Interaction between Neuromelanin and Alpha-Synuclein in Parkinson's Disease

• Published in: Biomolecules (Basel, Switzerland) Vol. 5; no. 2; pp. 1122 - 1142
• Main Authors: Xu, Shengli, Chan, Piu
• Format: Journal Article Book Review
• Language: English
• Published: Switzerland MDPI AG 05.06.2015; MDPI
• Subjects: alpha-synuclein; alpha-Synuclein - genetics; alpha-Synuclein - metabolism; Animals; Humans; Melanins - metabolism; neuromelanin; Oxidative Stress; Parkinson Disease - metabolism; Parkinson Disease - pathology; Parkinson's disease; Protein Aggregation, Pathological - metabolism; Review; alpha-synuclein; Parkinson’s disease; oxidative stress; neuromelanin

Parkinson's disease (PD) is a very common neurodegenerative disorder characterized by the accumulation of α-synuclein (α-syn) into Lewy body (LB) inclusions and the loss of neuronmelanin (NM) containing dopamine (DA) neurons in the substantia nigra (SN). Pathological α-syn and NM are two promin...