Isolation and Differentiation of Neurons and Glial Cells from Olfactory Epithelium in Living Subjects

The study of psychiatric and neurological diseases requires the substrate in which the disorders occur, that is, the nervous tissue. Currently, several types of human bio-specimens are being used for research, including postmortem brains, cerebrospinal fluid, induced pluripotent stem (iPS) cells, an...

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Published inMolecular neurobiology Vol. 60; no. 8; pp. 4472 - 4487
Main Authors Unzueta-Larrinaga, Paula, Barrena-Barbadillo, Rocío, Ibarra-Lecue, Inés, Horrillo, Igor, Villate, Aitor, Recio, Maria, Meana, J. Javier, Diez-Alarcia, Rebeca, Mentxaka, Oihane, Segarra, Rafael, Etxebarria, Nestor, Callado, Luis F., Urigüen, Leyre
Format Journal Article
LanguageEnglish
Published New York Springer US 01.08.2023
Springer Nature B.V
Subjects
Basement Membrane - cytology
Biomarkers - analysis
Biomedical and Life Sciences
Biomedicine
Brain research
Cell Adhesion
Cell Biology
Cell culture
Cell Culture Techniques - methods
Cell Differentiation
Cell Proliferation
Cell Separation - methods
Cells, Cultured
Cerebrospinal fluid
Culture Media - chemistry
Flow Cytometry
Glial cells
Humans
Immunohistochemistry
Magnetics
Mental disorders
Neural Stem Cells - cytology
Neurobiology
Neurogenesis
Neuroglia - cytology
Neurological diseases
Neurology
Neuronal-glial interactions
Neurons - cytology
Neurosciences
Neurospheres
Olfactory epithelium
Olfactory Mucosa - cytology
Olfactory receptor neurons
Organ Specificity
Original
Original Article
Pluripotency
Sensory neurons
Stem cells
Olfactory epithelium
Glia
PSA-NCAM
Neurons
Neurospheres
Neuropsychiatric diseases
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Abstract The study of psychiatric and neurological diseases requires the substrate in which the disorders occur, that is, the nervous tissue. Currently, several types of human bio-specimens are being used for research, including postmortem brains, cerebrospinal fluid, induced pluripotent stem (iPS) cells, and induced neuronal (iN) cells. However, these samples are far from providing a useful predictive, diagnostic, or prognostic biomarker. The olfactory epithelium is a region close to the brain that has received increased interest as a research tool for the study of brain mechanisms in complex neuropsychiatric and neurological diseases. The olfactory sensory neurons are replaced by neurogenesis throughout adult life from stem cells on the basement membrane. These stem cells are multipotent and can be propagated in neurospheres, proliferated in vitro and differentiated into multiple cell types including neurons and glia. For all these reasons, olfactory epithelium provides a unique resource for investigating neuronal molecular markers of neuropsychiatric and neurological diseases. Here, we describe the isolation and culture of human differentiated neurons and glial cells from olfactory epithelium of living subjects by an easy and non-invasive exfoliation method that may serve as a useful tool for the research in brain diseases.
AbstractList The study of psychiatric and neurological diseases requires the substrate in which the disorders occur, that is, the nervous tissue. Currently, several types of human bio-specimens are being used for research, including postmortem brains, cerebrospinal fluid, induced pluripotent stem (iPS) cells, and induced neuronal (iN) cells. However, these samples are far from providing a useful predictive, diagnostic, or prognostic biomarker. The olfactory epithelium is a region close to the brain that has received increased interest as a research tool for the study of brain mechanisms in complex neuropsychiatric and neurological diseases. The olfactory sensory neurons are replaced by neurogenesis throughout adult life from stem cells on the basement membrane. These stem cells are multipotent and can be propagated in neurospheres, proliferated in vitro and differentiated into multiple cell types including neurons and glia. For all these reasons, olfactory epithelium provides a unique resource for investigating neuronal molecular markers of neuropsychiatric and neurological diseases. Here, we describe the isolation and culture of human differentiated neurons and glial cells from olfactory epithelium of living subjects by an easy and non-invasive exfoliation method that may serve as a useful tool for the research in brain diseases.The study of psychiatric and neurological diseases requires the substrate in which the disorders occur, that is, the nervous tissue. Currently, several types of human bio-specimens are being used for research, including postmortem brains, cerebrospinal fluid, induced pluripotent stem (iPS) cells, and induced neuronal (iN) cells. However, these samples are far from providing a useful predictive, diagnostic, or prognostic biomarker. The olfactory epithelium is a region close to the brain that has received increased interest as a research tool for the study of brain mechanisms in complex neuropsychiatric and neurological diseases. The olfactory sensory neurons are replaced by neurogenesis throughout adult life from stem cells on the basement membrane. These stem cells are multipotent and can be propagated in neurospheres, proliferated in vitro and differentiated into multiple cell types including neurons and glia. For all these reasons, olfactory epithelium provides a unique resource for investigating neuronal molecular markers of neuropsychiatric and neurological diseases. Here, we describe the isolation and culture of human differentiated neurons and glial cells from olfactory epithelium of living subjects by an easy and non-invasive exfoliation method that may serve as a useful tool for the research in brain diseases.
