Designing alginate hydrogels to maintain viability of immobilized cells

• Published in: Biomaterials Vol. 24; no. 22; pp. 4023 - 4029
• Main Authors: Kong, Hyun Joon, Smith, Molly K., Mooney, David J.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.10.2003
• Subjects: Alginate; Alginates - chemistry; Biocompatible Materials - chemistry; Cell Survival; Cell viability; Dose-Response Relationship, Drug; Elastic moduli; Glucuronic Acid - chemistry; Guluronic acid blocks; Hexuronic Acids - chemistry; Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry; Molecular Weight; Oligopeptides - chemistry; Polymers - chemistry; Rheological property; Rheological property; Elastic moduli; Cell viability; Alginate; Guluronic acid blocks

Hydrogel-forming materials have been widely utilized as an immobilization matrix and transport vehicle for cells. Success in these applications is dependent upon maintaining cell viability through the gel preparation process. We hypothesized that the high viscosity of pre-gelled solutions typically...