HIF-dependent and reversible nucleosome disassembly in hypoxia-inducible gene promoters
Hypoxia causes dramatic changes in gene expression profiles, and the mechanism of hypoxia-inducible transcription has been analyzed for use as a model system of stress-inducible gene regulation. In this study, changes in chromatin organization in promoters of hypoxia-inducible genes were investigate...
Saved in:
| Published in | Experimental cell research Vol. 366; no. 2; pp. 181 - 191 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
15.05.2018
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Hypoxia causes dramatic changes in gene expression profiles, and the mechanism of hypoxia-inducible transcription has been analyzed for use as a model system of stress-inducible gene regulation. In this study, changes in chromatin organization in promoters of hypoxia-inducible genes were investigated during hypoxia-reoxygenation conditions. Most of the hypoxia-inducible gene promoters were hypersensitive to DNase I under both normal and hypoxic conditions, and our data indicate an immediate recruitment of transcription factors under hypoxic conditions. In some of the hypoxia-inducible promoters, nucleosome-free DNA regions (NFRs) were established in parallel with hypoxia-induced transcription. We also show that the hypoxia-inducible formation of NFRs requires that hypoxia-inducible transcription factors (HIFs) bind to the promoters together with the transcriptional coactivator CBP. Within 1 h after the hypoxia exposure was ended (reoxygenation), HIF complexes were dissociated from the promoter regions. Within 24 h of reoxygenation, the hypoxia-induced transcription returned to basal levels and the nucleosome structure was reassembled in the hypoxia-inducible NFRs. Nucleosome reassembly required the function of the transcriptional coregulator SIN3A. Thus, reversible changes in nucleosome organization mediated by transcription factors are notable features of stress-inducible gene regulation.
[Display omitted]
•Nucleosome-free regions (NFRs) are established in some gene promoters in a hypoxia-dependent manner.•Hypoxia-inducible NFR (iNFR) formation requires hypoxia-inducible transcription factor (HIF) activity.•Reoxygenation induces the reassembly of nucleosome structures in iNFRs.•Nucleosome reassembly in iNFRs requires SIN3A. |
|---|---|
| AbstractList | Highlights: • Nucleosome-free regions (NFRs) are established in some gene promoters in a hypoxia-dependent manner. • Hypoxia-inducible NFR (iNFR) formation requires hypoxia-inducible transcription factor (HIF) activity. • Reoxygenation induces the reassembly of nucleosome structures in iNFRs. • Nucleosome reassembly in iNFRs requires SIN3A. Hypoxia causes dramatic changes in gene expression profiles, and the mechanism of hypoxia-inducible transcription has been analyzed for use as a model system of stress-inducible gene regulation. In this study, changes in chromatin organization in promoters of hypoxia-inducible genes were investigated during hypoxia-reoxygenation conditions. Most of the hypoxia-inducible gene promoters were hypersensitive to DNase I under both normal and hypoxic conditions, and our data indicate an immediate recruitment of transcription factors under hypoxic conditions. In some of the hypoxia-inducible promoters, nucleosome-free DNA regions (NFRs) were established in parallel with hypoxia-induced transcription. We also show that the hypoxia-inducible formation of NFRs requires that hypoxia-inducible transcription factors (HIFs) bind to the promoters together with the transcriptional coactivator CBP. Within 1 h after the hypoxia exposure was ended (reoxygenation), HIF complexes were dissociated from the promoter regions. Within 24 h of reoxygenation, the hypoxia-induced transcription returned to basal levels and the nucleosome structure was reassembled in the hypoxia-inducible NFRs. Nucleosome reassembly required the function of the transcriptional coregulator SIN3A. Thus, reversible changes in nucleosome organization mediated by transcription factors are notable features of stress-inducible gene regulation. Hypoxia causes dramatic changes in gene expression profiles, and the mechanism of hypoxia-inducible transcription has been analyzed for use as a model system of stress-inducible gene regulation. In this study, changes in chromatin organization in promoters of hypoxia-inducible genes were investigated during hypoxia-reoxygenation conditions. Most of the hypoxia-inducible gene promoters were hypersensitive to DNase I under both normal and hypoxic conditions, and our data indicate an immediate recruitment of transcription factors under hypoxic conditions. In some of the hypoxia-inducible promoters, nucleosome-free DNA regions (NFRs) were established in parallel with hypoxia-induced transcription. We also show that the hypoxia-inducible formation of NFRs requires that hypoxia-inducible transcription factors (HIFs) bind to the promoters together with the transcriptional coactivator CBP. Within 1 h after the hypoxia exposure was ended (reoxygenation), HIF complexes were dissociated from the promoter regions. Within 24 h of reoxygenation, the hypoxia-induced transcription returned to basal levels and the nucleosome structure was reassembled in the hypoxia-inducible NFRs. Nucleosome reassembly required the function of the transcriptional coregulator SIN3A. Thus, reversible changes in nucleosome organization mediated by transcription factors are notable features of stress-inducible gene regulation. Hypoxia causes dramatic changes in gene expression profiles, and the mechanism of hypoxia-inducible transcription has been analyzed for use as a model system of stress-inducible gene regulation. In this study, changes in chromatin organization in promoters of hypoxia-inducible genes were investigated during hypoxia-reoxygenation conditions. Most of the hypoxia-inducible gene promoters were hypersensitive to DNase I under both normal and hypoxic conditions, and our data indicate an immediate recruitment of transcription factors under hypoxic conditions. In some of the hypoxia-inducible promoters, nucleosome-free DNA regions (NFRs) were established in parallel with hypoxia-induced transcription. We also show that the hypoxia-inducible formation of NFRs requires that hypoxia-inducible transcription factors (HIFs) bind to the promoters together with the transcriptional coactivator CBP. Within 1 h after the hypoxia exposure was ended (reoxygenation), HIF complexes were dissociated from the promoter regions. Within 24 h of reoxygenation, the hypoxia-induced transcription returned to basal levels and the nucleosome structure was reassembled in the hypoxia-inducible NFRs. Nucleosome reassembly required the function of the transcriptional coregulator SIN3A. Thus, reversible changes in nucleosome organization mediated by transcription factors are notable features of stress-inducible gene regulation. [Display omitted] •Nucleosome-free regions (NFRs) are established in some gene promoters in a hypoxia-dependent manner.•Hypoxia-inducible NFR (iNFR) formation requires hypoxia-inducible transcription factor (HIF) activity.•Reoxygenation induces the reassembly of nucleosome structures in iNFRs.•Nucleosome reassembly in iNFRs requires SIN3A. |
