b2d7e5510aa3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0002-6133-3613
0000-0001-7226-7757
0000-0003-1103-9608
0000-0001-5575-8634
0000-0001-7331-5511
0000-0003-3422-8356
0000-0002-8791-3165
0000-0003-3802-6014
0000-0001-9206-1975
0000-0003-3133-0849
0000-0002-1240-9044
0000-0001-7852-0135
0000-0002-0325-5477
0000-0002-2686-8380
0000-0002-5731-3054
OpenAccessLink https://www.nature.com/articles/s41590-024-01951-5
PMID 39227514
PQID 3110556413
PQPubID 45782
PageCount 15
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_11436372
proquest_miscellaneous_3100560904
proquest_journals_3110556413
pubmed_primary_39227514
crossref_citationtrail_10_1038_s41590_024_01951_5
crossref_primary_10_1038_s41590_024_01951_5
springer_journals_10_1038_s41590_024_01951_5
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2024-10-01
PublicationDateYYYYMMDD 2024-10-01
PublicationDate_xml – month: 10
  year: 2024
  text: 2024-10-01
  day: 01
PublicationDecade 2020
PublicationPlace New York
PublicationPlace_xml – name: New York
– name: United States
PublicationTitle Nature immunology
PublicationTitleAbbrev Nat Immunol
PublicationTitleAlternate Nat Immunol
PublicationYear 2024
Publisher Nature Publishing Group US
Nature Publishing Group
Publisher_xml – name: Nature Publishing Group US
– name: Nature Publishing Group
References Munster (CR40) 2020; 585
Bricker (CR31) 2021; 36
Tseng (CR43) 2022; 28
Havervall (CR19) 2022; 387
Wrapp (CR87) 2020; 367
Katzelnick (CR99) 2018; 12
Chang (CR81) 2022; 14
Madhavan (CR25) 2022; 85
Corbett (CR34) 2021; 22
Edara, Hudson, Xie, Ahmed, Suthar (CR95) 2021; 325
Roederer, Nozzi, Nason (CR101) 2011; 79
Zohar (CR68) 2022; 30
Schafer (CR48) 2021; 218
Hassan (CR30) 2021; 2
Goldberg (CR7) 2021; 385
Maizel, White, Scharff (CR90) 1968; 36
Li (CR42) 2022; 13
Choi (CR78) 2022; 19
Solforosi (CR39) 2023; 14
Vanderheiden (CR98) 2020; 131
Rydyznski Moderbacher (CR65) 2020; 183
Edara (CR93) 2021; 29
Onodera (CR53) 2012; 109
Knisely (CR18) 2023; 8
Schiepers (CR55) 2023; 615
Gilbert (CR66) 2022; 375
Roltgen (CR16) 2022; 185
Teng (CR100) 2022; 17
Le Nouen (CR23) 2022; 185
Garcia-Beltran (CR13) 2021; 184
Block, Yi, Sheldon, Dubovsky, Falloon (CR80) 2011; 29
Rossler (CR12) 2023; 14
Hawks (CR84) 2021; 12
Ponce-de-Leon (CR24) 2023; 8
Wu (CR26) 2021; 21
Suryadevara (CR46) 2021; 184
Liew (CR57) 2023; 87
Ying (CR32) 2024; 25
Hassan (CR33) 2021; 36
Custers (CR86) 2021; 39
Singh (CR28) 2023; 8
Tseng (CR2) 2023; 14
Zuo, Marcotte, Hammarstrom, Pan-Hammarstrom (CR20) 2022; 387
Darrah (CR74) 2019; 4
Pallesen (CR83) 2017; 114
Tang (CR67) 2022; 7
Pegu (CR49) 2021; 373
Francica (CR58) 2021; 13
Wherry, Barouch (CR64) 2022; 377
Gould (CR70) 2017; 8
Reynolds (CR15) 2022; 377
Bar-On (CR44) 2022; 386
Hartwell (CR85) 2022; 14
Mao (CR21) 2022; 378
Tarke (CR62) 2022; 185
Griggs (CR6) 2023; 78
Barouch (CR50) 2021; 385
Riou (CR77) 2022; 14
Lin (CR3) 2023; 388
Baden (CR8) 2021; 385
Donaldson, Kao, Foulds (CR102) 2019; 95
Song (CR92) 2010; 107
Scheaffer (CR54) 2023; 29
Edara (CR97) 2021; 385
Mateus (CR61) 2021; 374
Bowe, Xie, Al-Aly (CR4) 2022; 28
He (CR11) 2021; 184
Corbett (CR10) 2021; 373
Wellford (CR73) 2022; 55
Corbett (CR37) 2021; 374
Lei, Yang, Hu, Sun (CR94) 2021; 36
Bergwerk (CR9) 2021; 385
Malahe (CR5) 2023; 76
Alsoussi (CR17) 2023; 617
Sawicki, Chou, Raimundo, Trzaskoma, Konstan (CR79) 2015; 14
Darrah (CR75) 2014; 193
Corbett (CR91) 2020; 383
Hokey (CR76) 2014; 10
Egri (CR63) 2023; 14
Hsieh (CR89) 2020; 369
Carabelli (CR14) 2023; 21
Hassan (CR29) 2020; 183
Routhu (CR41) 2023; 8
Shimoda (CR71) 2001; 194
Allie (CR52) 2019; 20
Liu (CR60) 2022; 7
Baldeon Vaca (CR22) 2023; 9
Davis-Gardner (CR96) 2022; 388
McLellan (CR82) 2013; 342
Collier (CR51) 2021; 385
Bladh (CR56) 2023; 4
Mackin (CR45) 2023; 8
Seibert (CR69) 2013; 87
Hodge (CR72) 2001; 69
Gagne (CR36) 2022; 185
Piccoli (CR59) 2020; 183
Chandrashekar (CR38) 2022; 185
Winkler (CR47) 2021; 184
McMahan (CR27) 2023; 626
Hassett (CR88) 2019; 15
Gagne (CR35) 2022; 185
Andrews (CR1) 2022; 386
KS Corbett (1951_CR10) 2021; 373
X He (1951_CR11) 2021; 184
K Song (1951_CR92) 2010; 107
A Schafer (1951_CR48) 2021; 218
SM Scheaffer (1951_CR54) 2023; 29
C Lei (1951_CR94) 2021; 36
HF Tseng (1951_CR43) 2022; 28
T Zohar (1951_CR68) 2022; 30
A Tarke (1951_CR62) 2022; 185
GS Sawicki (1951_CR79) 2015; 14
SA Hawks (1951_CR84) 2021; 12
J Tang (1951_CR67) 2022; 7
CJ Reynolds (1951_CR15) 2022; 377
PA Darrah (1951_CR74) 2019; 4
M Gagne (1951_CR36) 2022; 185
IT Teng (1951_CR100) 2022; 17
WF Garcia-Beltran (1951_CR13) 2021; 184
SRK Malahe (1951_CR5) 2023; 76
L Solforosi (1951_CR39) 2023; 14
SL Block (1951_CR80) 2011; 29
BL Hartwell (1951_CR85) 2022; 14
AO Hassan (1951_CR30) 2021; 2
LM Hodge (1951_CR72) 2001; 69
AO Hassan (1951_CR33) 2021; 36
ES Winkler (1951_CR47) 2021; 184
LR Baden (1951_CR8) 2021; 385
MM Donaldson (1951_CR102) 2019; 95
EP Griggs (1951_CR6) 2023; 78
JM Knisely (1951_CR18) 2023; 8
S Ponce-de-Leon (1951_CR24) 2023; 8
VMW Gould (1951_CR70) 2017; 8
DA Hokey (1951_CR76) 2014; 10
M Bergwerk (1951_CR9) 2021; 385
VV Edara (1951_CR97) 2021; 385
A Vanderheiden (1951_CR98) 2020; 131
T Mao (1951_CR21) 2022; 378
C Rydyznski Moderbacher (1951_CR65) 2020; 183
LA Chang (1951_CR81) 2022; 14
CW Seibert (1951_CR69) 2013; 87
KJ Hassett (1951_CR88) 2019; 15
M Madhavan (1951_CR25) 2022; 85
CL Hsieh (1951_CR89) 2020; 369
VJ Munster (1951_CR40) 2020; 585
B Ying (1951_CR32) 2024; 25
G Baldeon Vaca (1951_CR22) 2023; 9
F Zuo (1951_CR20) 2022; 387
KS Corbett (1951_CR91) 2020; 383
YM Bar-On (1951_CR44) 2022; 386
JR Francica (1951_CR58) 2021; 13
PA Darrah (1951_CR75) 2014; 193
S Havervall (1951_CR19) 2022; 387
DH Barouch (1951_CR50) 2021; 385
J Pallesen (1951_CR83) 2017; 114
SJ Choi (1951_CR78) 2022; 19
JS McLellan (1951_CR82) 2013; 342
WB Alsoussi (1951_CR17) 2023; 617
SA Wellford (1951_CR73) 2022; 55
A Rossler (1951_CR12) 2023; 14
