Neurofilament light chain in spinal fluid and plasma in multiple system atrophy: a prospective, longitudinal biomarker study

• Published in: Clinical autonomic research Vol. 33; no. 6; pp. 635 - 645
• Main Authors: Singer, Wolfgang, Schmeichel, Ann M., Sletten, David M., Gehrking, Tonette L., Gehrking, Jade A., Trejo-Lopez, Jorge, Suarez, Mariana D., Anderson, Jennifer K., Bass, Pamela H., Lesnick, Timothy G., Low, Phillip A.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2023; Springer Nature B.V
• Subjects: Aged; Atrophy; Biomarkers; Biomarkers - blood; Biomarkers - cerebrospinal fluid; Cardiology; Cerebrospinal fluid; Diabetes; Endocrinology; Female; Gastroenterology; Humans; Immunoassay; Longitudinal Studies; Male; Medicine; Medicine & Public Health; Middle Aged; Movement disorders; Multiple System Atrophy - blood; Multiple System Atrophy - cerebrospinal fluid; Neurodegenerative diseases; Neurofilament Proteins - blood; Neurofilament Proteins - cerebrospinal fluid; Neurology; Ophthalmology; Parkinson Disease - blood; Parkinson Disease - cerebrospinal fluid; Parkinson's disease; Reproducibility of Results; Research Article; Multiple system atrophy; Neurofilament light chain; Biomarker; Parkinson’s disease

Purpose There is a critical need for reliable diagnostic biomarkers as well as surrogate markers of disease progression in multiple system atrophy (MSA). Neurofilament light chain (NfL) has been reported to potentially meet those needs. We therefore sought to explore the value of NfL in plasma (NfL-...