Fan-Shaped Body Neurons Are Involved in "Period"-Dependent Regulation of Long-Term Courtship Memory in "Drosophila"

In addition to its established function in the regulation of circadian rhythms, the "Drosophila" gene "period" ("per") also plays an important role in processing long-term memory (LTM). Here, we used courtship conditioning as a learning paradigm and revealed that (1) ov...

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Published inLearning & memory (Cold Spring Harbor, N.Y.) Vol. 19; no. 12; pp. 571 - 574
Main Authors Sakai, Takaomi, Inami, Show, Sato, Shoma, Kitamoto, Toshihiro
Format Journal Article
LanguageEnglish
Published United States Cold Spring Harbor Laboratory Press 01.12.2012
Subjects
Animals
Animals, Genetically Modified
Brain
Brief Communication
Conditioning
Courtship
Drosophila
Drosophila Proteins - genetics
Drosophila Proteins - metabolism
Entomology
Female
Gene Expression Regulation - genetics
Genetics
Green Fluorescent Proteins - genetics
Green Fluorescent Proteins - metabolism
Long Term Memory
Male
Memory, Long-Term - physiology
Mushroom Bodies - cytology
Neurology
Neurons - physiology
Period Circadian Proteins - genetics
Period Circadian Proteins - metabolism
Sleep
Sleep - genetics
Synaptic Transmission - genetics
Time Factors
Transcription Factors - metabolism
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Abstract In addition to its established function in the regulation of circadian rhythms, the "Drosophila" gene "period" ("per") also plays an important role in processing long-term memory (LTM). Here, we used courtship conditioning as a learning paradigm and revealed that (1) overexpression and knocking down of "per" in subsets of brain neurons enhance and suppress LTM, respectively, and (2) suppression of synaptic transmission during memory retrieval in the same neuronal subsets leads to defective LTM. Further analysis strongly suggests that the brain region critical for "per"-dependent LTM regulation is the fan-shaped body, which is involved in sleep-induced enhancement of courtship LTM.
AbstractList In addition to its established function in the regulation of circadian rhythms, the Drosophila gene period ( per ) also plays an important role in processing long-term memory (LTM). Here, we used courtship conditioning as a learning paradigm and revealed that (1) overexpression and knocking down of per in subsets of brain neurons enhance and suppress LTM, respectively, and (2) suppression of synaptic transmission during memory retrieval in the same neuronal subsets leads to defective LTM. Further analysis strongly suggests that the brain region critical for per -dependent LTM regulation is the fan-shaped body, which is involved in sleep-induced enhancement of courtship LTM.
In addition to its established function in the regulation of circadian rhythms, the Drosophila gene period (per) also plays an important role in processing long-term memory (LTM). Here, we used courtship conditioning as a learning paradigm and revealed that (1) overexpression and knocking down of per in subsets of brain neurons enhance and suppress LTM, respectively, and (2) suppression of synaptic transmission during memory retrieval in the same neuronal subsets leads to defective LTM. Further analysis strongly suggests that the brain region critical for per-dependent LTM regulation is the fan-shaped body, which is involved in sleep-induced enhancement of courtship LTM.
Author Kitamoto, Toshihiro
Inami, Show
Sakai, Takaomi
Sato, Shoma
AuthorAffiliation 2 Department of Anesthesia, University of Iowa, Iowa City, Iowa 52242, USA
1 Department of Biological Sciences, Tokyo Metropolitan University, Tokyo 192-0397, Japan
3 Interdisciplinary Graduate Programs in Genetics and Neuroscience, University of Iowa, Iowa City, Iowa 52242, USA
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Snippet In addition to its established function in the regulation of circadian rhythms, the "Drosophila" gene "period" ("per") also plays an important role in...
In addition to its established function in the regulation of circadian rhythms, the Drosophila gene period (per) also plays an important role in processing...
In addition to its established function in the regulation of circadian rhythms, the Drosophila gene period ( per ) also plays an important role in processing...
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SubjectTerms Animals
Animals, Genetically Modified
Brain
Brief Communication
Conditioning
Courtship
Drosophila
Drosophila Proteins - genetics
Drosophila Proteins - metabolism
Entomology
Female
Gene Expression Regulation - genetics
Genetics
Green Fluorescent Proteins - genetics
Green Fluorescent Proteins - metabolism
Long Term Memory
Male
Memory, Long-Term - physiology
Mushroom Bodies - cytology
Neurology
Neurons - physiology
Period Circadian Proteins - genetics
Period Circadian Proteins - metabolism
Sleep
Sleep - genetics
Synaptic Transmission - genetics
Time Factors
Transcription Factors - metabolism
Title Fan-Shaped Body Neurons Are Involved in "Period"-Dependent Regulation of Long-Term Courtship Memory in "Drosophila"
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