TL Bricker (1951_CR31) 2021; 36
T Onodera (1951_CR53) 2012; 109
J Custers (1951_CR86) 2021; 39
PB Gilbert (1951_CR66) 2022; 375
SR Allie (1951_CR52) 2019; 20
M Gagne (1951_CR35) 2022; 185
ME Davis-Gardner (1951_CR96) 2022; 388
SR Mackin (1951_CR45) 2023; 8
C Le Nouen (1951_CR23) 2022; 185
VV Edara (1951_CR95) 2021; 325
D Li (1951_CR42) 2022; 13
N Suryadevara (1951_CR46) 2021; 184
AO Hassan (1951_CR29) 2020; 183
S Wu (1951_CR26) 2021; 21
A Pegu (1951_CR49) 2021; 373
NK Routhu (1951_CR41) 2023; 8
VV Edara (1951_CR93) 2021; 29
Y Goldberg (1951_CR7) 2021; 385
L Piccoli (1951_CR59) 2020; 183
D Wrapp (1951_CR87) 2020; 367
JV Maizel Jr. (1951_CR90) 1968; 36
DY Lin (1951_CR3) 2023; 388
J Liu (1951_CR60) 2022; 7
A Chandrashekar (1951_CR38) 2022; 185
KS Corbett (1951_CR37) 2021; 374
O Bladh (1951_CR56) 2023; 4
HF Tseng (1951_CR2) 2023; 14
AY Collier (1951_CR51) 2021; 385
LC Katzelnick (1951_CR99) 2018; 12
M Shimoda (1951_CR71) 2001; 194
J Mateus (1951_CR61) 2021; 374
AM Carabelli (1951_CR14) 2023; 21
KS Corbett (1951_CR34) 2021; 22
F Liew (1951_CR57) 2023; 87
K McMahan (1951_CR27) 2023; 626
M Roederer (1951_CR101) 2011; 79
A Schiepers (1951_CR55) 2023; 615
N Egri (1951_CR63) 2023; 14
K Roltgen (1951_CR16) 2022; 185
C Riou (1951_CR77) 2022; 14
B Bowe (1951_CR4) 2022; 28
EJ Wherry (1951_CR64) 2022; 377
C Singh (1951_CR28) 2023; 8
N Andrews (1951_CR1) 2022; 386
37986823 - bioRxiv. 2023 Nov 08:2023.11.06.565765. doi: 10.1101/2023.11.06.565765
References_xml – volume: 184
  start-page: 3467
  year: 2021
  end-page: 3473
  ident: CR11
  article-title: Low-dose Ad26.COV2.S protection against SARS-CoV-2 challenge in rhesus macaques
  publication-title: Cell
  doi: 10.1016/j.cell.2021.05.040
– volume: 387
  start-page: e55
  year: 2022
  ident: CR20
  article-title: Mucosal IgA against SARS-CoV-2 omicron infection
  publication-title: N. Engl. J. Med.
– volume: 79
  start-page: 167
  year: 2011
  end-page: 174
  ident: CR101
  article-title: SPICE: exploration and analysis of post-cytometric complex multivariate datasets
  publication-title: Cytometry A
  doi: 10.1002/cyto.a.21015
– volume: 385
  start-page: 2485
  year: 2021
  end-page: 2487
  ident: CR8
  article-title: Phase 3 trial of mRNA-1273 during the Delta-variant surge
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMc2115597
– volume: 15
  start-page: 1
  year: 2019
  end-page: 11
  ident: CR88
  article-title: Optimization of lipid nanoparticles for intramuscular administration of mRNA vaccines
  publication-title: Mol. Ther. Nucleic Acids
  doi: 10.1016/j.omtn.2019.01.013
– volume: 383
  start-page: 1544
  year: 2020
  end-page: 1555
  ident: CR91
  article-title: Evaluation of the mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa2024671
– volume: 386
  start-page: 1712
  year: 2022
  end-page: 1720
  ident: CR44
  article-title: Protection by a fourth dose of BNT162b2 against Omicron in Israel
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa2201570
– volume: 107
  start-page: 22213
  year: 2010
  end-page: 22218
  ident: CR92
  article-title: Genetic immunization in the lung induces potent local and systemic immune responses
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1015536108
– volume: 14
  start-page: 777
  year: 2015
  end-page: 783
  ident: CR79
  article-title: Randomized trial of efficacy and safety of dornase alfa delivered by eRapid nebulizer in cystic fibrosis patients
  publication-title: J. Cyst. Fibros.
  doi: 10.1016/j.jcf.2015.04.003
– volume: 114
  start-page: E7348
  year: 2017
  end-page: E7357
  ident: CR83
  article-title: Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1707304114
– volume: 13
  year: 2022
  ident: CR42
  article-title: Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-022-33985-4
– volume: 12
  year: 2021
  ident: CR84
  article-title: Infectious SARS-CoV-2 is emitted in aerosol particles
  publication-title: mBio
  doi: 10.1128/mBio.02527-21
– volume: 109
  start-page: 2485
  year: 2012
  end-page: 2490
  ident: CR53
  article-title: Memory B cells in the lung participate in protective humoral immune responses to pulmonary influenza virus reinfection
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1115369109
– volume: 194
  start-page: 1597
  year: 2001
  end-page: 1607
  ident: CR71
  article-title: Isotype-specific selection of high affinity memory B cells in nasal-associated lymphoid tissue
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.194.11.1597
– volume: 13
  start-page: eabi4547
  year: 2021
  ident: CR58
  article-title: Protective antibodies elicited by SARS-CoV-2 spike protein vaccination are boosted in the lung after challenge in nonhuman primates
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.abi4547
– volume: 184
  start-page: 2316
  year: 2021
  end-page: 2331
  ident: CR46
  article-title: Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein
  publication-title: Cell
  doi: 10.1016/j.cell.2021.03.029
– volume: 14
  year: 2023
  ident: CR2
  article-title: Effectiveness of mRNA-1273 vaccination against SARS-CoV-2 omicron subvariants BA.1, BA.2, BA.2.12.1, BA.4, and BA.5
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-023-35815-7
– volume: 193
  start-page: 1799
  year: 2014
  end-page: 1811
  ident: CR75
  article-title: Aerosol vaccination with AERAS-402 elicits robust cellular immune responses in the lungs of rhesus macaques but fails to protect against high-dose challenge
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1400676
– volume: 10
  start-page: 2199
  year: 2014
  end-page: 2210
  ident: CR76
  article-title: A nonhuman primate toxicology and immunogenicity study evaluating aerosol delivery of AERAS-402/Ad35 vaccine: evidence for transient T cell responses in peripheral blood and robust sustained responses in the lungs
  publication-title: Hum. Vaccin. Immunother.
