Family Cluster of Middle East Respiratory Syndrome Coronavirus Infections
A novel coronavirus (MERS-CoV) was recently identified as the cause of severe respiratory disease. In this report from Saudi Arabia, a family cluster of infection over a 6-week period is described, suggesting possible limited person-to-person transmission. MERS-CoV was first reported in September 20...
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| Published in | The New England journal of medicine Vol. 368; no. 26; pp. 2487 - 2494 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Waltham, MA
Massachusetts Medical Society
27.06.2013
|
| Series | Brief Report |
| Subjects | |
| Online Access | Get full text |
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| Abstract | A novel coronavirus (MERS-CoV) was recently identified as the cause of severe respiratory disease. In this report from Saudi Arabia, a family cluster of infection over a 6-week period is described, suggesting possible limited person-to-person transmission.
MERS-CoV was first reported in September 2012 in samples obtained from a Saudi Arabian businessman who died from acute respiratory and renal failure.
1
As of May 28, 2013, a total of 49 cases of human MERS-CoV infection with 26 deaths have been reported to the World Health Organization (WHO). MERS-CoV is the first betacoronavirus belonging to lineage C that is known to infect humans.
2
It belongs to the Coronaviridae family, a group of large, enveloped single-stranded RNA viruses that are known for their genomic plasticity and their ability to cause a range of infections in mammalian and avian hosts. MERS-CoV . . . |
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| AbstractList | A human coronavirus, called the Middle East respiratory syndrome coronavirus (MERS-CoV), was first identified in September 2012 in samples obtained from a Saudi Arabian businessman who died from acute respiratory failure. Since then, 49 cases of infections caused by MERS-CoV (previously called a novel coronavirus) with 26 deaths have been reported to date. In this report, we describe a family case cluster of MERS-CoV infection, including the clinical presentation, treatment outcomes, and household relationships of three young men who became ill with MERS-CoV infection after the hospitalization of an elderly male relative, who died of the disease. Twenty-four other family members living in the same household and 124 attending staff members at the hospitals did not become ill. MERS-CoV infection may cause a spectrum of clinical illness. Although an animal reservoir is suspected, none has been discovered. Meanwhile, global concern rests on the ability of MERS-CoV to cause major illness in close contacts of patients. A novel coronavirus (MERS-CoV) was recently identified as the cause of severe respiratory disease. In this report from Saudi Arabia, a family cluster of infection over a 6-week period is described, suggesting possible limited person-to-person transmission. MERS-CoV was first reported in September 2012 in samples obtained from a Saudi Arabian businessman who died from acute respiratory and renal failure. 1 As of May 28, 2013, a total of 49 cases of human MERS-CoV infection with 26 deaths have been reported to the World Health Organization (WHO). MERS-CoV is the first betacoronavirus belonging to lineage C that is known to infect humans. 2 It belongs to the Coronaviridae family, a group of large, enveloped single-stranded RNA viruses that are known for their genomic plasticity and their ability to cause a range of infections in mammalian and avian hosts. MERS-CoV . . . A human coronavirus, called the Middle East respiratory syndrome coronavirus (MERS-CoV), was first identified in September 2012 in samples obtained from a Saudi Arabian businessman who died from acute respiratory failure. Since then, 49 cases of infections caused by MERS-CoV (previously called a novel coronavirus) with 26 deaths have been reported to date. In this report, we describe a family case cluster of MERS-CoV infection, including the clinical presentation, treatment outcomes, and household relationships of three young men who became ill with MERS-CoV infection after the hospitalization of an elderly male relative, who