The IL-27 Receptor (WSX-1) Is an Inhibitor of Innate and Adaptive Elements of Type 2 Immunity

• Published in: The Journal of immunology (1950) Vol. 173; no. 9; pp. 5626 - 5634
• Main Authors: Artis, David, Villarino, Alejandro, Silverman, Michael, He, Weimian, Thornton, Elizabeth M, Mu, Sharon, Summer, Shamin, Covey, Todd M, Huang, Elaine, Yoshida, Hiroki, Koretzky, Gary, Goldschmidt, Michael, Wu, Gary D, de Sauvage, Fred, Miller, Hugh R. P, Saris, Christiaan J. M, Scott, Phillip, Hunter, Christopher A
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 01.11.2004
• Subjects: Animals; Cytokines - biosynthesis; Down-Regulation - immunology; Goblet Cells - immunology; Goblet Cells - pathology; Immunity, Innate - genetics; Immunity, Mucosal - genetics; Interferon-gamma - antagonists & inhibitors; Interferon-gamma - biosynthesis; Interleukins - biosynthesis; Interleukins - genetics; Interleukins - physiology; Intestinal Diseases, Parasitic - genetics; Intestinal Diseases, Parasitic - immunology; Intestinal Diseases, Parasitic - pathology; Mastocytosis - genetics; Mastocytosis - immunology; Mastocytosis - pathology; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Cytokine - deficiency; Receptors, Cytokine - genetics; Receptors, Cytokine - physiology; RNA, Messenger - biosynthesis; Suppressor Factors, Immunologic - deficiency; Suppressor Factors, Immunologic - genetics; Suppressor Factors, Immunologic - physiology; Th2 Cells - immunology; Th2 Cells - metabolism; Th2 Cells - parasitology; Trichuriasis - genetics; Trichuriasis - immunology; Trichuriasis - parasitology; Trichuriasis - pathology; Trichuris - growth & development; Trichuris - immunology

Although previous studies have investigated the role of IL-27/WSX-1 interactions in the regulation of Th1 responses, little is known about their role in regulating Th2-type responses. Studies presented in this work identify a direct role for IL-27/WSX-1 interactions in the negative regulation of typ...