  doi: 10.4161/hv.29108
– volume: 87
  start-page: 104402
  year: 2023
  ident: CR57
  article-title: SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination
  publication-title: EBioMedicine
  doi: 10.1016/j.ebiom.2022.104402
– volume: 39
  start-page: 3081
  year: 2021
  end-page: 3101
  ident: CR86
  article-title: Vaccines based on replication incompetent Ad26 viral vectors: standardized template with key considerations for a risk/benefit assessment
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2020.09.018
– volume: 14
  year: 2022
  ident: CR85
  article-title: Intranasal vaccination with lipid-conjugated immunogens promotes antigen transmucosal uptake to drive mucosal and systemic immunity
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.abn1413
– volume: 28
  start-page: 2398
  year: 2022
  end-page: 2405
  ident: CR4
  article-title: Acute and postacute sequelae associated with SARS-CoV-2 reinfection
  publication-title: Nat. Med.
  doi: 10.1038/s41591-022-02051-3
– volume: 183
  start-page: 1024
  year: 2020
  end-page: 1042
  ident: CR59
  article-title: Mapping neutralizing and immunodominant sites on the SARS-CoV-2 spike receptor-binding domain by structure-guided high-resolution serology
  publication-title: Cell
  doi: 10.1016/j.cell.2020.09.037
– volume: 617
  start-page: 592
  year: 2023
  end-page: 598
  ident: CR17
  article-title: SARS-CoV-2 Omicron boosting induces de novo B cell response in humans
  publication-title: Nature
  doi: 10.1038/s41586-023-06025-4
– volume: 325
  start-page: 1896
  year: 2021
  end-page: 1898
  ident: CR95
  article-title: Neutralizing antibodies against SARS-CoV-2 variants after infection and vaccination
  publication-title: JAMA
  doi: 10.1001/jama.2021.4388
– volume: 8
  year: 2023
  ident: CR28
  article-title: Phase III pivotal comparative clinical trial of intranasal (iNCOVACC) and intramuscular COVID 19 vaccine (Covaxin)
  publication-title: NPJ Vaccines
  doi: 10.1038/s41541-023-00717-8
– volume: 377
  start-page: eabq1841
  year: 2022
  ident: CR15
  article-title: Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure
  publication-title: Science
  doi: 10.1126/science.abq1841
– volume: 7
  start-page: eadd4853
  year: 2022
  ident: CR67
  article-title: Respiratory mucosal immunity against SARS-CoV-2 after mRNA vaccination
  publication-title: Sci. Immunol.
  doi: 10.1126/sciimmunol.add4853
– volume: 183
  start-page: 169
  year: 2020
  end-page: 184
  ident: CR29
  article-title: A single-dose intranasal ChAd vaccine protects upper and lower respiratory tracts against SARS-CoV-2
  publication-title: Cell
  doi: 10.1016/j.cell.2020.08.026
– volume: 55
  start-page: 2118
  year: 2022
  end-page: 2134
  ident: CR73
  article-title: Mucosal plasma cells are required to protect the upper airway and brain from infection
  publication-title: Immunity
  doi: 10.1016/j.immuni.2022.08.017
– volume: 185
  start-page: 1556
  year: 2022
  end-page: 1571
  ident: CR36
  article-title: mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits similar B cell expansion, neutralizing responses, and protection from Omicron
  publication-title: Cell
  doi: 10.1016/j.cell.2022.03.038
– volume: 20
  start-page: 97
  year: 2019
  end-page: 108
  ident: CR52
  article-title: The establishment of resident memory B cells in the lung requires local antigen encounter
  publication-title: Nat. Immunol.
  doi: 10.1038/s41590-018-0260-6
– volume: 185
  start-page: 4811
  year: 2022
  end-page: 4825
  ident: CR23
  article-title: Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine is protective in monkeys
  publication-title: Cell
  doi: 10.1016/j.cell.2022.11.006
– volume: 36
  year: 2021
  ident: CR33
  article-title: An intranasal vaccine durably protects against SARS-CoV-2 variants in mice
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2021.109452
– volume: 28
  start-page: 1063
  year: 2022
  end-page: 1071
  ident: CR43
  article-title: Effectiveness of mRNA-1273 against SARS-CoV-2 Omicron and Delta variants
  publication-title: Nat. Med.
  doi: 10.1038/s41591-022-01753-y
– volume: 373
  start-page: 1372
  year: 2021
  end-page: 1377
  ident: CR49
  article-title: Durability of mRNA-1273 vaccine-induced antibodies against SARS-CoV-2 variants
  publication-title: Science
  doi: 10.1126/science.abj4176
– volume: 76
  start-page: e172
  year: 2023
  end-page: e178
  ident: CR5
  article-title: Clinical characteristics and outcomes of immunocompromised patients with coronavirus disease 2019 caused by the Omicron variant: a prospective, observational study
  publication-title: Clin. Infect. Dis.
  doi: 10.1093/cid/ciac571
– volume: 385
  year: 2021
  ident: CR7
  article-title: Waning immunity after the BNT162b2 vaccine in Israel
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa2114228
– volume: 615
  start-page: 482
  year: 2023
  end-page: 489
  ident: CR55
  article-title: Molecular fate-mapping of serum antibody responses to repeat immunization
  publication-title: Nature
  doi: 10.1038/s41586-023-05715-3
– volume: 14
  year: 2022
  ident: CR81
  article-title: A prefusion-stabilized RSV F subunit vaccine elicits B cell responses with greater breadth and potency than a postfusion F vaccine
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.ade0424
– volume: 69
  start-page: 2328
  year: 2001
  end-page: 2338
  ident: CR72
  article-title: Immunoglobulin A (IgA) responses and IgE-associated inflammation along the respiratory tract after mucosal but not systemic immunization
  publication-title: Infect. Immun.
  doi: 10.1128/IAI.69.4.2328-2338.2001
– volume: 29
  start-page: 247
  year: 2023
  end-page: 257
  ident: CR54
  article-title: Bivalent SARS-CoV-2 mRNA vaccines increase breadth of neutralization and protect against the BA.5 Omicron variant in mice
  publication-title: Nat. Med.
