ETV6::ACSL6 translocation-driven super-enhancer activation leads to eosinophilia in acute lymphoblastic leukemia through IL-3 overexpression - Xu, Wenqian; Tian, Feng; Tai, Xiaolu; Song, Gaoxian; Liu, Yuanfang; Fan, Liquan; Weng, Xiangqin; Yang, Eunjeong; Wang, Meng; Bornhäuser, Martin; Zhang, Chao; Lock, Richard B.; et al. (Haematologica (Roma), 2024)
Keywords: Acute Lymphoblastic Leukemia; Animals; Enhancer Elements, Genetic; Eosinophilia - genetics; Eosinophilia - metabolism; Eosinophilia - pathology; ETS Translocation Variant 6 Protein; Gene Expression Regulation, Leukemic; Humans; Interleukin-3 - genetics; Interleukin-3 - metabolism; Mice; Oncogene Proteins, Fusion - genetics; Oncogene Proteins, Fusion - metabolism; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism; Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology; Proto-Oncogene Proteins c-ets - genetics; Proto-Oncogene Proteins c-ets - metabolism; Repressor Proteins - genetics; Repressor Proteins - metabolism; Translocation, Genetic