| Author | Yang, Henry Vojnovic, Nikola Suzuki, Norio Poellinger, Lorenz Gradin, Katarina Lee, Kian-Leong |
| Author_xml | – sequence: 1 givenname: Norio surname: Suzuki fullname: Suzuki, Norio email: sunorio@med.tohoku.ac.jp organization: Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden – sequence: 2 givenname: Nikola surname: Vojnovic fullname: Vojnovic, Nikola organization: Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden – sequence: 3 givenname: Kian-Leong surname: Lee fullname: Lee, Kian-Leong organization: Cancer Science Institute of Singapore, National University of Singapore, Singapore, Republic of Singapore – sequence: 4 givenname: Henry surname: Yang fullname: Yang, Henry organization: Cancer Science Institute of Singapore, National University of Singapore, Singapore, Republic of Singapore – sequence: 5 givenname: Katarina surname: Gradin fullname: Gradin, Katarina organization: Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden – sequence: 6 givenname: Lorenz surname: Poellinger fullname: Poellinger, Lorenz organization: Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29574021$$D View this record in MEDLINE/PubMed https://www.osti.gov/biblio/23082385$$D View this record in Osti.gov http://kipublications.ki.se/Default.aspx?queryparsed=id:138038757$$DView record from Swedish Publication Index |
| BookMark | eNp9kU1v1DAQhi1URLeFX4CEInHhkjC2k9g5cEAV_ZAqcQFxtBx7lnpJ7MVOSvff491s2xOcbI2fZ2bk94yc-OCRkLcUKgq0_bipdvhgYsWAygp4BQxekBWFDkpWM3ZCVgC0LmvJxCk5S2kDAFLS9hU5ZV0jamB0RX5c31yWFrfoLfqp0N4WEe8xJtcPWPjZDBhSGLGwLumUcOyHXeF8cbfbhgenS-ftbA7sT_RYbGMYw5T11-TlWg8J3xzPc_L98su3i-vy9uvVzcXn29LUoplKraGuBedGWLu2prPQmE6ihLYXhlqJzFIBDdiu7ltEYGvatrRpda5JEJKfk3Lpm_7gdu7VNrpRx50K2qlj6Ve-oapl1zRd5rt_8nl5-yw9ipRL4FI0IrvvFzekKT8ZN6G5M8F7NJNiHCTjssnUh4XK7X7PmCY1umRwGLTHMCe1j6ttO8FpRvmCmhhSirh-WoeC2mesNuqQ8UFSwFXOOFvvjgPmfkT75DyGmoFPC4D54-8dxv2u6A1aF_er2uD-O-AvgNm8FA |
| CitedBy_id | crossref_primary_10_3390_cancers16051069 crossref_primary_10_1042_BST20191106 crossref_primary_10_1093_brain_awad195 crossref_primary_10_1182_bloodadvances_2020001535 crossref_primary_10_1016_j_cellsig_2021_110209 crossref_primary_10_3390_cells12050798 crossref_primary_10_1007_s12032_022_01671_6 crossref_primary_10_3389_fgene_2019_01134 crossref_primary_10_1182_bloodadvances_2023009798 crossref_primary_10_3390_ijms21218320 crossref_primary_10_1016_j_freeradbiomed_2021_03_018 crossref_primary_10_1016_j_ejcb_2024_151386 crossref_primary_10_1016_j_cellsig_2024_111094 crossref_primary_10_1007_s10555_019_09799_0 crossref_primary_10_3390_ijms20020445 |
| Cites_doi | 10.1016/j.devcel.2013.05.016 10.1101/gr.150482.112 10.1016/bs.acr.2016.01.006 10.1038/nrg3788 10.1128/MCB.00724-12 10.1172/JCI30117 10.1016/j.molcel.2008.10.015 10.1073/pnas.86.14.5434 10.1371/journal.pone.0069853 10.1038/nbt1279 10.1101/gad.924501 10.1038/nature08911 10.1016/0888-7543(88)90017-1 10.4161/epi.4.3.8484 10.1073/pnas.94.9.4273 10.1242/jcs.114.13.2363 10.1016/j.ccr.2006.08.026 10.1073/pnas.88.13.5680 10.1038/ja.2016.17 10.1038/nrg2665 10.1016/j.yexcr.2017.03.013 10.1002/hep.24539 10.1126/science.3296191 10.1128/MCB.02323-06 10.1074/jbc.M116.759134 10.1016/S0021-9258(17)31580-6 10.1042/BJ20081238 10.1038/nrm.2017.47 10.1084/jem.20170494 10.1038/nrg.2016.59 10.1128/MCB.05463-11 10.1128/MCB.01332-07 10.1128/MCB.8.1.71 10.1128/MCB.00731-13 10.1128/MCB.00161-15 10.1016/j.cell.2008.02.022 10.1371/journal.pgen.1006318 10.1016/j.molcel.2010.09.022 10.1038/35107085 10.1093/emboj/17.22.6573 10.1038/nbt.1685 10.1182/blood-2010-10-314427 10.1074/jbc.M808491200 10.1158/0008-5472.CAN-10-2821 10.1126/science.942798 10.1016/j.febslet.2004.08.053 10.1074/jbc.M109.021824 10.1016/j.biocel.2008.07.022 10.1093/nar/gkx951 10.1073/pnas.92.12.5510 10.1074/jbc.M901790200 10.1016/j.abb.2013.12.010 10.1074/jbc.M804578200 10.1128/MCB.02246-06 10.1371/journal.pgen.1004994 10.1016/j.molcel.2010.09.024 10.1371/journal.pone.0009644 |
| ContentType | Journal Article |
| Copyright | 2018 Elsevier Inc. Copyright © 2018 Elsevier Inc. All rights reserved. |
| Copyright_xml | – notice: 2018 Elsevier Inc. – notice: Copyright © 2018 Elsevier Inc. All rights reserved. |
| DBID | NPM AAYXX CITATION 7X8 OTOTI ADTPV AOWAS |
| DOI | 10.1016/j.yexcr.2018.03.020 |
| DatabaseName | PubMed CrossRef MEDLINE - Academic OSTI.GOV SwePub SwePub Articles |
| DatabaseTitle | PubMed CrossRef MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic PubMed |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1090-2422 |
| EndPage | 191 |
| ExternalDocumentID | oai_swepub_ki_se_489559 oai_prod_swepub_kib_ki_se_138038757 23082385 10_1016_j_yexcr_2018_03_020 29574021 S0014482718301587 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- --K --M -DZ -~X .~1 0R~ 1B1 1RT 1~. 1~5 4.4 457 4G. 5GY 5RE 5VS 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAXUO ABFNM ABFRF ABGSF ABJNI ABMAC ABOCM ABPPZ ABUDA ABYKQ ACDAQ ACGFO ACGFS ACNCT ACPRK ACRLP ADBBV ADEZE ADUVX AEBSH AEFWE AEHWI AEKER AENEX AFKWA AFTJW AFXIZ AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ AXJTR BKOJK BLXMC C45 CS3 DM4 DOVZS DU5 EBS EFBJH EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FIRID FNPLU FYGXN G-Q GBLVA IHE J1W K-O KOM L7B LG5 LX2 M41 MO0 N9A O-L O9- OAUVE OVD OZT P-8 P-9 P2P PC. PQQKQ Q38 RIG RNS ROL RPZ SCC SDF SDG SDP SES SPCBC SSU SSZ T5K TEORI TWZ VQA WH7 Y6R YZZ ZA5 ZCA ZMT ZU3 ~G- ~KM AAXKI AKRWK NPM .55 .GJ 29G 3O- 53G 9M8 AAQXK AAYXX ABEFU ABXDB ACKIV ADFGL ADMUD ADVLN AFJKZ AGHFR AGRDE AI. ASPBG AVWKF AZFZN CAG CITATION COF FA8 FEDTE FGOYB G-2 G8K HLW HVGLF HZ~ LPU MVM NEJ OHT R2- SBG SEW VH1 WUQ X7L X7M XOL XPP YYP ZGI ZKB 7X8 AALMO AAPBV ABPIF ABPTK ABQIS EFJIC OTOTI PQEST ABDPE ADTPV AOWAS |