  doi: 10.1038/s41591-022-02092-8
– volume: 95
  start-page: 261
  year: 2019
  end-page: 263
  ident: CR102
  article-title: OMIP-052: an 18-color panel for measuring T 1, T 2, T 17, and T responses in rhesus macaques
  publication-title: Cytometry A
  doi: 10.1002/cyto.a.23670
– volume: 85
  year: 2022
  ident: CR25
  article-title: Tolerability and immunogenicity of an intranasally-administered adenovirus-vectored COVID-19 vaccine: an open-label partially-randomised ascending dose phase I trial
  publication-title: EBioMedicine
  doi: 10.1016/j.ebiom.2022.104298
– volume: 185
  start-page: 1549
  year: 2022
  end-page: 1555
  ident: CR38
  article-title: Vaccine protection against the SARS-CoV-2 Omicron variant in macaques
  publication-title: Cell
  doi: 10.1016/j.cell.2022.03.024
– volume: 377
  start-page: 821
  year: 2022
  end-page: 822
  ident: CR64
  article-title: T cell immunity to COVID-19 vaccines
  publication-title: Science
  doi: 10.1126/science.add2897
– volume: 626
  start-page: 385
  year: 2023
  end-page: 391
  ident: CR27
  article-title: Mucosal boosting enhances vaccine protection against SARS-CoV-2 in macaques
  publication-title: Nature
  doi: 10.1038/s41586-023-06951-3
– volume: 375
  start-page: 43
  year: 2022
  end-page: 50
  ident: CR66
  article-title: Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trial
  publication-title: Science
  doi: 10.1126/science.abm3425
– volume: 7
  year: 2022
  ident: CR60
  article-title: CD8 T cells contribute to vaccine protection against SARS-CoV-2 in macaques
  publication-title: Sci. Immunol.
  doi: 10.1126/sciimmunol.abq7647
– volume: 385
  start-page: 951
  year: 2021
  end-page: 953
  ident: CR50
  article-title: Durable humoral and cellular immune responses 8 months after Ad26.COV2.S vaccination
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMc2108829
– volume: 14
  year: 2023
  ident: CR63
  article-title: Cellular and humoral responses after second and third SARS-CoV-2 vaccinations in patients with autoimmune diseases treated with rituximab: specific T cell immunity remains longer and plays a protective role against SARS-CoV-2 reinfections
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2023.1146841
– volume: 30
  start-page: 41
  year: 2022
  end-page: 52
  ident: CR68
  article-title: Upper and lower respiratory tract correlates of protection against respiratory syncytial virus following vaccination of nonhuman primates
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2021.11.006
– volume: 4
  year: 2019
  ident: CR74
  article-title: Boosting BCG with proteins or rAd5 does not enhance protection against tuberculosis in rhesus macaques
  publication-title: NPJ Vaccines
  doi: 10.1038/s41541-019-0113-9
– volume: 14
  year: 2023
  ident: CR39
  article-title: Booster with Ad26.COV2.S or Omicron-adapted vaccine enhanced immunity and efficacy against SARS-CoV-2 Omicron in macaques
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-023-37715-2
– volume: 385
  start-page: 1474
  year: 2021
  end-page: 1484
  ident: CR9
  article-title: COVID-19 breakthrough infections in vaccinated health care workers
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa2109072
– volume: 8
  start-page: 900
  year: 2017
  ident: CR70
  article-title: Nasal IgA provides protection against human influenza challenge in volunteers with low serum influenza antibody titre
  publication-title: Front. Microbiol.
  doi: 10.3389/fmicb.2017.00900
– volume: 387
  start-page: 1333
  year: 2022
  end-page: 1336
  ident: CR19
  article-title: Anti-spike mucosal IgA protection against SARS-CoV-2 Omicron infection
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMc2209651
– volume: 2
  year: 2021
  ident: CR30
  article-title: A single intranasal dose of chimpanzee adenovirus-vectored vaccine protects against SARS-CoV-2 infection in rhesus macaques
  publication-title: Cell Rep. Med.
  doi: 10.1016/j.xcrm.2021.100230
– volume: 8
  year: 2023
  ident: CR24
  article-title: Interim safety and immunogenicity results from an NDV-based COVID-19 vaccine phase I trial in Mexico
  publication-title: NPJ Vaccines
  doi: 10.1038/s41541-023-00662-6
– volume: 367
  start-page: 1260
  year: 2020
  end-page: 1263
  ident: CR87
  article-title: Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
  publication-title: Science
  doi: 10.1126/science.abb2507
– volume: 8
  year: 2023
  ident: CR41
  article-title: Efficacy of mRNA-1273 and Novavax ancestral or BA.1 spike booster vaccines against SARS-CoV-2 BA.5 infection in non-human primates
  publication-title: Sci. Immunol.
  doi: 10.1126/sciimmunol.adg7015
– volume: 36
  start-page: 115
  year: 1968
  end-page: 125
  ident: CR90
  article-title: The polypeptides of adenovirus. I. Evidence for multiple protein components in the virion and a comparison of types 2, 7A, and 12
  publication-title: Virology
  doi: 10.1016/0042-6822(68)90121-9
– volume: 585
  start-page: 268
  year: 2020
  end-page: 272
  ident: CR40
  article-title: Respiratory disease in rhesus macaques inoculated with SARS-CoV-2
  publication-title: Nature
  doi: 10.1038/s41586-020-2324-7
– volume: 36
  start-page: 141
  year: 2021
  end-page: 144
  ident: CR94
  article-title: On the calculation of TCID for quantitation of virus infectivity
  publication-title: Virol. Sin.
  doi: 10.1007/s12250-020-00230-5
– volume: 378
  year: 2022
  ident: CR21
  article-title: Unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses
  publication-title: Science
  doi: 10.1126/science.abo2523
– volume: 8
  year: 2023
  ident: CR18
  article-title: Mucosal vaccines for SARS-CoV-2: scientific gaps and opportunities-workshop report
  publication-title: NPJ Vaccines
  doi: 10.1038/s41541-023-00654-6
– volume: 78
  start-page: 338
  year: 2023
  end-page: 348
  ident: CR6
  article-title: Clinical epidemiology and risk factors for critical outcomes among vaccinated and unvaccinated adults hospitalized with COVID-19—VISION Network, 10 States, June 2021–March 2023
  publication-title: Clin. Infect. Dis.
  doi: 10.1093/cid/ciad505
– volume: 374
  start-page: 1343
  year: 2021
  end-page: 1353
  ident: CR37
  article-title: Protection against SARS-CoV-2 Beta variant in mRNA-1273 vaccine-boosted nonhuman primates
  publication-title: Science
  doi: 10.1126/science.abl8912
– volume: 87
  start-page: 7793
  year: 2013
  end-page: 7804
  ident: CR69
  article-title: Recombinant IgA is sufficient to prevent influenza virus transmission in guinea pigs
  publication-title: J. Virol.
  doi: 10.1128/JVI.00979-13
– volume: 14
  year: 2022
  ident: CR77
  article-title: Escape from recognition of SARS-CoV-2 variant spike epitopes but overall preservation of T cell immunity
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.abj6824
– volume: 25
  start-page: 537
  year: 2024
  end-page: 551
  ident: CR32
  article-title: Mucosal vaccine-induced cross-reactive CD8(.) T cells protect against SARS-CoV-2 XBB.1.5 respiratory tract infection
  publication-title: Nat. Immunol.
  doi: 10.1038/s41590-024-01743-x
– volume: 21
  start-page: 162
  year: 2023
  end-page: 177
  ident: CR14
  article-title: SARS-CoV-2 variant biology: immune escape, transmission and fitness
  publication-title: Nat. Rev. Microbiol.
