Functional genomic screens with death rate analyses reveal mechanisms of drug action - Honeywell, Megan E.; Isidor, Marie S.; Harper, Nicholas W.; Fontana, Rachel E.; Birdsall, Gavin A.; Cruz-Gordillo, Peter; Porto, Sydney A.; Jerome, Madison; Fraser, Cameron S.; Sarosiek, Kristopher A.; Guertin, David A.; Spinelli, Jessica B.; et al. (Nature chemical biology, 2024)
Keywords: 631/67/1059; 631/80/82; 631/92/360; 631/92/609; 631/92/93; Antineoplastic Agents - pharmacology; Apoptosis; Apoptosis - drug effects; Apoptosis - genetics; Biochemical Engineering; Biochemistry; Bioorganic Chemistry; Cell Biology; Cell death; Cell Death - drug effects; Cell Death - genetics; Cell Line, Tumor; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Damage detection; Deoxyribonucleic acid; DNA; DNA damage; DNA Damage - drug effects; DNA fingerprinting; Effectiveness; Genes; Genetic analysis; Genetic diversity; Genomics - methods; Humans; Lethality; Mortality; p53 Protein; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism