Escherichia coli non-coding regulatory regions are highly conserved

• Published in: NAR genomics and bioinformatics Vol. 6; no. 2; p. lqae041
• Main Authors: Lamoureux, Cameron R, Phaneuf, Patrick V, Palsson, Bernhard O, Zielinski, Daniel C
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.06.2024
• Subjects: Alleles; Amino acid substitution; Binding sites; Conserved sequence; E coli; Editor's Choice; Escherichia coli; Evolutionary conservation; Evolutionary genetics; Nucleotide sequence; Regulatory sequences; Transcription factors; Variation
• ISSN: 2631-9268; 2631-9268
• DOI: 10.1093/nargab/lqae041

Microbial genome sequences are rapidly accumulating, enabling large-scale studies of sequence variation. Existing studies primarily focus on coding regions to study amino acid substitution patterns in proteins. However, non-coding regulatory regions also play a distinct role in determining physiolog...