Immunometabolic alteration of CD4+ T cells in the pathogenesis of primary Sjögren’s syndrome

• Published in: Clinical and experimental medicine Vol. 24; no. 1; p. 163
• Main Authors: Chen, Yingying, Luo, Xuan, Deng, Chuiwen, Zhao, Lidan, Gao, Hui, Zhou, Jiaxin, Peng, Linyi, Yang, Huaxia, Li, Mengtao, Zhang, Wen, Zhao, Yan, Fei, Yunyun
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 22.07.2024; Springer Nature B.V
• Subjects: Adult; AKT1 protein; CD28 antigen; CD4 antigen; CD4-Positive T-Lymphocytes - immunology; CD4-Positive T-Lymphocytes - metabolism; Cell Differentiation; Effector cells; Female; Flow cytometry; Glucose; Glycolysis; Helper cells; Hematology; Humans; Interferon-gamma - metabolism; Interleukin-17 - metabolism; Internal Medicine; Intracellular; Lymphocytes; Lymphocytes T; Male; Medicine; Medicine & Public Health; Middle Aged; Myc protein; Oncology; Oxidative phosphorylation; Pathogenesis; Phenotypes; Phosphorylation; Reactive oxygen species; Reactive Oxygen Species - metabolism; Sjogren's syndrome; Sjogren's Syndrome - immunology; Sjogren's Syndrome - metabolism; Sjogren's Syndrome - pathology; Th1 Cells - immunology; Th17 Cells - immunology; Therapeutic targets; TOR protein; Transcriptomes; Western blotting; γ-Interferon; Aerobic glycolysis; CD4; Reactive oxygen species; T cells; Primary Sjögren’s syndrome; Lactate dehydrogenase A; CD4+ T cells

Primary Sjögren’s syndrome (pSS) is a prevalent autoimmune disorder wherein CD4 + T cells play a pivotal role in its pathogenesis. However, the underlying mechanisms driving the hyperactivity of CD4 + T cells in pSS remain poorly understood. This study aimed to investigate the potential role of immu...