Native T1 Mapping in Transthyretin Amyloidosis

• Published in: JACC. Cardiovascular imaging Vol. 7; no. 2; pp. 157 - 165
• Main Authors: Fontana, Marianna, Banypersad, Sanjay M., Treibel, Thomas A., Maestrini, Viviana, Sado, Daniel M., White, Steven K., Pica, Silvia, Castelletti, Silvia, Piechnik, Stefan K., Robson, Matthew D., Gilbertson, Janet A., Rowczenio, Dorota, Hutt, David F., Lachmann, Helen J., Wechalekar, Ashutosh D., Whelan, Carol J., Gillmore, Julian D., Hawkins, Philip N., Moon, James C.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2014
• Subjects: amyloidosis; Amyloidosis - diagnosis; cardiac magnetic resonance; Cardiovascular; Female; Heart Diseases - diagnosis; Humans; Male; T1 mapping; transthyretin; AL amyloidosis; amyloidosis; RV; transthyretin; ECG; CMR; LV; LGE; ShMOLLI; T1 mapping; HCM; NT-proBNP; TTR; DPD; cardiac magnetic resonance; ATTR amyloidosis; LVH; right ventricle/ventricular; electrocardiogram; left ventricle/ventricular; immunoglobulin light-chain amyloidosis; 3,3-diphosphono-1,2-propanodicarboxylicacid; transthyretin protein; shortened modified look-locker inversion recovery; left ventricular hypertrophy; hypertrophic cardiomyopathy; late gadolinium enhancement; N-terminal pro-brain natriuretic peptide; transthyretin amyloidosis

The aims of the study were to explore the ability of native myocardial T1 mapping by cardiac magnetic resonance to: 1) detect cardiac involvement in patients with transthyretin amyloidosis (ATTR amyloidosis); 2) track the cardiac amyloid burden; and 3) detect early disease. ATTR amyloidosis is an un...