The Potential of Stimuli-Responsive Nanogels in Drug and Active Molecule Delivery for Targeted Therapy

Nanogels (NGs) are currently under extensive investigation due to their unique properties, such as small particle size, high encapsulation efficiency and protection of active agents from degradation, which make them ideal candidates as drug delivery systems (DDS). Stimuli-responsive NGs are cross-li...

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Published inGels Vol. 3; no. 2; p. 16
Main Authors Vicario-de-la-Torre, Marta, Forcada, Jacqueline
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 08.05.2017
MDPI
Subjects
Bioavailability
Biomedical materials
Brain research
Cancer therapies
Crosslinking
Diabetes
Drug delivery systems
Drugs
Electric field strength
Encapsulation
Gels
Glucose
Hydrogels
Ligands
Molecular structure
nanogels
Nanoparticles
Organic chemistry
Phase transitions
Polymers
Review
Stimuli
stimuli-responsive nanoparticles
Substrates
Tumors
Spain
drug delivery systems
nanogels
stimuli-responsive nanoparticles
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Abstract Nanogels (NGs) are currently under extensive investigation due to their unique properties, such as small particle size, high encapsulation efficiency and protection of active agents from degradation, which make them ideal candidates as drug delivery systems (DDS). Stimuli-responsive NGs are cross-linked nanoparticles (NPs), composed of polymers, natural, synthetic, or a combination thereof that can swell by absorption (uptake) of large amounts of solvent, but not dissolve due to the constituent structure of the polymeric network. NGs can undergo change from a polymeric solution (swell form) to a hard particle (collapsed form) in response to (i) physical stimuli such as temperature, ionic strength, magnetic or electric fields; (ii) chemical stimuli such as pH, ions, specific molecules or (iii) biochemical stimuli such as enzymatic substrates or affinity ligands. The interest in NGs comes from their multi-stimuli nature involving reversible phase transitions in response to changes in the external media in a faster way than macroscopic gels or hydrogels due to their nanometric size. NGs have a porous structure able to encapsulate small molecules such as drugs and genes, then releasing them by changing their volume when external stimuli are applied.
AbstractList Nanogels (NGs) are currently under extensive investigation due to their unique properties, such as small particle size, high encapsulation efficiency and protection of active agents from degradation, which make them ideal candidates as drug delivery systems (DDS). Stimuli-responsive NGs are cross-linked nanoparticles (NPs), composed of polymers, natural, synthetic, or a combination thereof that can swell by absorption (uptake) of large amounts of solvent, but not dissolve due to the constituent structure of the polymeric network. NGs can undergo change from a polymeric solution (swell form) to a hard particle (collapsed form) in response to (i) physical stimuli such as temperature, ionic strength, magnetic or electric fields; (ii) chemical stimuli such as pH, ions, specific molecules or (iii) biochemical stimuli such as enzymatic substrates or affinity ligands. The interest in NGs comes from their multi-stimuli nature involving reversible phase transitions in response to changes in the external media in a faster way than macroscopic gels or hydrogels due to their nanometric size. NGs have a porous structure able to encapsulate small molecules such as drugs and genes, then releasing them by changing their volume when external stimuli are applied.
Author Forcada, Jacqueline
Vicario-de-la-Torre, Marta
AuthorAffiliation 2 Bionanoparticles Group, Facultad de Ciencias Químicas, University of the Basque Country UPV/EHU, Donostia-San Sebastián 20018, Spain
1 Nutra Essential OTC, Alcobendas, Madrid 28108, Spain; martavicario@nutraessential.com
AuthorAffiliation_xml – name: 2 Bionanoparticles Group, Facultad de Ciencias Químicas, University of the Basque Country UPV/EHU, Donostia-San Sebastián 20018, Spain
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  givenname: Jacqueline
  surname: Forcada
  fullname: Forcada, Jacqueline
  email: jacqueline.forcada@ehu.es
  organization: Bionanoparticles Group, Facultad de Ciencias Químicas, University of the Basque Country UPV/EHU, Donostia-San Sebastián 20018, Spain. jacqueline.forcada@ehu.es
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30920515$$D View this record in MEDLINE/PubMed
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Issue 2
Keywords drug delivery systems
nanogels
stimuli-responsive nanoparticles
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Snippet Nanogels (NGs) are currently under extensive investigation due to their unique properties, such as small particle size, high encapsulation efficiency and...
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SubjectTerms Bioavailability
Biomedical materials
Brain research
Cancer therapies
Crosslinking
Diabetes
Drug delivery systems
Drugs
Electric field strength
Encapsulation
Gels
Glucose
Hydrogels
Ligands
Molecular structure
nanogels
Nanoparticles
Organic chemistry
Phase transitions
Polymers
Review
Stimuli
stimuli-responsive nanoparticles
Substrates
Tumors
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Title The Potential of Stimuli-Responsive Nanogels in Drug and Active Molecule Delivery for Targeted Therapy
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