EcDBS1R6: A novel cationic antimicrobial peptide derived from a signal peptide sequence

• Published in: Biochimica et biophysica acta. General subjects Vol. 1864; no. 9; p. 129633
• Main Authors: Porto, William F., Irazazabal, Luz N., Humblot, Vincent, Haney, Evan F., Ribeiro, Suzana M., Hancock, Robert E.W., Ladram, Ali, Franco, Octavio L.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2020; Elsevier
• Subjects: Amino Acid Sequence; Antimicrobial Cationic Peptides - chemistry; Antimicrobial Cationic Peptides - pharmacology; antimicrobial peptides; antimicrobial properties; bacteria; bacterial infections; Escherichia coli; Escherichia coli - chemistry; fluorescent dyes; Gram-Negative Bacteria - drug effects; image analysis; Joker algorithm; Life Sciences; Mechanism of action; Membrane damage; Microbial Sensitivity Tests; minimum inhibitory concentration; molecular dynamics; Molecular Dynamics Simulation; Protein Conformation; Protein Sorting Signals; Rational design; scanning electron microscopy; signal peptide; Sliding window; Rational design; Mechanism of action; Joker algorithm; Membrane damage; Sliding window

Bacterial infections represent a major worldwide health problem the antimicrobial peptides (AMPs) have been considered as potential alternative agents for treating these infections. Here we demonstrated the antimicrobial activity of EcDBS1R6, a peptide derived from a signal peptide sequence of Esche...