CNTN5-/+or EHMT2-/+human iPSC-derived neurons from individuals with autism develop hyperactive neuronal networks - Deneault, Eric; Faheem, Muhammad; White, Sean H; Rodrigues, Deivid C; Sun, Song; Wei, Wei; Piekna, Alina; Thompson, Tadeo; Howe, Jennifer L; Chalil, Leon; Kwan, Vickie; Walker, Susan; et al. (eLife, 2019)
Keywords: Adolescent; Adult; Autism; Autistic Disorder - physiopathology; Cells, Cultured; Child; Contactins - deficiency; Contactins - genetics; Contactins - metabolism; CRISPR; Electrophysiological Phenomena; Families & family life; Female; Genes; Genetics; Genetics and Genomics; Genomes; Genomics; Glutamatergic transmission; Heterozygote; Histocompatibility Antigens - genetics; Histocompatibility Antigens - metabolism; Histone-Lysine N-Methyltransferase - deficiency; Histone-Lysine N-Methyltransferase - genetics; Histone-Lysine N-Methyltransferase - metabolism; Humans; Hyperactivity; Immunoglobulins; Induced Pluripotent Stem Cells - physiology; iPSC; Kinesin - genetics; Kinesin - metabolism; Male; Medical research; Middle Aged; Models, Theoretical; Nerve Net - physiology; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Neural networks; Neural stem cells; Neurons - physiology; Neuroscience; NGN2-neurons; Patch-Clamp Techniques; Phenotypes; Pluripotency; Research Communication; Stem cells; Ubiquitin-Conjugating Enzymes - genetics; Ubiquitin-Conjugating Enzymes - metabolism; Young Adult; Zinc Finger Protein Gli3 - genetics; Zinc Finger Protein Gli3 - metabolism; Canada; United States--US; CRISPR; genetics; neuroscience; iPSC; genomics; human; NGN2-neurons; autism