| ID | FETCH-LOGICAL-c475t-aa044733c7ddfdc9d05c98e806b7c1d8e2d17050d94b6ee02f166156a05080783 |
| IEDL.DBID | AIKHN |
| ISSN | 0014-4827 1090-2422 |
| IngestDate | Thu Oct 31 04:28:06 EDT 2024 Wed Oct 30 04:54:31 EDT 2024 Fri May 19 00:37:13 EDT 2023 Sun Sep 29 07:48:03 EDT 2024 Thu Sep 26 17:42:58 EDT 2024 Wed Oct 16 00:51:24 EDT 2024 Fri Feb 23 02:34:33 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Keywords | Nucleosome-free region Chromatin Hypoxia-inducible transcription |
| Language | English |
| License | Copyright © 2018 Elsevier Inc. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c475t-aa044733c7ddfdc9d05c98e806b7c1d8e2d17050d94b6ee02f166156a05080783 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 29574021 |
| PQID | 2018669731 |
| PQPubID | 23479 |
| PageCount | 11 |
| ParticipantIDs | swepub_primary_oai_swepub_ki_se_489559 swepub_primary_oai_prod_swepub_kib_ki_se_138038757 osti_scitechconnect_23082385 proquest_miscellaneous_2018669731 crossref_primary_10_1016_j_yexcr_2018_03_020 pubmed_primary_29574021 elsevier_sciencedirect_doi_10_1016_j_yexcr_2018_03_020 |
| PublicationCentury | 2000 |
| PublicationDate | 2018-05-15 |
| PublicationDateYYYYMMDD | 2018-05-15 |
| PublicationDate_xml | – month: 05 year: 2018 text: 2018-05-15 day: 15 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Experimental cell research |
| PublicationTitleAlternate | Exp Cell Res |
| PublicationYear | 2018 |
| Publisher | Elsevier Inc |
| Publisher_xml | – name: Elsevier Inc |
| References | Schödel, Oikonomopoulos, Ragoussis, Pugh, Ratcliffe, Mole (bib15) 2011; 117 Tiana, Acosta-Iborra, Puente-Santamaría, Hernansanz-Agustin, Worsley-Hunt, Masson, García-Rio, Mole, Ratcliffe, Wasserman, Jimenez, Peso (bib43) 2018; 46 van Oevelen, Wang, Asp, Yan, Kaelin, Kluger, Dynlacht (bib59) 2008; 32 Matsumoto, Yasui, Mitchell, Krishna (bib58) 2010; 70 Yamashita, Ohneda, Nagano, Iemitsu, Makino, Tanaka, Miyauchi, Goto, Ohneda, Fujii-Kuriyama, Poellinger, Yamamoto (bib18) 2008; 28 Allis, Jenuwein (bib3) 2016; 17 Semenza, Nejfelt, Chi, Antonarakis (bib10) 1991; 88 Fujiki, Inamura, Miyayama, Matsuoka (bib26) 2017; 292 Lendahl, Lee, Yang, Poellinger (bib8) 2009; 10 Pollard, Loenarz, Mole, McDonough, Gleadle, Schofield, Ratcliffe (bib36) 2008; 416 Rankin, Biju, Liu, Unger, Rha, Johnson, Simon, Keith, Haase (bib24) 2007; 117 Weintraub, Tapscott, Davis, Thayer, Adam, Lassar, Miller (bib1) 1989; 86 Hirota-Takahata, Kobayashi, Kizuka, Ohyama, Kitamura-Miyazaki, Suzuki, Fujiwara, Nakajima, Ando (bib32) 2016; 69 Boulon, Westman, Hutten, Boisvert, Lamond (bib6) 2010; 40 Davie, Jacobs, Atkins, Potier, Christiaens, Halder, Aerts (bib46) 2015; 11 Ihnatko, Kubes, Takacova, Sedlakova, Sedlak, Pastorek, Kopacek, Pastorekova (bib23) 2006; 29 Fang, Zhu (bib2) 2017; 214 Ruas, Berchner-Pfannschmidt, Malik, Gradin, Fandrey, Roeder, Pereira, Poellinger (bib20) 2010; 285 Suzuki, Obara, Pan, Watanabe, Jishage, Minegishi, Yamamoto (bib52) 2011; 31 Koohy, Down, Hubbard (bib39) 2013; 8 Minchenko, Opentanova, Minchenko, Ogura, Esumi (bib35) 2004; 576 Tracy, Dibling, Spike, Knabb, Schumacker, Macleod (bib38) 2007; 27 Pescador, Villar, Cifuentes, Garcia-Rocha, Ortiz-Barahona, Vazquez, Ordoñez, Cuevas, Saez-Morales, Garcia-Bermejo, Landazuri, Guinovart, del Peso (bib33) 2010; 5 Mole, Blancher, Copley, Pollard, Gleadle, Ragoussis, Ratcliffe (bib14) 2009; 284 Tojo, Sekine, Hirano, Pan, Souma, Tsujita, Kawaguchi, Takeda, Takeda, Fong, Dan, Ichinose, Miyata, Yamamoto, Suzuki (bib16) 2015; 35 Ema, Taya, Yokotani, Sogawa, Matsuda, Fujii-Kuriyama (bib13) 1997; 94 Winter, Song, Mukherjee, Furey, Crawford (bib29) 2013; 23 Mahon, Hirota, Semenza (bib56) 2001 Schones, Cui, Cuddapah, Roh, Barski, Wang, Wei, Zhao (bib48) 2008; 132 McDonel, Costello, Hendrich (bib57) 2009; 41 Pawlus, Wang, Ware, Hu (bib25) 2012; 32 Allemand, Myers, Garcia-Bernardo, Harel-Bellan, Krainer, Muchardt (bib28) 2016; 12 Ho, Crabtree (bib54) 2010; 463 Meyer, Liu (bib47) 2014; 15 Kenneth, Mudie, van Uden, Rocha (bib53) 2009; 284 Makino, Cao, Svensson, Bertilsson, Asman, Tanaka, Cao, Berkenstam, Poellinger (bib17) 2001; 414 Sena, Wang, Hu (bib55) 2013; 33 Balestra, Strnad, Flückiger, Gönczy (bib27) 2013; 25 Biedler, Spengler (bib41) 1976; 191 Beyer, Kristensen, Jensen, Johansen, Staller (bib37) 2008; 283 Kallio, Okamoto, O'Brien, Carrero, Makino, Tanaka, Poellinger (bib19) 1998; 17 Mahtani, Willard (bib42) 1988; 2 Kim, Jeong, Park, Lee, Seo, Jung, Bae, Kim (bib45) 2007; 17 Holmquist-Mengelbier, Fredlund, Löfstedt, Noguera, Navarro, Nilsson, Pietras, Vallon-Christersson, Borg, Gradin, Poellinger, Påhlman (bib22) 2006; 10 Ozsolak, Song, Liu, Fisher (bib51) 2007; 25 Bansal, David, Farias, Waxman (bib21) 2016; 130 Portela, Esteller (bib49) 2010; 28 Bert, Johnson, Baxter, Cockerill (bib50) 2007; 27 Suzuki, Gradin, Poellinger, Yamamoto (bib12) 2017; 356 Majmundar, Wong, Simon (bib9) 2010; 40 Lai, Pugh (bib4) 2017; 18 Wang, Jiang, Rue, Semenza (bib11) 1995; 92 Semenza, Roth, Fang, Wang (bib34) 1994; 269 Kim, Jang, Lim, Won, Yoon, Park, Kim, Kim, Park, Ha, Kim (bib30) 2011; 54 Chan, La Thangue (bib44) 2001; 114 Maniatis, Goodbourn, Fischer (bib7) 1987; 236 Zhao, Liu, Shen, Ma, Zhang, Chen, Zhao, Yu, Zhang (bib31) 2014; 543 MacDonald, Howe (bib5) 2009; 4 Levy-Wilson, Fortier, Blackhart, McCarthy (bib40) 1988; 8 Chan (10.1016/j.yexcr.2018.03.020_bib44) 2001; 114 Bansal (10.1016/j.yexcr.2018.03.020_bib21) 2016; 130 Bert (10.1016/j.yexcr.2018.03.020_bib50) 2007; 27 Ema (10.1016/j.yexcr.2018.03.020_bib13) 1997; 94 Winter (10.1016/j.yexcr.2018.03.020_bib29) 2013; 23 Davie (10.1016/j.yexcr.2018.03.020_bib46) 2015; 11 Mahon (10.1016/j.yexcr.2018.03.020_bib56) 2001 Yamashita (10.1016/j.yexcr.2018.03.020_bib18) 2008; 28 Koohy (10.1016/j.yexcr.2018.03.020_bib39) 2013; 8 Semenza (10.1016/j.yexcr.2018.03.020_bib34) 1994; 269 Allis (10.1016/j.yexcr.2018.03.020_bib3) 2016; 17 Kallio (10.1016/j.yexcr.2018.03.020_bib19) 1998; 17 Suzuki (10.1016/j.yexcr.2018.03.020_bib12) 2017; 356 Allemand (10.1016/j.yexcr.2018.03.020_bib28) 2016; 12 Sena (10.1016/j.yexcr.2018.03.020_bib55) 2013; 33 Pollard (10.1016/j.yexcr.2018.03.020_bib36) 2008; 416 Lendahl (10.1016/j.yexcr.2018.03.020_bib8) 2009; 10 Levy-Wilson (10.1016/j.yexcr.2018.03.020_bib40) 1988; 8 Ozsolak (10.1016/j.yexcr.2018.03.020_bib51) 2007; 25 Fang (10.1016/j.yexcr.2018.03.020_bib2) 2017; 214 Wang (10.1016/j.yexcr.2018.03.020_bib11) 1995; 92 Ihnatko (10.1016/j.yexcr.2018.03.020_bib23) 