– volume: 185
  start-page: 1025
  year: 2022
  end-page: 1040
  ident: CR16
  article-title: Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination
  publication-title: Cell
  doi: 10.1016/j.cell.2022.01.018
– volume: 14
  year: 2023
  ident: CR12
  article-title: Characterizing SARS-CoV-2 neutralization profiles after bivalent boosting using antigenic cartography
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-023-41049-4
– volume: 131
  start-page: e116
  year: 2020
  ident: CR98
  article-title: Development of a rapid focus reduction neutralization test assay for measuring SARS-CoV-2 neutralizing antibodies
  publication-title: Curr. Protoc. Immunol.
  doi: 10.1002/cpim.116
– volume: 385
  start-page: 2010
  year: 2021
  end-page: 2012
  ident: CR51
  article-title: Differential kinetics of immune responses elicited by COVID-19 vaccines
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMc2115596
– volume: 184
  start-page: 1804
  year: 2021
  end-page: 1820
  ident: CR47
  article-title: Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection
  publication-title: Cell
  doi: 10.1016/j.cell.2021.02.026
– volume: 9
  year: 2023
  ident: CR22
  article-title: Intranasal mRNA-LNP vaccination protects hamsters from SARS-CoV-2 infection
  publication-title: Sci. Adv.
  doi: 10.1126/sciadv.adh1655
– volume: 185
  start-page: 113
  year: 2022
  end-page: 130
  ident: CR35
  article-title: Protection from SARS-CoV-2 Delta one year after mRNA-1273 vaccination in rhesus macaques coincides with anamnestic antibody response in the lung
  publication-title: Cell
  doi: 10.1016/j.cell.2021.12.002
– volume: 374
  year: 2021
  ident: CR61
  article-title: Low-dose mRNA-1273 COVID-19 vaccine generates durable memory enhanced by cross-reactive T cells
  publication-title: Science
  doi: 10.1126/science.abj9853
– volume: 385
  start-page: 664
  year: 2021
  end-page: 666
  ident: CR97
  article-title: Infection and vaccine-induced neutralizing-antibody responses to the SARS-CoV-2 B.1.617 variants
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMc2107799
– volume: 342
  start-page: 592
  year: 2013
  end-page: 598
  ident: CR82
  article-title: Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus
  publication-title: Science
  doi: 10.1126/science.1243283
– volume: 19
  start-page: 447
  year: 2022
  end-page: 448
  ident: CR78
  article-title: T cell epitopes in SARS-CoV-2 proteins are substantially conserved in the Omicron variant
  publication-title: Cell. Mol. Immunol.
  doi: 10.1038/s41423-022-00838-5
– volume: 373
  start-page: eabj0299
  year: 2021
  ident: CR10
  article-title: Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates
  publication-title: Science
  doi: 10.1126/science.abj0299
– volume: 183
  start-page: 996
  year: 2020
  end-page: 1012
  ident: CR65
  article-title: Antigen-specific adaptive immunity to SARS-CoV-2 in acute COVID-19 and associations with age and disease severity
  publication-title: Cell
  doi: 10.1016/j.cell.2020.09.038
– volume: 12
  start-page: e0006862
  year: 2018
  ident: CR99
  article-title: Viridot: an automated virus plaque (immunofocus) counter for the measurement of serological neutralizing responses with application to dengue virus
  publication-title: PLoS Negl. Trop. Dis.
  doi: 10.1371/journal.pntd.0006862
– volume: 388
  start-page: 1818
  year: 2023
  end-page: 1820
  ident: CR3
  article-title: Durability of bivalent boosters against omicron subvariants
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMc2302462
– volume: 369
  start-page: 1501
  year: 2020
  end-page: 1505
  ident: CR89
  article-title: Structure-based design of prefusion-stabilized SARS-CoV-2 spikes
  publication-title: Science
  doi: 10.1126/science.abd0826
– volume: 4
  start-page: e488
  year: 2023
  ident: CR56
  article-title: Mucosal immune responses following a fourth SARS-CoV-2 vaccine dose
  publication-title: Lancet Microbe
  doi: 10.1016/S2666-5247(23)00102-7
– volume: 21
  start-page: 1654
  year: 2021
  end-page: 1664
  ident: CR26
  article-title: Safety, tolerability, and immunogenicity of an aerosolised adenovirus type-5 vector-based COVID-19 vaccine (Ad5-nCoV) in adults: preliminary report of an open-label and randomised phase 1 clinical trial
  publication-title: Lancet Infect. Dis.
  doi: 10.1016/S1473-3099(21)00396-0
– volume: 22
  start-page: 1306
  year: 2021
  end-page: 1315
  ident: CR34
  article-title: mRNA-1273 protects against SARS-CoV-2 Beta infection in nonhuman primates
  publication-title: Nat. Immunol.
  doi: 10.1038/s41590-021-01021-0
– volume: 218
  start-page: e20201993
  year: 2021
  ident: CR48
  article-title: Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20201993
– volume: 185
  start-page: 847
  year: 2022
  end-page: 859
  ident: CR62
  article-title: SARS-CoV-2 vaccination induces immunological T cell memory able to cross-recognize variants from Alpha to Omicron
  publication-title: Cell
  doi: 10.1016/j.cell.2022.01.015
– volume: 8
  start-page: 569
  year: 2023
  end-page: 580
  ident: CR45
  article-title: Fc-γR-dependent antibody effector functions are required for vaccine-mediated protection against antigen-shifted variants of SARS-CoV-2
  publication-title: Nat. Microbiol.
  doi: 10.1038/s41564-023-01359-1
– volume: 388
  start-page: 183
  year: 2022
  end-page: 185
  ident: CR96
  article-title: Neutralization against BA.2.75.2, BQ.1.1, and XBB from mRNA bivalent booster
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMc2214293
– volume: 36
  year: 2021
  ident: CR31
  article-title: A single intranasal or intramuscular immunization with chimpanzee adenovirus-vectored SARS-CoV-2 vaccine protects against pneumonia in hamsters
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2021.109400
– volume: 17
  start-page: e0268767
  year: 2022
  ident: CR100
  article-title: Molecular probes of spike ectodomain and its subdomains for SARS-CoV-2 variants, Alpha through Omicron
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0268767
– volume: 29
  start-page: 9391
  year: 2011
  end-page: 9397
  ident: CR80
  article-title: A randomized, double-blind noninferiority study of quadrivalent live attenuated influenza vaccine in adults
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2011.09.109
– volume: 29
  start-page: 516
  year: 2021
  end-page: 521
  ident: CR93
  article-title: Infection- and vaccine-induced antibody binding and neutralization of the B.1.351 SARS-CoV-2 variant
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2021.03.009
– volume: 386
  start-page: 340
  year: 2022
  end-page: 350
  ident: CR1
  article-title: Duration of protection against mild and severe disease by COVID-19 vaccines
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa2115481
– volume: 184
  start-page: 2372
  year: 2021
  end-page: 2383
  ident: CR13
  article-title: Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity
  publication-title: Cell
  doi: 10.1016/j.cell.2021.03.013
– volume: 184
  start-page: 3467
  year: 2021
  ident: 1951_CR11
  publication-title: Cell
  doi: 10.1016/j.cell.2021.05.040
– volume: 375
  start-page: 43
  year: 2022
  ident: 1951_CR66
  publication-title: Science
  doi: 10.1126/science.abm3425
– volume: 14
  year: 2023
  ident: 1951_CR39
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-023-37715-2
– volume: 14
  year: 2022
  ident: 1951_CR77
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.abj6824
– volume: 374
  year: 2021
  ident: 1951_CR61
  publication-title: Science
  doi: 10.1126/science.abj9853
– volume: 78
  start-page: 338
  year: 2023
  ident: 1951_CR6
  publication-title: Clin. Infect. Dis.
