gutSMASH predicts specialized primary metabolic pathways from the human gut microbiota

• Published in: Nature biotechnology Vol. 41; no. 10; pp. 1416 - 1423
• Main Authors: Pascal Andreu, Victòria, Augustijn, Hannah E., Chen, Lianmin, Zhernakova, Alexandra, Fu, Jingyuan, Fischbach, Michael A., Dodd, Dylan, Medema, Marnix H.
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.10.2023; Nature Publishing Group
• Subjects: 631/114/2390; 631/326/2565/2134; 639/638/92/1643; 692/698/2741/2135; Acid production; Agriculture; Algorithms; Bacteria; Bioinformatics; Biomedical and Life Sciences; Biomedical Engineering/Biotechnology; Biomedicine; Biotechnology; Fatty acids; Feces - microbiology; Gastrointestinal Microbiome - genetics; Gene clusters; Gene regulation; Genes; Genomes; Gut microbiota; Humans; Intestinal microflora; Life Sciences; Markov chains; Metabolic Networks and Pathways - genetics; Metabolic pathways; Metabolism; Metabolites; Metagenomics; Microbiomes; Microbiota; Microorganisms; Secondary metabolites; Taxa

The gut microbiota produce hundreds of small molecules, many of which modulate host physiology. Although efforts have been made to identify biosynthetic genes for secondary metabolites, the chemical output of the gut microbiome consists predominantly of primary metabolites. Here we introduce the gut...