Textural heterogeneity of liver lesions in CT imaging - comparison of colorectal and pancreatic metastases

• Published in: Abdominal imaging Vol. 49; no. 12; pp. 4295 - 4306
• Main Authors: Pietsch, Friedrich L., Haag, Florian, Ayx, Isabelle, Grawe, Freba, Vellala, Abhinay K., Schoenberg, Stefan O., Froelich, Matthias F., Tharmaseelan, Hishan
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.12.2024; Springer Nature B.V
• Subjects: Adult; Aged; Aged, 80 and over; Cancer; Cancer therapies; Coefficient of variation; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - diagnostic imaging; Colorectal Neoplasms - pathology; Computed tomography; Contrast Media; Drug resistance; Female; Gastroenterology; Hepatobiliary; Hepatology; Heterogeneity; Humans; Image contrast; Image enhancement; Imaging; Lesions; Liver; Liver cancer; Liver Neoplasms - diagnostic imaging; Liver Neoplasms - secondary; Male; Malignancy; Medical imaging; Medicine; Medicine & Public Health; Metastases; Metastasis; Middle Aged; Pancreatic cancer; Pancreatic Neoplasms - diagnostic imaging; Pancreatic Neoplasms - pathology; Radiographic Image Interpretation, Computer-Assisted - methods; Radiology; Radiomics; Retrospective Studies; Tomography, X-Ray Computed - methods; Tumor/Oncology; Computed tomography; Pancreas; Colorectum; Tumoral Heterogeneity; Radiomics

Purpose Tumoral heterogeneity poses a challenge for personalized cancer treatments. Especially in metastasized cancer, it remains a major limitation for successful targeted therapy, often leading to drug resistance due to tumoral escape mechanisms. This work explores a non-invasive radiomics-based a...