  doi: 10.1093/cid/ciad505
– volume: 14
  year: 2023
  ident: 1951_CR12
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-023-41049-4
– volume: 386
  start-page: 1712
  year: 2022
  ident: 1951_CR44
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa2201570
– volume: 21
  start-page: 1654
  year: 2021
  ident: 1951_CR26
  publication-title: Lancet Infect. Dis.
  doi: 10.1016/S1473-3099(21)00396-0
– volume: 369
  start-page: 1501
  year: 2020
  ident: 1951_CR89
  publication-title: Science
  doi: 10.1126/science.abd0826
– volume: 4
  year: 2019
  ident: 1951_CR74
  publication-title: NPJ Vaccines
  doi: 10.1038/s41541-019-0113-9
– volume: 367
  start-page: 1260
  year: 2020
  ident: 1951_CR87
  publication-title: Science
  doi: 10.1126/science.abb2507
– volume: 185
  start-page: 1025
  year: 2022
  ident: 1951_CR16
  publication-title: Cell
  doi: 10.1016/j.cell.2022.01.018
– volume: 183
  start-page: 169
  year: 2020
  ident: 1951_CR29
  publication-title: Cell
  doi: 10.1016/j.cell.2020.08.026
– volume: 13
  year: 2022
  ident: 1951_CR42
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-022-33985-4
– volume: 184
  start-page: 1804
  year: 2021
  ident: 1951_CR47
  publication-title: Cell
  doi: 10.1016/j.cell.2021.02.026
– volume: 193
  start-page: 1799
  year: 2014
  ident: 1951_CR75
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1400676
– volume: 385
  start-page: 2485
  year: 2021
  ident: 1951_CR8
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMc2115597
– volume: 36
  start-page: 141
  year: 2021
  ident: 1951_CR94
  publication-title: Virol. Sin.
  doi: 10.1007/s12250-020-00230-5
– volume: 183
  start-page: 1024
  year: 2020
  ident: 1951_CR59
  publication-title: Cell
  doi: 10.1016/j.cell.2020.09.037
– volume: 374
  start-page: 1343
  year: 2021
  ident: 1951_CR37
  publication-title: Science
  doi: 10.1126/science.abl8912
– volume: 383
  start-page: 1544
  year: 2020
  ident: 1951_CR91
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa2024671
– volume: 14
  year: 2023
  ident: 1951_CR2
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-023-35815-7
– volume: 185
  start-page: 113
  year: 2022
  ident: 1951_CR35
  publication-title: Cell
  doi: 10.1016/j.cell.2021.12.002
– volume: 7
  start-page: eadd4853
  year: 2022
  ident: 1951_CR67
  publication-title: Sci. Immunol.
  doi: 10.1126/sciimmunol.add4853
– volume: 39
  start-page: 3081
  year: 2021
  ident: 1951_CR86
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2020.09.018
– volume: 12
  year: 2021
  ident: 1951_CR84
  publication-title: mBio
  doi: 10.1128/mBio.02527-21
– volume: 69
  start-page: 2328
  year: 2001
  ident: 1951_CR72
  publication-title: Infect. Immun.
  doi: 10.1128/IAI.69.4.2328-2338.2001
– volume: 615
  start-page: 482
  year: 2023
  ident: 1951_CR55
  publication-title: Nature
  doi: 10.1038/s41586-023-05715-3
– volume: 388
  start-page: 1818
  year: 2023
  ident: 1951_CR3
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMc2302462
– volume: 76
  start-page: e172
  year: 2023
  ident: 1951_CR5
  publication-title: Clin. Infect. Dis.
  doi: 10.1093/cid/ciac571
– volume: 385
  start-page: 1474
  year: 2021
  ident: 1951_CR9
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa2109072
– volume: 8
  start-page: 569
  year: 2023
  ident: 1951_CR45
  publication-title: Nat. Microbiol.
  doi: 10.1038/s41564-023-01359-1
– volume: 385
  start-page: 664
  year: 2021
  ident: 1951_CR97
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMc2107799
– volume: 373
  start-page: eabj0299
  year: 2021
  ident: 1951_CR10
  publication-title: Science
  doi: 10.1126/science.abj0299
– volume: 21
  start-page: 162
  year: 2023
  ident: 1951_CR14
  publication-title: Nat. Rev. Microbiol.
– volume: 218
  start-page: e20201993
  year: 2021
  ident: 1951_CR48
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20201993
– volume: 10
  start-page: 2199
  year: 2014
  ident: 1951_CR76
  publication-title: Hum. Vaccin. Immunother.
  doi: 10.4161/hv.29108
– volume: 109
  start-page: 2485
  year: 2012
  ident: 1951_CR53
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1115369109
– volume: 184
  start-page: 2316
  year: 2021
  ident: 1951_CR46
  publication-title: Cell
  doi: 10.1016/j.cell.2021.03.029
– volume: 626
  start-page: 385
  year: 2023
  ident: 1951_CR27
  publication-title: Nature
  doi: 10.1038/s41586-023-06951-3
– volume: 28
  start-page: 2398
  year: 2022
  ident: 1951_CR4
  publication-title: Nat. Med.
  doi: 10.1038/s41591-022-02051-3
– volume: 95
  start-page: 261
  year: 2019
  ident: 1951_CR102
  publication-title: Cytometry A
  doi: 10.1002/cyto.a.23670
– volume: 15
  start-page: 1
  year: 2019
  ident: 1951_CR88
  publication-title: Mol. Ther. Nucleic Acids
  doi: 10.1016/j.omtn.2019.01.013
– volume: 131
  start-page: e116
  year: 2020
  ident: 1951_CR98
  publication-title: Curr. Protoc. Immunol.
  doi: 10.1002/cpim.116
– volume: 29
  start-page: 247
  year: 2023
  ident: 1951_CR54
  publication-title: Nat. Med.
  doi: 10.1038/s41591-022-02092-8
– volume: 114
  start-page: E7348
  year: 2017
  ident: 1951_CR83
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1707304114
– volume: 385
  start-page: 2010
  year: 2021
  ident: 1951_CR51
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMc2115596
– volume: 585
  start-page: 268
  year: 2020
  ident: 1951_CR40
  publication-title: Nature
  doi: 10.1038/s41586-020-2324-7
– volume: 20
  start-page: 97
  year: 2019
  ident: 1951_CR52
  publication-title: Nat. Immunol.
