Proton pump inhibitor use: systematic review of global trends and practices

• Published in: European journal of clinical pharmacology Vol. 79; no. 9; pp. 1159 - 1172
• Main Authors: Shanika, Lelwala Guruge Thushani, Reynolds, Andrew, Pattison, Sharon, Braund, Rhiannon
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2023; Springer Nature B.V
• Subjects: Adult; Biomedical and Life Sciences; Biomedicine; Catalysts; Female; Health Care Costs; Humans; Male; Pharmacology/Toxicology; Prescriptions; Proton pump inhibitors; Proton Pump Inhibitors - adverse effects; Review; Reviews; Systematic review; Upper Gastrointestinal Tract; Global use; Proton pump inhibitors; Systematic review; Dose; Long term

Purpose Proton pump inhibitors (PPIs) reduce acid secretion in the stomach and rank as one of the most widely used acid-suppressing medicines globally. While PPIs are safe in the short-term, emerging evidence shows risks associated with long-term use. Current evidence on global PPI use is scarce. Th...