The study of psychiatric and neurological diseases requires the substrate in which the disorders occur, that is, the nervous tissue. Currently, several types of human bio-specimens are being used for research, including postmortem brains, cerebrospinal fluid, induced pluripotent stem (iPS) cells, and induced neuronal (iN) cells. However, these samples are far from providing a useful predictive, diagnostic, or prognostic biomarker. The olfactory epithelium is a region close to the brain that has received increased interest as a research tool for the study of brain mechanisms in complex neuropsychiatric and neurological diseases. The olfactory sensory neurons are replaced by neurogenesis throughout adult life from stem cells on the basement membrane. These stem cells are multipotent and can be propagated in neurospheres, proliferated in vitro and differentiated into multiple cell types including neurons and glia. For all these reasons, olfactory epithelium provides a unique resource for investigating neuronal molecular markers of neuropsychiatric and neurological diseases. Here, we describe the isolation and culture of human differentiated neurons and glial cells from olfactory epithelium of living subjects by an easy and non-invasive exfoliation method that may serve as a useful tool for the research in brain diseases.
Author Urigüen, Leyre
Etxebarria, Nestor
Barrena-Barbadillo, Rocío
Ibarra-Lecue, Inés
Diez-Alarcia, Rebeca
Horrillo, Igor
Meana, J. Javier
Segarra, Rafael
Villate, Aitor
Mentxaka, Oihane
Recio, Maria
Callado, Luis F.
Unzueta-Larrinaga, Paula
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/37118325$$D View this record in MEDLINE/PubMed
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CitedBy_id crossref_primary_10_17116_jnevro202412412120
crossref_primary_10_1080_15622975_2024_2357096
crossref_primary_10_3389_fpsyt_2024_1283406
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1559-1182
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Issue 8
Keywords Olfactory epithelium
Glia
PSA-NCAM
Neurons
Neurospheres
Neuropsychiatric diseases
Language English
License 2023. The Author(s).
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Snippet The study of psychiatric and neurological diseases requires the substrate in which the disorders occur, that is, the nervous tissue. Currently, several types...
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SubjectTerms Basement Membrane - cytology
Biomarkers - analysis
Biomedical and Life Sciences
Biomedicine
Brain research
Cell Adhesion
Cell Biology
Cell culture
Cell Culture Techniques - methods
Cell Differentiation
Cell Proliferation
Cell Separation - methods
Cells, Cultured
Cerebrospinal fluid
Culture Media - chemistry
Flow Cytometry
Glial cells
Humans
Immunohistochemistry
Magnetics
Mental disorders
Neural Stem Cells - cytology
Neurobiology
Neurogenesis
Neuroglia - cytology
Neurological diseases
Neurology
Neuronal-glial interactions
Neurons - cytology
Neurosciences
Neurospheres
Olfactory epithelium
Olfactory Mucosa - cytology
Olfactory receptor neurons
Organ Specificity
Original
Original Article
Pluripotency
Sensory neurons
Stem cells
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Title Isolation and Differentiation of Neurons and Glial Cells from Olfactory Epithelium in Living Subjects
URI https://link.springer.com/article/10.1007/s12035-023-03363-2
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Volume 60
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