died of the disease. Twenty-four other family members living in the same household and 124 attending staff members at the hospitals did not become ill. MERS-CoV infection may cause a spectrum of clinical illness. Although an animal reservoir is suspected, none has been discovered. Meanwhile, global concern rests on the ability of MERS-CoV to cause major illness in close contacts of patients.A human coronavirus, called the Middle East respiratory syndrome coronavirus (MERS-CoV), was first identified in September 2012 in samples obtained from a Saudi Arabian businessman who died from acute respiratory failure. Since then, 49 cases of infections caused by MERS-CoV (previously called a novel coronavirus) with 26 deaths have been reported to date. In this report, we describe a family case cluster of MERS-CoV infection, including the clinical presentation, treatment outcomes, and household relationships of three young men who became ill with MERS-CoV infection after the hospitalization of an elderly male relative, who died of the disease. Twenty-four other family members living in the same household and 124 attending staff members at the hospitals did not become ill. MERS-CoV infection may cause a spectrum of clinical illness. Although an animal reservoir is suspected, none has been discovered. Meanwhile, global concern rests on the ability of MERS-CoV to cause major illness in close contacts of patients. |
| Author | Zumla, Alimuddin I Stephens, Gwen M Al-Hakeem, Rafat F Memish, Ziad A Al-Rabeeah, Abdullah A |
| Author_xml | – sequence: 1 givenname: Ziad A surname: Memish fullname: Memish, Ziad A organization: From the Global Center for Mass Gatherings Medicine (Z.A.M., A.I.Z., R.F.A.-H., A.A.A.-R., G.M.S.), the Ministry of Health (Z.A.M., R.F.A.-H., A.A.A.-R., G.M.S.), and Al-Faisal University (Z.A.M.) — all in Riyadh, Saudi Arabia; and the Division of Infection and Immunity, University College London, and Department of Medical Microbiology, UCL Hospitals NHS Foundation Trust, London (A.I.Z.) – sequence: 2 givenname: Alimuddin I surname: Zumla fullname: Zumla, Alimuddin I organization: From the Global Center for Mass Gatherings Medicine (Z.A.M., A.I.Z., R.F.A.-H., A.A.A.-R., G.M.S.), the Ministry of Health (Z.A.M., R.F.A.-H., A.A.A.-R., G.M.S.), and Al-Faisal University (Z.A.M.) — all in Riyadh, Saudi Arabia; and the Division of Infection and Immunity, University College London, and Department of Medical Microbiology, UCL Hospitals NHS Foundation Trust, London (A.I.Z.) – sequence: 3 givenname: Rafat F surname: Al-Hakeem fullname: Al-Hakeem, Rafat F organization: From the Global Center for Mass Gatherings Medicine (Z.A.M., A.I.Z., R.F.A.-H., A.A.A.-R., G.M.S.), the Ministry of Health (Z.A.M., R.F.A.-H., A.A.A.-R., G.M.S.), and Al-Faisal University (Z.A.M.) — all in Riyadh, Saudi Arabia; and the Division of Infection and Immunity, University College London, and Department of Medical Microbiology, UCL Hospitals NHS Foundation Trust, London (A.I.Z.) – sequence: 4 givenname: Abdullah A surname: Al-Rabeeah fullname: Al-Rabeeah, Abdullah A organization: From the Global Center for Mass Gatherings Medicine (Z.A.M., A.I.Z., R.F.A.-H., A.A.A.-R., G.M.S.), the Ministry of Health (Z.A.M., R.F.A.-H., A.A.A.-R., G.M.S.), and Al-Faisal University (Z.A.M.) — all in Riyadh, Saudi Arabia; and the Division of Infection and Immunity, University College London, and Department of Medical Microbiology, UCL Hospitals NHS Foundation Trust, London (A.I.Z.) – sequence: 5 givenname: Gwen M surname: Stephens fullname: Stephens, Gwen M organization: From the Global Center for Mass Gatherings Medicine (Z.A.M., A.I.Z., R.F.A.-H., A.A.A.-R., G.M.S.), the Ministry of Health (Z.A.M., R.F.A.-H., A.A.A.-R., G.M.S.), and Al-Faisal University (Z.A.M.) — all in Riyadh, Saudi Arabia; and the Division of Infection and Immunity, University College London, and Department of Medical Microbiology, UCL Hospitals NHS Foundation Trust, London (A.I.Z.) |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27428062$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/23718156$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | Copyright © 2013 Massachusetts Medical Society. All rights reserved. 2014 INIST-CNRS |