2006; 29 MacDonald (10.1016/j.yexcr.2018.03.020_bib5) 2009; 4 Kim (10.1016/j.yexcr.2018.03.020_bib45) 2007; 17 Meyer (10.1016/j.yexcr.2018.03.020_bib47) 2014; 15 Schödel (10.1016/j.yexcr.2018.03.020_bib15) 2011; 117 Portela (10.1016/j.yexcr.2018.03.020_bib49) 2010; 28 McDonel (10.1016/j.yexcr.2018.03.020_bib57) 2009; 41 Biedler (10.1016/j.yexcr.2018.03.020_bib41) 1976; 191 Pawlus (10.1016/j.yexcr.2018.03.020_bib25) 2012; 32 Boulon (10.1016/j.yexcr.2018.03.020_bib6) 2010; 40 Matsumoto (10.1016/j.yexcr.2018.03.020_bib58) 2010; 70 Hirota-Takahata (10.1016/j.yexcr.2018.03.020_bib32) 2016; 69 Rankin (10.1016/j.yexcr.2018.03.020_bib24) 2007; 117 Balestra (10.1016/j.yexcr.2018.03.020_bib27) 2013; 25 Makino (10.1016/j.yexcr.2018.03.020_bib17) 2001; 414 Zhao (10.1016/j.yexcr.2018.03.020_bib31) 2014; 543 Pescador (10.1016/j.yexcr.2018.03.020_bib33) 2010; 5 Holmquist-Mengelbier (10.1016/j.yexcr.2018.03.020_bib22) 2006; 10 Ruas (10.1016/j.yexcr.2018.03.020_bib20) 2010; 285 Schones (10.1016/j.yexcr.2018.03.020_bib48) 2008; 132 Kim (10.1016/j.yexcr.2018.03.020_bib30) 2011; 54 Lai (10.1016/j.yexcr.2018.03.020_bib4) 2017; 18 Tojo (10.1016/j.yexcr.2018.03.020_bib16) 2015; 35 Semenza (10.1016/j.yexcr.2018.03.020_bib10) 1991; 88 Maniatis (10.1016/j.yexcr.2018.03.020_bib7) 1987; 236 Suzuki (10.1016/j.yexcr.2018.03.020_bib52) 2011; 31 Beyer (10.1016/j.yexcr.2018.03.020_bib37) 2008; 283 Ho (10.1016/j.yexcr.2018.03.020_bib54) 2010; 463 Kenneth (10.1016/j.yexcr.2018.03.020_bib53) 2009; 284 van Oevelen (10.1016/j.yexcr.2018.03.020_bib59) 2008; 32 Tiana (10.1016/j.yexcr.2018.03.020_bib43) 2018; 46 Mahtani (10.1016/j.yexcr.2018.03.020_bib42) 1988; 2 Fujiki (10.1016/j.yexcr.2018.03.020_bib26) 2017; 292 Tracy (10.1016/j.yexcr.2018.03.020_bib38) 2007; 27 Majmundar (10.1016/j.yexcr.2018.03.020_bib9) 2010; 40 Weintraub (10.1016/j.yexcr.2018.03.020_bib1) 1989; 86 Minchenko (10.1016/j.yexcr.2018.03.020_bib35) 2004; 576 Mole (10.1016/j.yexcr.2018.03.020_bib14) 2009; 284 |
| References_xml | – volume: 463 start-page: 474 year: 2010 end-page: 484 ident: bib54 article-title: Chromatin remodelling during development publication-title: Nature contributor: fullname: Crabtree – volume: 117 start-page: 207 year: 2011 end-page: 217 ident: bib15 article-title: High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq publication-title: Blood contributor: fullname: Mole – volume: 191 start-page: 185 year: 1976 end-page: 187 ident: bib41 article-title: Metaphase chromosome anomaly: association with drug resistance and cell-specific products publication-title: Science contributor: fullname: Spengler – volume: 27 start-page: 2870 year: 2007 end-page: 2885 ident: bib50 article-title: A modular enhancer is differentially regulated by GATA and NFAT elements that direct different tissue-specific patterns of nucleosome positioning and inducible chromatin remodeling publication-title: Mol. Cell. Biol. contributor: fullname: Cockerill – volume: 18 start-page: 548 year: 2017 end-page: 562 ident: bib4 article-title: Understanding nucleosome dynamics and their links to gene expression and DNA replication publication-title: Nat. Rev. Mol. Cell. Biol. contributor: fullname: Pugh – volume: 214 start-page: 1861 year: 2017 end-page: 1876 ident: bib2 article-title: Dynamic balance between master transcription factors determines the fates and functions of CD4 T cell and innate lymphoid cell subsets publication-title: J. Exp. Med. contributor: fullname: Zhu – volume: 356 start-page: 182 year: 2017 end-page: 186 ident: bib12 article-title: Regulation of hypoxia-inducible gene expression after HIF activation publication-title: Exp. Cell Res. contributor: fullname: Yamamoto – volume: 8 start-page: e69853 year: 2013 ident: bib39 article-title: Chromatin accessibility data sets show bias due to sequence specificity of the DNase I enzyme publication-title: PLoS One contributor: fullname: Hubbard – volume: 88 start-page: 5680 year: 1991 end-page: 5684 ident: bib10 article-title: Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Antonarakis – volume: 69 start-page: 747 year: 2016 end-page: 753 ident: bib32 article-title: Studies on novel HIF activators, A-503451s.I. Producing organism, fermentation, isolation and structural elucidation publication-title: J. Antibiot. contributor: fullname: Ando – volume: 132 start-page: 887 year: 2008 end-page: 898 ident: bib48 article-title: Dynamic regulation of nucleosome positioning in the human genome publication-title: Cell contributor: fullname: Zhao – volume: 414 start-page: 550 year: 2001 end-page: 554 ident: bib17 article-title: Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression publication-title: Nature contributor: fullname: Poellinger – volume: 285 start-page: 2601 year: 2010 end-page: 2609 ident: bib20 article-title: Complex regulation of the transactivation function of hypoxia-inducible factor-1 alpha by direct interaction with two distinct domains of the CREB-binding protein/p300 publication-title: J. Biol. Chem. contributor: fullname: Poellinger – volume: 28 start-page: 1057 year: 2010 end-page: 1068 ident: bib49 article-title: Epigenetic modifications and human disease publication-title: Nat. Biotechnol. contributor: fullname: Esteller – volume: 35 start-page: 2658 year: 2015 end-page: 2672 ident: bib16 article-title: Hypoxia signaling cascade for erythropoietin production in hepatocytes publication-title: Mol. Cell. Biol. contributor: fullname: Suzuki – volume: 292 start-page: 7942 year: 2017 end-page: 7953 ident: bib26 article-title: Involvement of Notch1 signaling in malignant progression of A549 cells subjected to prolonged cadmium exposure publication-title: J. Biol. Chem. contributor: fullname: Matsuoka – volume: 236 start-page: 1237 year: 1987 end-page: 1245 ident: bib7 article-title: Regulation of inducible and tissue-specific gene expression publication-title: Science contributor: fullname: Fischer – volume: 10 start-page: 821 year: 2009 end-page: 832 ident: bib8 article-title: Generating specificity and diversity in the transcriptional response to hypoxia publication-title: Nat. Rev. Genet. contributor: fullname: Poellinger – volume: 23 start-page: 1118 year: 2013 end-page: 11129 ident: bib29 article-title: DNase-seq predicts regions of rotational nucleosome stability across diverse human cell types publication-title: Genome Res. contributor: fullname: Crawford – volume: 283 start-page: 36542 year: 2008 end-page: 36552 ident: bib37 article-title: The histone demethylases JMJD1A and JMJD2B are transcriptional targets of hypoxia-inducible factor HIF publication-title: J. Biol. Chem. contributor: fullname: Staller – volume: 117 start-page: 1068 year: 2007 end-page: 1077 ident: bib24 article-title: Hypoxia-inducible factor-2 (HIF2) regulates hepatic erythropoietin in vivo publication-title: J. Clin. Investig. contributor: fullname: Haase – volume: 269 start-page: 23757 year: 1994 end-page: 23763 ident: bib34 article-title: Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1 publication-title: J. Biol. Chem. contributor: fullname: Wang – volume: 4 start-page: 139 year: 2009 end-page: 143 ident: bib5 article-title: Histone acetylation: where to go and how to get there publication-title: Epigenetics contributor: fullname: Howe – volume: 46 start-page: 120 year: 2018 end-page: 133 ident: bib43 article-title: The SIN3A histone deacetylase complex is required for a complete transcriptional response to hypoxia publication-title: Nucleic Acids Res. contributor: fullname: Peso – volume: 32 start-page: 4595 year: 2012 end-page: 4610 ident: bib25 article-title: Upstream stimulatory factor 2 and hypoxia-inducible factor 2α (HIF2α) cooperatively activate HIF2 target genes during hypoxia publication-title: Mol. Cell. Biol. contributor: fullname: Hu – volume: 576 start-page: 14 year: 2004 end-page: 20 ident: bib35 article-title: Hypoxia induces transcription of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 gene via hypoxia-inducible factor-1alpha activation publication-title: FEBS Lett. contributor: fullname: Esumi – volume: 27 start-page: 6229 year: 2007 end-page: 6242 ident: bib38 article-title: BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy publication-title: Mol. Cell. Biol. contributor: fullname: Macleod – volume: 284 start-page: 16767 year: 2009 end-page: 16775 ident: bib14 article-title: Genome-wide association of hypoxia-inducible factor (HIF)−1alpha and HIF2alpha DNA binding with expression profiling of hypoxia-inducible transcripts publication-title: J. Biol. Chem. contributor: fullname: Ratcliffe – volume: 17 start-page: 647 year: 2007 end-page: 651 ident: bib45 article-title: Regulation of the HIF1alpha stability by histone deacetylases publication-title: Oncol. Rep. contributor: fullname: Kim – volume: 28 start-page: 1285 year: 2008 end-page: 1297 ident: bib18 article-title: Abnormal heart development and lung remodeling in mice lacking the hypoxia-inducible factor-related basic helix-loop-helix PAS protein NEPAS publication-title: Mol. Cell. Biol. contributor: fullname: Yamamoto – volume: 284 start-page: 4123 year: 2009 end-page: 4131 ident: bib53 article-title: SWI/SNF regulates the cellular response to hypoxia publication-title: J. Biol. Chem. contributor: fullname: Rocha – volume: 29 start-page: 1025 year: 2006 end-page: 1033 ident: bib23 article-title: Extracellular acidosis elevates carbonic anhydrase IX in human glioblastoma cells via transcriptional modulation that does not depend on hypoxia publication-title: Int. J. Oncol. contributor: fullname: Pastorekova – volume: 41 start-page: 108 year: 2009 end-page: 116 ident: bib57 article-title: Keeping things quiet: roles of NuRD and Sin3 co-repressor complexes during mammalian development publication-title: Int. J. Biochem. Cell. Biol. contributor: fullname: Hendrich – volume: 32 start-page: 359 year: 2008 end-page: 370 ident: bib59 article-title: A role for mammalian Sin3 in permanent gene silencing publication-title: Mol. Cell contributor: fullname: Dynlacht – volume: 10 start-page: 413 year: 2006 end-page: 423 ident: bib22 article-title: Recruitment of HIF1alpha and HIF2alpha to common target genes is differentially regulated in neuroblastoma: HIF2alpha promotes an aggressive phenotype publication-title: Cancer Cell contributor: fullname: Påhlman – volume: 25 start-page: 555 year: 2013 end-page: 571 ident: bib27 article-title: Discovering regulators of centriole biogenesis through siRNA-based functional genomics in human cells publication-title: Dev. Cell contributor: fullname: Gönczy – volume: 86 start-page: 5434 year: 1989 end-page: 5438 ident: bib1 article-title: Activation of muscle specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Miller – volume: 17 start-page: 6573 year: 1998 end-page: 6586 ident: bib19 article-title: Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha publication-title: EMBO J. contributor: fullname: Poellinger – volume: 40 start-page: 294 year: 2010 end-page: 309 ident: bib9 article-title: Hypoxia-inducible factors and the response to hypoxic stress publication-title: Mol. Cell contributor: fullname: Simon – volume: 130 start-page: 113 year: 2016 end-page: 135 ident: bib21 article-title: Emerging roles of epigenetic regulator Sin3 in cancer publication-title: Adv. Cancer Res. contributor: fullname: Waxman – volume: 40 start-page: 216 year: 2010 end-page: 227 ident: bib6 article-title: The nucleolus under stress publication-title: Mol. Cell contributor: fullname: Lamond – volume: 25 start-page: 244 year: 2007 end-page: 248 ident: bib51 article-title: High-throughput mapping of the chromatin structure of human promoters publication-title: Nat. Biotechnol. contributor: fullname: Fisher – volume: 94 start-page: 4273 year: 1997 end-page: 4278 ident: bib13 article-title: A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Fujii-Kuriyama – volume: 5 start-page: e9644 year: 2010 ident: bib33 article-title: Hypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1 publication-title: PLoS One contributor: fullname: del Peso – volume: 31 start-page: 3896 year: 2011 end-page: 3905 ident: bib52 article-title: Specific contribution of the erythropoietin gene 3' enhancer to hepatic erythropoiesis after late embryonic stage publication-title: Mol. Cell. Biol. contributor: fullname: Yamamoto – volume: 54 start-page: 1661 year: 2011 end-page: 1678 ident: bib30 article-title: Role of cyclophilin B in tumorigenesis and cisplatin resistance in hepatocellular carcinoma in humans publication-title: Hepatology contributor: fullname: Kim – volume: 8 start-page: 71 year: 1988 end-page: 80 ident: bib40 article-title: DNase I- and micrococcal nuclease-hypersensitive sites in the human apolipoprotein B gene are tissue specific publication-title: Mol. Cell. Biol. contributor: fullname: McCarthy – volume: 33 start-page: 3849 year: 2013 end-page: 3863 ident: bib55 article-title: BRG1 and BRM chromatin-remodeling