(R)-Ketamine Induces a Greater Increase in Prefrontal 5-HT Release Than (S)-Ketamine and Ketamine Metabolites via an AMPA Receptor-Independent Mechanism

• Published in: The international journal of neuropsychopharmacology Vol. 22; no. 10; pp. 665 - 674
• Main Authors: Ago, Yukio, Tanabe, Wataru, Higuchi, Momoko, Tsukada, Shinji, Tanaka, Tatsunori, Yamaguchi, Takumi, Igarashi, Hisato, Yokoyama, Rei, Seiriki, Kaoru, Kasai, Atsushi, Nakazawa, Takanobu, Nakagawa, Shinsaku, Hashimoto, Kenji, Hashimoto, Hitoshi
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.10.2019
• Subjects: Animals; Disease Models, Animal; Dopamine; Dopamine - metabolism; Dose-Response Relationship, Drug; Ketamine; Ketamine - administration & dosage; Ketamine - analogs & derivatives; Ketamine - antagonists & inhibitors; Ketamine - pharmacology; Lipopolysaccharides; Male; Metabolites; Mice; Microdialysis; Microinjections; Norepinephrine - metabolism; Prefrontal Cortex - metabolism; Quinoxalines - pharmacology; Receptors, AMPA - metabolism; Regular; Serotonin; Serotonin - metabolism; Stereoisomerism; (S)-ketamine; AMPA receptors; (R)-ketamine; monoamine; prefrontal cortex

Although recent studies provide insight into the molecular mechanisms of the effects of ketamine, the antidepressant mechanism of ketamine enantiomers and their metabolites is not fully understood. In view of the involvement of mechanisms other than the N-methyl-D-aspartate receptor in ketamine'...