Stiff matrix induces exosome secretion to promote tumour growth

• Published in: Nature cell biology Vol. 25; no. 3; pp. 415 - 424
• Main Authors: Wu, Bin, Liu, Di-Ao, Guan, Lei, Myint, Phyoe Kyawe, Chin, LiKang, Dang, Hien, Xu, Ye, Ren, Jinqi, Li, Ting, Yu, Ziyan, Jabban, Sophie, Mills, Gordon B., Nukpezah, Jonathan, Chen, Youhai H., Furth, Emma E., Gimotty, Phyllis A., Wells, Rebecca G., Weaver, Valerie M., Radhakrishnan, Ravi, Wang, Xin Wei, Guo, Wei
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2023; Nature Publishing Group
• Subjects: 13/51; 13/95; 14/19; 14/5; 38/79; 45/70; 631/67/327; 631/80/313/2376; 64/60; 82/29; 82/80; AKT protein; Biomedical and Life Sciences; Cancer; Cancer Research; Cell Biology; Developmental Biology; Exosomes; Exosomes - metabolism; Extracellular matrix; Extracellular Matrix - metabolism; Fibrosis; Gene expression; Humans; Life Sciences; Mechanical properties; Microenvironments; Neoplasms - metabolism; Proteomics; Secretion; Signal Transduction; Stem Cells; Stiffening; Stiffness; Tumor Microenvironment; Tumors

Tissue fibrosis and extracellular matrix (ECM) stiffening promote tumour progression. The mechanisms by which ECM regulates its contacting cells have been extensively studied. However, how stiffness influences intercellular communications in the microenvironment for tumour progression remains unknow...