complexes regulate the hypoxia response by acting as coactivators for a subset of hypoxia inducible transcription factor target genes publication-title: Mol. Cell. Biol. contributor: fullname: Hu – volume: 416 start-page: 387 year: 2008 end-page: 394 ident: bib36 article-title: Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)–1alpha publication-title: Biochem. J. contributor: fullname: Ratcliffe – volume: 15 start-page: 709 year: 2014 end-page: 721 ident: bib47 article-title: Identifying and mitigating bias in next-generation sequencing methods for chromatin biology publication-title: Nat. Rev. Genet. contributor: fullname: Liu – volume: 92 start-page: 5510 year: 1995 end-page: 5514 ident: bib11 article-title: Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Semenza – volume: 2 start-page: 294 year: 1988 end-page: 301 ident: bib42 article-title: A primary genetic map of the pericentromeric region of the human X chromosome publication-title: Genomics contributor: fullname: Willard – volume: 12 start-page: e1006318 year: 2016 ident: bib28 article-title: A broad set of chromatin factors influences splicing publication-title: PLoS Genet. contributor: fullname: Muchardt – volume: 70 start-page: 10019 year: 2010 end-page: 10023 ident: bib58 article-title: Imaging cycling tumor hypoxia publication-title: Cancer Res. contributor: fullname: Krishna – volume: 17 start-page: 487 year: 2016 end-page: 500 ident: bib3 article-title: The molecular hallmarks of epigenetic control publication-title: Nat. Rev. Genet. contributor: fullname: Jenuwein – volume: 114 start-page: 2363 year: 2001 end-page: 2373 ident: bib44 article-title: p300/CBP proteins: HATs for transcriptional bridges and scaffolds publication-title: J. Cell Sci. contributor: fullname: La Thangue – volume: 11 start-page: e1004994 year: 2015 ident: bib46 article-title: Discovery of transcription factors and regulatory regions driving in vivo tumor development by ATAC-seq and FAIRE-seq open chromatin profiling publication-title: PLoS Genet. contributor: fullname: Aerts – volume: 543 start-page: 40 year: 2014 end-page: 47 ident: bib31 article-title: Hypoxia induces peroxisome proliferator-activated receptor γ expression via HIF-1-dependent mechanisms in HepG2 cell line publication-title: Arch. Biochem. Biophys. contributor: fullname: Zhang – start-page: 2675 year: 2001 end-page: 2686 ident: bib56 article-title: FIH-1: a novel protein that interacts with HIF1alpha and VHL to mediate repression of HIF1 transcriptional activity publication-title: Genes Dev. 15 contributor: fullname: Semenza – volume: 25 start-page: 555 year: 2013 ident: 10.1016/j.yexcr.2018.03.020_bib27 article-title: Discovering regulators of centriole biogenesis through siRNA-based functional genomics in human cells publication-title: Dev. Cell doi: 10.1016/j.devcel.2013.05.016 contributor: fullname: Balestra – volume: 23 start-page: 1118 year: 2013 ident: 10.1016/j.yexcr.2018.03.020_bib29 article-title: DNase-seq predicts regions of rotational nucleosome stability across diverse human cell types publication-title: Genome Res. doi: 10.1101/gr.150482.112 contributor: fullname: Winter – volume: 130 start-page: 113 year: 2016 ident: 10.1016/j.yexcr.2018.03.020_bib21 article-title: Emerging roles of epigenetic regulator Sin3 in cancer publication-title: Adv. Cancer Res. doi: 10.1016/bs.acr.2016.01.006 contributor: fullname: Bansal – volume: 15 start-page: 709 year: 2014 ident: 10.1016/j.yexcr.2018.03.020_bib47 article-title: Identifying and mitigating bias in next-generation sequencing methods for chromatin biology publication-title: Nat. Rev. Genet. doi: 10.1038/nrg3788 contributor: fullname: Meyer – volume: 32 start-page: 4595 year: 2012 ident: 10.1016/j.yexcr.2018.03.020_bib25 article-title: Upstream stimulatory factor 2 and hypoxia-inducible factor 2α (HIF2α) cooperatively activate HIF2 target genes during hypoxia publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.00724-12 contributor: fullname: Pawlus – volume: 117 start-page: 1068 year: 2007 ident: 10.1016/j.yexcr.2018.03.020_bib24 article-title: Hypoxia-inducible factor-2 (HIF2) regulates hepatic erythropoietin in vivo publication-title: J. Clin. Investig. doi: 10.1172/JCI30117 contributor: fullname: Rankin – volume: 32 start-page: 359 year: 2008 ident: 10.1016/j.yexcr.2018.03.020_bib59 article-title: A role for mammalian Sin3 in permanent gene silencing publication-title: Mol. Cell doi: 10.1016/j.molcel.2008.10.015 contributor: fullname: van Oevelen – volume: 86 start-page: 5434 year: 1989 ident: 10.1016/j.yexcr.2018.03.020_bib1 article-title: Activation of muscle specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.86.14.5434 contributor: fullname: Weintraub – volume: 8 start-page: e69853 year: 2013 ident: 10.1016/j.yexcr.2018.03.020_bib39 article-title: Chromatin accessibility data sets show bias due to sequence specificity of the DNase I enzyme publication-title: PLoS One doi: 10.1371/journal.pone.0069853 contributor: fullname: Koohy – volume: 25 start-page: 244 year: 2007 ident: 10.1016/j.yexcr.2018.03.020_bib51 article-title: High-throughput mapping of the chromatin structure of human promoters publication-title: Nat. Biotechnol. doi: 10.1038/nbt1279 contributor: fullname: Ozsolak – start-page: 2675 year: 2001 ident: 10.1016/j.yexcr.2018.03.020_bib56 article-title: FIH-1: a novel protein that interacts with HIF1alpha and VHL to mediate repression of HIF1 transcriptional activity publication-title: Genes Dev. 15 doi: 10.1101/gad.924501 contributor: fullname: Mahon – volume: 463 start-page: 474 year: 2010 ident: 10.1016/j.yexcr.2018.03.020_bib54 article-title: Chromatin remodelling during development publication-title: Nature doi: 10.1038/nature08911 contributor: fullname: Ho – volume: 2 start-page: 294 year: 1988 ident: 10.1016/j.yexcr.2018.03.020_bib42 article-title: A primary genetic map of the pericentromeric region of the human X chromosome publication-title: Genomics doi: 10.1016/0888-7543(88)90017-1 contributor: fullname: Mahtani – volume: 4 start-page: 139 year: 2009 ident: 10.1016/j.yexcr.2018.03.020_bib5 article-title: Histone acetylation: where to go and how to get there publication-title: Epigenetics doi: 10.4161/epi.4.3.8484 contributor: fullname: MacDonald – volume: 94 start-page: 4273 year: 1997 ident: 10.1016/j.yexcr.2018.03.020_bib13 article-title: A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.94.9.4273 contributor: fullname: Ema – volume: 114 