Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission - Fichna, J.; Poole, D. P.; Veldhuis, N.; MacEachern, S. J.; Saur, D; Zakrzewski, P. K.; Cygankiewicz, A. I.; Mokrowiecka, A.; Małecka-Panas, E.; Krajewska, W. M.; Liedtke, W.; Steinhoff, M. S.; et al. (Journal of molecular medicine (Berlin, Germany), 2015)
Keywords: Adult; Aged; Aged, 80 and over; Animals; Biomedical and Life Sciences; Biomedicine; Case-Control Studies; Colon - drug effects; Colon - physiology; Colon - physiopathology; Disease Models, Animal; Female; Gastrointestinal Motility - drug effects; Gastrointestinal Motility - genetics; Gene Expression; Guanylate Cyclase - metabolism; Human Genetics; Humans; Internal Medicine; Irritable Bowel Syndrome - drug therapy; Irritable Bowel Syndrome - genetics; Irritable Bowel Syndrome - metabolism; Irritable Bowel Syndrome - physiopathology; Leucine - analogs & derivatives; Leucine - pharmacology; Male; Mice; Mice, Knockout; Middle Aged; Models, Biological; Molecular Medicine; Muscle Contraction - drug effects; Muscle, Smooth - drug effects; Muscle, Smooth - metabolism; Myenteric Plexus - metabolism; Nitric Oxide - metabolism; Nitric Oxide Synthase - metabolism; Original Article; Sulfonamides - pharmacology; Synaptic Transmission - genetics; TRPV Cation Channels - antagonists & inhibitors; TRPV Cation Channels - genetics; TRPV Cation Channels - metabolism; Myenteric plexus; Nitric oxide synthase type 1; Irritable bowel syndrome