Circulating Levels of Interleukin-35 in Patients with Multiple Sclerosis: Evaluation of the Influences of FOXP3 Gene Polymorphism and Treatment Program

• Published in: Journal of molecular neuroscience Vol. 55; no. 4; pp. 891 - 897
• Main Authors: Jafarzadeh, A., Jamali, M., Mahdavi, R., Ebrahimi, H. A., Hajghani, H., Khosravimashizi, A., Nemati, M., Najafipour, H., Sheikhi, A., Mohammadi, M. M., Daneshvar, H.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.04.2015; Springer Nature B.V
• Subjects: Adult; Autoimmune diseases; Biomedical and Life Sciences; Biomedicine; Case-Control Studies; Cell Biology; Cytokines; Disease; Female; Forkhead Transcription Factors - genetics; Genotype & phenotype; Humans; Immunology; Interferon-beta - therapeutic use; Interleukins - blood; Male; Methylprednisolone - therapeutic use; Middle Aged; Multiple sclerosis; Multiple Sclerosis - blood; Multiple Sclerosis - drug therapy; Multiple Sclerosis - genetics; Neurochemistry; Neurology; Neurosciences; Pathogenesis; Polymorphism; Polymorphism, Single Nucleotide; Proteomics; Iran; Multiple sclerosis; Treatment; IL-35; FOXP3; Gene polymorphism
• ISSN: 0895-8696; 1559-1166; 1559-1166
• DOI: 10.1007/s12031-014-0443-z

The regulatory T (Treg) cells play a major role in the control of the autoimmunity and inflammation, and IL-35 has been described as an immunosuppressive cytokine that is mainly produced by CD4 + FOXP3 + Treg cells. The aim of this study was to evaluate the serum levels of IL-35 and a single nucleot...