  doi: 10.1038/s41590-018-0260-6
– volume: 185
  start-page: 847
  year: 2022
  ident: 1951_CR62
  publication-title: Cell
  doi: 10.1016/j.cell.2022.01.015
– volume: 87
  start-page: 104402
  year: 2023
  ident: 1951_CR57
  publication-title: EBioMedicine
  doi: 10.1016/j.ebiom.2022.104402
– volume: 373
  start-page: 1372
  year: 2021
  ident: 1951_CR49
  publication-title: Science
  doi: 10.1126/science.abj4176
– volume: 17
  start-page: e0268767
  year: 2022
  ident: 1951_CR100
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0268767
– volume: 377
  start-page: eabq1841
  year: 2022
  ident: 1951_CR15
  publication-title: Science
  doi: 10.1126/science.abq1841
– volume: 385
  start-page: 951
  year: 2021
  ident: 1951_CR50
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMc2108829
– volume: 617
  start-page: 592
  year: 2023
  ident: 1951_CR17
  publication-title: Nature
  doi: 10.1038/s41586-023-06025-4
– volume: 13
  start-page: eabi4547
  year: 2021
  ident: 1951_CR58
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.abi4547
– volume: 30
  start-page: 41
  year: 2022
  ident: 1951_CR68
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2021.11.006
– volume: 185
  start-page: 1549
  year: 2022
  ident: 1951_CR38
  publication-title: Cell
  doi: 10.1016/j.cell.2022.03.024
– volume: 28
  start-page: 1063
  year: 2022
  ident: 1951_CR43
  publication-title: Nat. Med.
  doi: 10.1038/s41591-022-01753-y
– volume: 9
  year: 2023
  ident: 1951_CR22
  publication-title: Sci. Adv.
  doi: 10.1126/sciadv.adh1655
– volume: 8
  year: 2023
  ident: 1951_CR28
  publication-title: NPJ Vaccines
  doi: 10.1038/s41541-023-00717-8
– volume: 377
  start-page: 821
  year: 2022
  ident: 1951_CR64
  publication-title: Science
  doi: 10.1126/science.add2897
– volume: 325
  start-page: 1896
  year: 2021
  ident: 1951_CR95
  publication-title: JAMA
  doi: 10.1001/jama.2021.4388
– volume: 8
  year: 2023
  ident: 1951_CR41
  publication-title: Sci. Immunol.
  doi: 10.1126/sciimmunol.adg7015
– volume: 185
  start-page: 1556
  year: 2022
  ident: 1951_CR36
  publication-title: Cell
  doi: 10.1016/j.cell.2022.03.038
– volume: 87
  start-page: 7793
  year: 2013
  ident: 1951_CR69
  publication-title: J. Virol.
  doi: 10.1128/JVI.00979-13
– volume: 387
  start-page: 1333
  year: 2022
  ident: 1951_CR19
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMc2209651
– volume: 378
  year: 2022
  ident: 1951_CR21
  publication-title: Science
  doi: 10.1126/science.abo2523
– volume: 36
  year: 2021
  ident: 1951_CR31
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2021.109400
– volume: 388
  start-page: 183
  year: 2022
  ident: 1951_CR96
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMc2214293
– volume: 22
  start-page: 1306
  year: 2021
  ident: 1951_CR34
  publication-title: Nat. Immunol.
  doi: 10.1038/s41590-021-01021-0
– volume: 8
  year: 2023
  ident: 1951_CR24
  publication-title: NPJ Vaccines
  doi: 10.1038/s41541-023-00662-6
– volume: 185
  start-page: 4811
  year: 2022
  ident: 1951_CR23
  publication-title: Cell
  doi: 10.1016/j.cell.2022.11.006
– volume: 183
  start-page: 996
  year: 2020
  ident: 1951_CR65
  publication-title: Cell
  doi: 10.1016/j.cell.2020.09.038
– volume: 12
  start-page: e0006862
  year: 2018
  ident: 1951_CR99
  publication-title: PLoS Negl. Trop. Dis.
  doi: 10.1371/journal.pntd.0006862
– volume: 8
  year: 2023
  ident: 1951_CR18
  publication-title: NPJ Vaccines
  doi: 10.1038/s41541-023-00654-6
– volume: 55
  start-page: 2118
  year: 2022
  ident: 1951_CR73
  publication-title: Immunity
  doi: 10.1016/j.immuni.2022.08.017
– volume: 386
  start-page: 340
  year: 2022
  ident: 1951_CR1
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa2115481
– volume: 36
  start-page: 115
  year: 1968
  ident: 1951_CR90
  publication-title: Virology
  doi: 10.1016/0042-6822(68)90121-9
– volume: 7
  year: 2022
  ident: 1951_CR60
  publication-title: Sci. Immunol.
  doi: 10.1126/sciimmunol.abq7647
– volume: 342
  start-page: 592
  year: 2013
  ident: 1951_CR82
  publication-title: Science
  doi: 10.1126/science.1243283
– volume: 107
  start-page: 22213
  year: 2010
  ident: 1951_CR92
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1015536108
– volume: 14
  year: 2022
  ident: 1951_CR85
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.abn1413
– volume: 387
  start-page: e55
  year: 2022
  ident: 1951_CR20
  publication-title: N. Engl. J. Med.
– volume: 19
  start-page: 447
  year: 2022
  ident: 1951_CR78
  publication-title: Cell. Mol. Immunol.
  doi: 10.1038/s41423-022-00838-5
– volume: 14
  start-page: 777
  year: 2015
  ident: 1951_CR79
  publication-title: J. Cyst. Fibros.
  doi: 10.1016/j.jcf.2015.04.003
– volume: 79
  start-page: 167
  year: 2011
  ident: 1951_CR101
  publication-title: Cytometry A
  doi: 10.1002/cyto.a.21015
– volume: 194
  start-page: 1597
  year: 2001
  ident: 1951_CR71
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.194.11.1597
– volume: 4
  start-page: e488
  year: 2023
  ident: 1951_CR56
  publication-title: Lancet Microbe
  doi: 10.1016/S2666-5247(23)00102-7
– volume: 36
  year: 2021
  ident: 1951_CR33
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2021.109452
– volume: 25
  start-page: 537
  year: 2024
  ident: 1951_CR32
  publication-title: Nat. Immunol.
  doi: 10.1038/s41590-024-01743-x
– volume: 29
  start-page: 516
  year: 2021
  ident: 1951_CR93
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2021.03.009
– volume: 85
  year: 2022
  ident: 1951_CR25
  publication-title: EBioMedicine
  doi: 10.1016/j.ebiom.2022.104298
– volume: 14
  year: 2023
  ident: 1951_CR63
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2023.1146841
– volume: 2
  year: 2021
  ident: 1951_CR30
  publication-title: Cell Rep. Med.
  doi: 10.1016/j.xcrm.2021.100230
– volume: 385
  year: 2021
  ident: 1951_CR7
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa2114228
– volume: 29
  start-page: 9391
  year: 2011
  ident: 1951_CR80
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2011.09.109
– volume: 184
  start-page: 2372
  year: 2021
  ident: 1951_CR13
  publication-title: Cell
  doi: 10.1016/j.cell.2021.03.013
– volume: 8
  start-page: 900
  year: 2017
  ident: 1951_CR70
  publication-title: Front. Microbiol.
  doi: 10.3389/fmicb.2017.00900
– volume: 14
  year: 2022
  ident: 1951_CR81
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.ade0424
– reference: 37986823 - bioRxiv. 2023 Nov 08:2023.11.06.565765. doi: 10.1101/2023.11.06.565765
SSID ssj0014764
Score 2.5254636
Snippet A mucosal route of vaccination could prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication at the site of infection and limit...