start-page: 2363 year: 2001 ident: 10.1016/j.yexcr.2018.03.020_bib44 article-title: p300/CBP proteins: HATs for transcriptional bridges and scaffolds publication-title: J. Cell Sci. doi: 10.1242/jcs.114.13.2363 contributor: fullname: Chan – volume: 10 start-page: 413 year: 2006 ident: 10.1016/j.yexcr.2018.03.020_bib22 article-title: Recruitment of HIF1alpha and HIF2alpha to common target genes is differentially regulated in neuroblastoma: HIF2alpha promotes an aggressive phenotype publication-title: Cancer Cell doi: 10.1016/j.ccr.2006.08.026 contributor: fullname: Holmquist-Mengelbier – volume: 88 start-page: 5680 year: 1991 ident: 10.1016/j.yexcr.2018.03.020_bib10 article-title: Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.88.13.5680 contributor: fullname: Semenza – volume: 69 start-page: 747 year: 2016 ident: 10.1016/j.yexcr.2018.03.020_bib32 article-title: Studies on novel HIF activators, A-503451s.I. Producing organism, fermentation, isolation and structural elucidation publication-title: J. Antibiot. doi: 10.1038/ja.2016.17 contributor: fullname: Hirota-Takahata – volume: 10 start-page: 821 year: 2009 ident: 10.1016/j.yexcr.2018.03.020_bib8 article-title: Generating specificity and diversity in the transcriptional response to hypoxia publication-title: Nat. Rev. Genet. doi: 10.1038/nrg2665 contributor: fullname: Lendahl – volume: 356 start-page: 182 year: 2017 ident: 10.1016/j.yexcr.2018.03.020_bib12 article-title: Regulation of hypoxia-inducible gene expression after HIF activation publication-title: Exp. Cell Res. doi: 10.1016/j.yexcr.2017.03.013 contributor: fullname: Suzuki – volume: 54 start-page: 1661 year: 2011 ident: 10.1016/j.yexcr.2018.03.020_bib30 article-title: Role of cyclophilin B in tumorigenesis and cisplatin resistance in hepatocellular carcinoma in humans publication-title: Hepatology doi: 10.1002/hep.24539 contributor: fullname: Kim – volume: 236 start-page: 1237 year: 1987 ident: 10.1016/j.yexcr.2018.03.020_bib7 article-title: Regulation of inducible and tissue-specific gene expression publication-title: Science doi: 10.1126/science.3296191 contributor: fullname: Maniatis – volume: 27 start-page: 2870 year: 2007 ident: 10.1016/j.yexcr.2018.03.020_bib50 article-title: A modular enhancer is differentially regulated by GATA and NFAT elements that direct different tissue-specific patterns of nucleosome positioning and inducible chromatin remodeling publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.02323-06 contributor: fullname: Bert – volume: 292 start-page: 7942 year: 2017 ident: 10.1016/j.yexcr.2018.03.020_bib26 article-title: Involvement of Notch1 signaling in malignant progression of A549 cells subjected to prolonged cadmium exposure publication-title: J. Biol. Chem. doi: 10.1074/jbc.M116.759134 contributor: fullname: Fujiki – volume: 269 start-page: 23757 year: 1994 ident: 10.1016/j.yexcr.2018.03.020_bib34 article-title: Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1 publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(17)31580-6 contributor: fullname: Semenza – volume: 416 start-page: 387 year: 2008 ident: 10.1016/j.yexcr.2018.03.020_bib36 article-title: Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)–1alpha publication-title: Biochem. J. doi: 10.1042/BJ20081238 contributor: fullname: Pollard – volume: 18 start-page: 548 year: 2017 ident: 10.1016/j.yexcr.2018.03.020_bib4 article-title: Understanding nucleosome dynamics and their links to gene expression and DNA replication publication-title: Nat. Rev. Mol. Cell. Biol. doi: 10.1038/nrm.2017.47 contributor: fullname: Lai – volume: 214 start-page: 1861 year: 2017 ident: 10.1016/j.yexcr.2018.03.020_bib2 article-title: Dynamic balance between master transcription factors determines the fates and functions of CD4 T cell and innate lymphoid cell subsets publication-title: J. Exp. Med. doi: 10.1084/jem.20170494 contributor: fullname: Fang – volume: 17 start-page: 487 year: 2016 ident: 10.1016/j.yexcr.2018.03.020_bib3 article-title: The molecular hallmarks of epigenetic control publication-title: Nat. Rev. Genet. doi: 10.1038/nrg.2016.59 contributor: fullname: Allis – volume: 31 start-page: 3896 year: 2011 ident: 10.1016/j.yexcr.2018.03.020_bib52 article-title: Specific contribution of the erythropoietin gene 3' enhancer to hepatic erythropoiesis after late embryonic stage publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.05463-11 contributor: fullname: Suzuki – volume: 28 start-page: 1285 year: 2008 ident: 10.1016/j.yexcr.2018.03.020_bib18 article-title: Abnormal heart development and lung remodeling in mice lacking the hypoxia-inducible factor-related basic helix-loop-helix PAS protein NEPAS publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.01332-07 contributor: fullname: Yamashita – volume: 8 start-page: 71 year: 1988 ident: 10.1016/j.yexcr.2018.03.020_bib40 article-title: DNase I- and micrococcal nuclease-hypersensitive sites in the human apolipoprotein B gene are tissue specific publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.8.1.71 contributor: fullname: Levy-Wilson – volume: 33 start-page: 3849 year: 2013 ident: 10.1016/j.yexcr.2018.03.020_bib55 article-title: BRG1 and BRM chromatin-remodeling complexes regulate the hypoxia response by acting as coactivators for a subset of hypoxia inducible transcription factor target genes publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.00731-13 contributor: fullname: Sena – volume: 35 start-page: 2658 year: 2015 ident: 10.1016/j.yexcr.2018.03.020_bib16 article-title: Hypoxia signaling cascade for erythropoietin production in hepatocytes publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.00161-15 contributor: fullname: Tojo – volume: 132 start-page: 887 year: 2008 ident: 10.1016/j.yexcr.2018.03.020_bib48 article-title: Dynamic regulation of nucleosome positioning in the human genome publication-title: Cell doi: 10.1016/j.cell.2008.02.022 contributor: fullname: Schones – volume: 12 start-page: e1006318 year: 2016 ident: 10.1016/j.yexcr.2018.03.020_bib28 article-title: A broad set of chromatin factors influences splicing publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1006318 contributor: fullname: Allemand – volume: 40 start-page: 294 year: 2010 ident: 10.1016/j.yexcr.2018.03.020_bib9 article-title: Hypoxia-inducible factors and the response to hypoxic stress publication-title: Mol. Cell doi: 10.1016/j.molcel.2010.09.022 contributor: fullname: Majmundar – volume: 