Cytokine Signaling and Matrix Remodeling Pathways Associated with Cardiac Sarcoidosis Disease Activity Defined Using FDG PET Imaging

• Published in: International Heart Journal Vol. 62; no. 5; pp. 1096 - 1105
• Main Authors: Young, Bryan D., Moreland, Hannah, Oatmen, Kelsie E., Freeburg, Lisa A., Shahab, Zartashia, Herzog, Erica, Miller, Edward J., Spinale, Francis G.
• Format: Journal Article
• Language: English
• Published: Tokyo International Heart Journal Association 29.09.2021; Japan Science and Technology Agency
• Subjects: Biomarkers; Biopsy; Congestive heart failure; Coronary artery disease; Cytokine receptors; Cytokines; FDG PET/CT; Gelatinase B; Growth factor receptors; IL-2; Inflammation; Matrix metalloproteinase; Metalloproteinase; MMP; Patients; Plasma; Positron emission tomography; Proteases; Proteolysis; Receptor mechanisms; Risk assessment; Sarcoidosis; TIMP; Tissue inhibitor of metalloproteinases; TNFα; Tumor necrosis factor; Tumor necrosis factor receptors; Tumor necrosis factor-TNF; Vascular endothelial growth factor; Vascular endothelial growth factor receptors

While cardiac imaging has improved the diagnosis and risk assessment for cardiac sarcoidosis (CS), treatment regimens have consisted of generalized heart failure therapies and non-specific anti-inflammatory regimens. The overall goal of this study was to perform high-sensitivity plasma profiling of...