Experimental Analysis of Tablet Properties for Discrete Element Modeling of an Active Coating Process

• Published in: AAPS PharmSciTech Vol. 14; no. 1; pp. 402 - 411
• Main Authors: Just, Sarah, Toschkoff, Gregor, Funke, Adrian, Djuric, Dejan, Scharrer, Georg, Khinast, Johannes, Knop, Klaus, Kleinebudde, Peter
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.03.2013
• Subjects: Biochemistry; Biomedical and Life Sciences; Biomedicine; Biotechnology; Chemistry, Pharmaceutical; Coatings; Dosage Forms; Gastrointestinal Tract - drug effects; Materials Testing; Pharmacology/Toxicology; Pharmacy; Research Article; Tablets; tablet mechanical properties; tablet coating; DEM simulation; active film coating; dynamic angle of repose

Coating of solid dosage forms is an important unit operation in the pharmaceutical industry. In recent years, numerical simulations of drug manufacturing processes have been gaining interest as process analytical technology tools. The discrete element method (DEM) in particular is suitable to model...