A combination nutritional supplement reduces DNA methylation age only in older adults with a raised epigenetic age

• Published in: GeroScience Vol. 46; no. 5; pp. 4333 - 4347
• Main Authors: McGee, Kirsty C., Sullivan, Jack, Hazeldine, Jon, Schmunk, Lisa J., Martin-Herranz, Daniel E., Jackson, Thomas, Lord, Janet M.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.10.2024; Springer Nature B.V
• Subjects: Age; Aged; Aging; Aging - genetics; Ascorbic acid; Astaxanthin; Biomarkers; Biomarkers - blood; Biomarkers - metabolism; Biomedical and Life Sciences; Blood; C-reactive protein; C-Reactive Protein - metabolism; Cardiovascular diseases; Cell Biology; Clocks & watches; Dietary Supplements; DNA Methylation; Epigenesis, Genetic; Epigenetics; Female; Fish oils; Geriatrics/Gerontology; Growth Differentiation Factor 15 - genetics; Humans; Inflammation; Inflammation - genetics; Life Sciences; Male; Molecular Medicine; Older people; Original; Original Article; Resveratrol; Saliva; Saliva - chemistry; Saliva - metabolism; Vitamin D; DNA methylation; Inflammaging; Inflammation; Epigenetic clocks; Nutritional supplement

An increase in systemic inflammation (inflammaging) is one of the hallmarks of aging. Epigenetic (DNA methylation) clocks can quantify the degree of biological aging and this can be reversed by lifestyle and pharmacological intervention. We aimed to investigate whether a multi-component nutritional...