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| Keywords | Virus Medicine Coronavirus Respiratory disease Family study Family environment Cluster Coronaviridae Respiratory system infection Nidovirales Syndrome |
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| References | r008 r002 r003 r004 Zaki, AM, van Boheemen, S, Bestebroer, TM, Osterhaus, ADME, Fouchier, RAM (r001) 2012; 367 r005 Peiris, JS, Chu, CM, Cheng, VC (r006) 2003; 361 Wong, RS, Wu, A, To, KF (r009) 2003; 326 r010 r011 Albarrak, AM, Stephens, GM, Hewson, R, Memish, ZA (r007) 2012; 33 r006 r009 r001 Albarrak AM (r007) 2012; 33 N Engl J Med. 2013 Aug 8;369(6):587 |
| References_xml | – volume: 367 start-page: 1814 year: 2012 end-page: 1820 ident: r001 article-title: Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. publication-title: N Engl J Med – ident: r010 article-title: World Health Organization. Interim surveillance recommendations for human infection with novel coronavirus as of 18 March 2013 ( http://www.who.int/csr/disease/coronavirus_infections/InterimRevisedSurveillanceRecommendations_nCoVinfection_18May13.pdf ). – ident: r008 article-title: Clinical presentation and diagnosis. In: Hoffman C, Kamps S. SARS reference – 10/2003. 3rd ed. Flying Publisher, October 2003 ( http://www.SARSreference.com ). – ident: r002 article-title: ProMED. MERS-CoV–Eastern Mediterranean (06) ( http://www.promedmail.org/ ). – volume: 33 start-page: 1265 year: 2012 end-page: 1269 ident: r007 article-title: Recovery from severe novel coronavirus infection. publication-title: Saudi Med J – ident: r003 article-title: Genetic sequence information for scientists about the novel coronavirus 2012. London: Health Protection Agency, 2012 ( http://www.hpa.org.uk/Topics/InfectiousDiseases/InfectionsAZ/NovelCoronavirus/respPartialgeneticsequenceofnovelcoronavirus/ ). – volume: 361 start-page: 1767 year: 2003 end-page: 1772 ident: r006 article-title: Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study. publication-title: Lancet – ident: r005 article-title: Corman VM, Eckerle I, Bleicker T, et al. Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction. Euro Surveill 2012;17. – volume: 326 start-page: 1358 year: 2003 end-page: 1362 ident: r009 article-title: Haematological manifestations in patients with severe acute respiratory syndrome: retrospective analysis. publication-title: BMJ – ident: r004 article-title: World Health Organization. WHO final summary: SARS. August 15, 2003 ( http://www.who.int/csr/sars/country/2003_08_15/en/index.html ). – ident: r011 article-title: Zumla A, Gant V, Bates M, Mwaba P, Memish ZA. Rapid diagnostic urgently needed for killer infections. Lancet Resp Med 2013 May 20 [Epub ahead of print]. – ident: r009 doi: 10.1136/bmj.326.7403.1358 – volume: 33 start-page: 1265 year: 2012 ident: r007 publication-title: Saudi Med J – ident: r001 doi: 10.1056/NEJMoa1211721 – ident: r006 doi: 10.1016/S0140-6736(03)13412-5 – reference: - N Engl J Med. 2013 Aug 8;369(6):587 |
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| Snippet | A novel coronavirus (MERS-CoV) was recently identified as the cause of severe respiratory disease. In this report from Saudi Arabia, a family cluster of... A human coronavirus, called the Middle East respiratory syndrome coronavirus (MERS-CoV), was first identified in September 2012 in samples obtained from a... |
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| SubjectTerms | Adolescent Adult Aged Antibiotics Biological and medical sciences Communicable Diseases, Emerging - virology Coronaviridae Coronavirus - classification Coronavirus - isolation & purification Coronavirus Infections - diagnostic imaging Coronavirus Infections - virology Coronaviruses Disease Progression Electrolytes Fatalities Fever General aspects Geriatrics Hospitalization Hospitals Humans Infections Laboratories Lung - diagnostic imaging Male Medical sciences Middle East Pain Patients Pneumonia, Viral - diagnostic imaging Pneumonia, Viral - virology Radiography Respiratory diseases Respiratory failure Reverse Transcriptase Polymerase Chain Reaction Saudi Arabia Surveillance |
| Title | Family Cluster of Middle East Respiratory Syndrome Coronavirus Infections |
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