Estradiol accelerates liver regeneration through estrogen receptor α

• Published in: Clinical and experimental gastroenterology Vol. 12; pp. 331 - 336
• Main Authors: Tsugawa, Yoji, Natori, Michiya, Handa, Hiroshi, Imai, Takeshi
• Format: Journal Article
• Language: English
• Published: New Zealand Taylor & Francis Ltd 01.01.2019; Dove; Dove Medical Press
• Subjects: Adipocytes; Bile; Cell growth; Cytokines; Endoplasmic reticulum; estrogen receptor α (ERα); Estrogens; Gastroenterology; Geriatrics; Gerontology; Laboratories; Liver; liver regeneration; Medical research; Metabolism; Original Research; Oxidation; partial hepatectomy; Rodents; Variance analysis; United States > US; Japan; partial hepatectomy; estrogens; estrogen receptor α; ERα; liver regeneration

We previously demonstrated that liver resection triggers estradiol production, which, in turn, induces the proliferation of hepatocytes to promote liver regeneration in mice. In this study, we demonstrated estradiol-induced estrogen receptor alpha (ERα) expression. To further explore the role of ERα...