SourceID pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 1913
SubjectTerms 631/250/2152/2153/1571
631/250/347
631/250/590/1867
631/326/590/1867
631/326/596/4130
Adenoviridae - genetics
Adenoviridae - immunology
Adenovirus Vaccines - administration & dosage
Adenovirus Vaccines - immunology
Administration, Intranasal
Animals
Antibodies, Neutralizing - blood
Antibodies, Neutralizing - immunology
Antibodies, Viral - blood
Antibodies, Viral - immunology
B-Lymphocytes - immunology
Biomedical and Life Sciences
Biomedicine
Coronaviruses
COVID-19
COVID-19 - immunology
COVID-19 - prevention & control
COVID-19 - virology
COVID-19 Vaccines - administration & dosage
COVID-19 Vaccines - immunology
Female
Humans
Immunity, Mucosal
Immunization, Secondary
Immunoglobulin A
Immunoglobulin A - immunology
Immunoglobulin G
Immunoglobulin G - blood
Immunoglobulin G - immunology
Immunology
Infections
Infectious Diseases
Lung - immunology
Lung - virology
Lymphocytes B
Lymphocytes T
Macaca mulatta
mRNA
Mucosa
Replication
Respiratory tract
SARS-CoV-2 - immunology
Severe acute respiratory syndrome coronavirus 2
Spike Glycoprotein, Coronavirus - genetics
Spike Glycoprotein, Coronavirus - immunology
Vaccination - methods
Vaccines
Title Mucosal adenovirus vaccine boosting elicits IgA and durably prevents XBB.1.16 infection in nonhuman primates
URI https://link.springer.com/article/10.1038/s41590-024-01951-5
https://www.ncbi.nlm.nih.gov/pubmed/39227514
https://www.proquest.com/docview/3110556413
https://www.proquest.com/docview/3100560904
https://pubmed.ncbi.nlm.nih.gov/PMC11436372
Volume 25
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1La9wwEB7ShJZeSpu-nKZBhd5apbIkv467S5e0sDk1sDejl9uFrTesdwP59xnJj7BJG8jNoLFlezSaT8zMNwCfmbCpypXf_ayksqgUVUZKyoQ2zNlEmUD2PDtPzy7kz3ky3wPe18KEpP1AaRm26T477FuDjqZgFD0K9SVuMU2ewIGnbverepJOhsiBzAJlFLqlgvKC5V2hDBP5P56x64zuIcz7iZJ3oqXBCU1fwosOPZJR-76vYM_Vh_C07Sd5fQjPZl2k_DUsZz4VHWUVbiyrq8V625ArZfwgQWDd-Gxn4pYovWnIj98jompL7Hat9PKaXLa8Tg2Zj8en8Wmckj5nq8YrUq_q0NoP5RZ_PVZ9AxfT778mZ7TrrECNzJINtQZRgElEkmo08srmaWUcHvW0dLHLNXOZrWIhUxs7tGhlEMZorrnNHAIsppR4C_s4l3sPJNFScFb5Imwhi5wrxDdCMutQ1Vmiqwji_heXpqMd990vlmUIf4u8bNVSolrKoJYyieDLcM9lS7rxoPRxr7myM8CmFHHo_IkuOoJPwzCajo-HqNqttl7GE6GygskI3rWKHqZD2MgzBJMR5DtLYBDwtNy7I_XiT6DnxhOmSEXGI_jar5bb9_r_Zxw9TvwDPOd-JYe8wmPY36y37iPio40-gYPRdDw-PwmGcQMoHAjE
linkProvider Springer Nature
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwEB6VIh4XBOUVKGAkbuDixHYex3ZFtYVuT620t8ivlJWWbLXZrdR_z9h5VNtSpN4ieRInGY_ns2bmG4AvjNtU5crvflZQUVSKKiMEZVwb5qxUJpA9T07S8Zn4OZXTLUj6WpiQtB8oLcM23WeHfW_Q0RSMokehvsQtpvIBPESsnfo0rlE6GiIHIguUUeiWCpoULO8KZRjP__GMTWd0C2HeTpS8ES0NTujwOTzr0CPZb9_3BWy5egcetf0kr3bg8aSLlL-E-cSnoqOswo1lcTlbrhtyqYwfJAisG5_tTNwcpVcNOTrfJ6q2xK6XSs-vyEXL69SQ6cHBXrwXp6TP2arxitSLOrT2Q7nZH49VX8HZ4Y_T0Zh2nRWoEZlcUWsQBRjJZarRyCubp5VxeNTTwsUu18xltoq5SG3s0KKVQRijE53YzCHAYkrx17CNc7m3QKQWPGGVL8LmosgThfiGC2YdqjqTuoog7n9xaTracd_9Yl6G8DfPy1YtJaqlDGopZQRfh3suWtKN_0rv9porOwNsSh6Hzp_ooiP4PAyj6fh4iKrdYu1lPBEqK5iI4E2r6GE6hI1JhmAygnxjCQwCnpZ7c6Se_Q703HjC5CnPkgi-9avl-r3u_ox39xP_BE_Gp5Pj8vjo5Nd7eJr4VR1yDHdhe7Vcuw-IlVb6YzCOv3CLCjc
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3db9MwED-NISZeEIyvwAAj8QbunNhxksetUG1AJx6Y1LfIX4FKJa2adtL-e87OByoDJN4i-RInOZ_vZ93d7wDeMG6lypXf_aygoqgUVUYIyrg2zNlUmUD2PL2QZ5fi4yyd7YHsa2FC0n6gtAzbdJ8ddtygoykYRY9CfYlbTNPRyla34DbibeYPXWM5HqIHIgu0UeiaCpoULO-KZRjP__CcXYd0A2XeTJb8LWIaHNHkPtzrECQ5ad_5Aey5-hDutD0lrw_hYNpFyx_CYurT0VFW4eayvJqvtw25UsYPEgTXjc94Jm6B0puGnH87Iaq2xG7XSi-uyarldmrI7PR0FI9iSfq8rRqvSL2sQ3s_lJv_8Hj1EVxOPnwdn9GuuwI1Iks31BpEAiblqdRo6JXNZWUcHve0cLHLNXOZrWIupI0dWrUyCGV0ohObOQRZTCn-GPZxLvcUSKoFT1jlC7G5KPJEIcbhglmH6s5SXUUQ97-4NB31uO-AsShDCJznZauWEtVSBrWUaQRvh3tWLfHGP6WPes2VnRE2JY9D90900xG8HobRfHxMRNVuufUyngyVFUxE8KRV9DAdQsckQ0AZQb6zBAYBT829O1LPvweKbjxlcsmzJIJ3_Wr59V5__4xn_yf-Cg6-vJ-Un88vPj2Hu4lf1CHN8Aj2N-ute4FwaaNfBtv4CUIhC0A
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Mucosal+adenovirus+vaccine+boosting+elicits+IgA+and+durably+prevents+XBB.1.16+infection+in+nonhuman+primates&rft.jtitle=Nature+immunology&rft.au=Gagne%2C+Matthew&rft.au=Flynn%2C+Barbara+J.&rft.au=Andrew%2C+Shayne+F.&rft.au=Marquez%2C+Josue&rft.date=2024-10-01&rft.issn=1529-2908&rft.eissn=1529-2916&rft.volume=25&rft.issue=10&rft.spage=1913&rft.epage=1927&rft_id=info:doi/10.1038%2Fs41590-024-01951-5&rft.externalDBID=n%2Fa&rft.externalDocID=10_1038_s41590_024_01951_5
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1529-2908&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1529-2908&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1529-2908&client=summon