Sustained Tubulo-interstitial Protection in SHRs by Transient Losartan Treatment: An Effect of Decelerated Aging?

• Published in: American journal of hypertension Vol. 21; no. 2; pp. 177 - 182
• Main Authors: Baumann, Marcus, Bartholome, Roger, Peutz-Kootstra, Carine J., Smits, Jos F.M., Struijker-Boudier, Harry A.J.
• Format: Journal Article
• Language: English
• Published: New York, NY Oxford University Press 01.02.2008; Elsevier Science
• Subjects: Aging - physiology; Angiotensin II Type 1 Receptor Blockers - pharmacology; Animals; Antihypertensive agents; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Cardiovascular system; Cell Cycle - drug effects; Cell Division - drug effects; Hyperplasia; Hypertension, Renal - drug therapy; Hypertension, Renal - pathology; Hypertension, Renal - physiopathology; Kidney Tubules - drug effects; Kidney Tubules - pathology; Kidney Tubules - physiology; Losartan - pharmacology; Male; Medical sciences; Pharmacology. Drug treatments; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Hypertension; Imidazole derivatives; Tetrazole derivatives; Senescence; Peptide hormone; Non peptide compound; Cardiovascular disease; Octapeptide; Treatment; Biphenyl derivatives; Losartan; Antihypertensive agent; Sartan derivatives; Angiotensin antagonist; Angiotensin II

Background Hypertensive target organ damage shows characteristics of accelerated cell turnover and aging. This might have developed during the evolution of hypertension. In the kidney, high cell turnover is mainly restricted to tubular cells. It was the aim of this study to investigate whether a tra...