Novel rat model of gaming disorder: assessment of social reward and sex differences in behavior and c-Fos brain activity

• Published in: Psychopharmacology Vol. 242; no. 5; pp. 1103 - 1122
• Main Authors: Casile, Antonino, Marraudino, Marilena, Bonaldo, Brigitta, Micioni Di Bonaventura, Maria Vittoria, Nasini, Sofia, Cifani, Carlo, Gotti, Stefano
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.05.2025; Springer Nature B.V
• Subjects: Addictions; Amygdala; Animal models; Animals; Behavior, Addictive; Behavior, Animal - physiology; Biomedical and Life Sciences; Biomedicine; Brain - metabolism; c-Fos protein; Disease Models, Animal; Female; Gender differences; Immunohistochemistry; Internet Addiction Disorder - metabolism; Internet Addiction Disorder - physiopathology; Internet Addiction Disorder - psychology; Male; Neurosciences; Nucleus accumbens; Original Investigation; Pharmacology/Toxicology; Phenotypes; Prefrontal cortex; Proto-Oncogene Proteins c-fos - metabolism; Psychiatry; Rats; Rats, Inbred WKY; Reward; Sex Characteristics; Sex differences; Sex Factors; Social Behavior; Social interactions; Stria terminalis; Video Games - psychology; Animal model; Social reward; Hyperactivity; Gaming disorder (GD); Mental disorder; c-Fos; Sexual difference; Loss control

Rationale In 2018, the International Classification of Diseases (ICD-11) classified Gaming Disorder (GD) as a mental disorder. GD mainly occurs among adolescents, who, after developing addiction, show psychopathological traits, such as social anxiety, depression, social isolation, and attention defi...