414 start-page: 550 year: 2001 ident: 10.1016/j.yexcr.2018.03.020_bib17 article-title: Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression publication-title: Nature doi: 10.1038/35107085 contributor: fullname: Makino – volume: 17 start-page: 6573 year: 1998 ident: 10.1016/j.yexcr.2018.03.020_bib19 article-title: Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha publication-title: EMBO J. doi: 10.1093/emboj/17.22.6573 contributor: fullname: Kallio – volume: 28 start-page: 1057 year: 2010 ident: 10.1016/j.yexcr.2018.03.020_bib49 article-title: Epigenetic modifications and human disease publication-title: Nat. Biotechnol. doi: 10.1038/nbt.1685 contributor: fullname: Portela – volume: 117 start-page: 207 year: 2011 ident: 10.1016/j.yexcr.2018.03.020_bib15 article-title: High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq publication-title: Blood doi: 10.1182/blood-2010-10-314427 contributor: fullname: Schödel – volume: 284 start-page: 4123 year: 2009 ident: 10.1016/j.yexcr.2018.03.020_bib53 article-title: SWI/SNF regulates the cellular response to hypoxia publication-title: J. Biol. Chem. doi: 10.1074/jbc.M808491200 contributor: fullname: Kenneth – volume: 70 start-page: 10019 year: 2010 ident: 10.1016/j.yexcr.2018.03.020_bib58 article-title: Imaging cycling tumor hypoxia publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-10-2821 contributor: fullname: Matsumoto – volume: 191 start-page: 185 year: 1976 ident: 10.1016/j.yexcr.2018.03.020_bib41 article-title: Metaphase chromosome anomaly: association with drug resistance and cell-specific products publication-title: Science doi: 10.1126/science.942798 contributor: fullname: Biedler – volume: 17 start-page: 647 year: 2007 ident: 10.1016/j.yexcr.2018.03.020_bib45 article-title: Regulation of the HIF1alpha stability by histone deacetylases publication-title: Oncol. Rep. contributor: fullname: Kim – volume: 29 start-page: 1025 year: 2006 ident: 10.1016/j.yexcr.2018.03.020_bib23 article-title: Extracellular acidosis elevates carbonic anhydrase IX in human glioblastoma cells via transcriptional modulation that does not depend on hypoxia publication-title: Int. J. Oncol. contributor: fullname: Ihnatko – volume: 576 start-page: 14 year: 2004 ident: 10.1016/j.yexcr.2018.03.020_bib35 article-title: Hypoxia induces transcription of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 gene via hypoxia-inducible factor-1alpha activation publication-title: FEBS Lett. doi: 10.1016/j.febslet.2004.08.053 contributor: fullname: Minchenko – volume: 285 start-page: 2601 year: 2010 ident: 10.1016/j.yexcr.2018.03.020_bib20 article-title: Complex regulation of the transactivation function of hypoxia-inducible factor-1 alpha by direct interaction with two distinct domains of the CREB-binding protein/p300 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M109.021824 contributor: fullname: Ruas – volume: 41 start-page: 108 year: 2009 ident: 10.1016/j.yexcr.2018.03.020_bib57 article-title: Keeping things quiet: roles of NuRD and Sin3 co-repressor complexes during mammalian development publication-title: Int. J. Biochem. Cell. Biol. doi: 10.1016/j.biocel.2008.07.022 contributor: fullname: McDonel – volume: 46 start-page: 120 year: 2018 ident: 10.1016/j.yexcr.2018.03.020_bib43 article-title: The SIN3A histone deacetylase complex is required for a complete transcriptional response to hypoxia publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkx951 contributor: fullname: Tiana – volume: 92 start-page: 5510 year: 1995 ident: 10.1016/j.yexcr.2018.03.020_bib11 article-title: Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.92.12.5510 contributor: fullname: Wang – volume: 284 start-page: 16767 year: 2009 ident: 10.1016/j.yexcr.2018.03.020_bib14 article-title: Genome-wide association of hypoxia-inducible factor (HIF)−1alpha and HIF2alpha DNA binding with expression profiling of hypoxia-inducible transcripts publication-title: J. Biol. Chem. doi: 10.1074/jbc.M901790200 contributor: fullname: Mole – volume: 543 start-page: 40 year: 2014 ident: 10.1016/j.yexcr.2018.03.020_bib31 article-title: Hypoxia induces peroxisome proliferator-activated receptor γ expression via HIF-1-dependent mechanisms in HepG2 cell line publication-title: Arch. Biochem. Biophys. doi: 10.1016/j.abb.2013.12.010 contributor: fullname: Zhao – volume: 283 start-page: 36542 year: 2008 ident: 10.1016/j.yexcr.2018.03.020_bib37 article-title: The histone demethylases JMJD1A and JMJD2B are transcriptional targets of hypoxia-inducible factor HIF publication-title: J. Biol. Chem. doi: 10.1074/jbc.M804578200 contributor: fullname: Beyer – volume: 27 start-page: 6229 year: 2007 ident: 10.1016/j.yexcr.2018.03.020_bib38 article-title: BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.02246-06 contributor: fullname: Tracy – volume: 11 start-page: e1004994 year: 2015 ident: 10.1016/j.yexcr.2018.03.020_bib46 article-title: Discovery of transcription factors and regulatory regions driving in vivo tumor development by ATAC-seq and FAIRE-seq open chromatin profiling publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1004994 contributor: fullname: Davie – volume: 40 start-page: 216 year: 2010 ident: 10.1016/j.yexcr.2018.03.020_bib6 article-title: The nucleolus under stress publication-title: Mol. Cell doi: 10.1016/j.molcel.2010.09.024 contributor: fullname: Boulon – volume: 5 start-page: e9644 year: 2010 ident: 10.1016/j.yexcr.2018.03.020_bib33 article-title: Hypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1 publication-title: PLoS One doi: 10.1371/journal.pone.0009644 contributor: fullname: Pescador |
| SSID | ssj0008816 |
| Score | 2.3866549 |
| Snippet | Hypoxia causes dramatic changes in gene expression profiles, and the mechanism of hypoxia-inducible transcription has been analyzed for use as a model system... Highlights: • Nucleosome-free regions (NFRs) are established in some gene promoters in a hypoxia-dependent manner. • Hypoxia-inducible NFR (iNFR) formation... |
| SourceID | swepub osti proquest crossref pubmed elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 181 |
| SubjectTerms | 60 APPLIED LIFE SCIENCES ANOXIA Chromatin GENE REGULATION Hypoxia-inducible transcription Medicin och hälsovetenskap Nucleosome-free region NUCLEOSOMES TRANSCRIPTION FACTORS |
| Title | HIF-dependent and reversible nucleosome disassembly in hypoxia-inducible gene promoters |
| URI | https://dx.doi.org/10.1016/j.yexcr.2018.03.020 https://www.ncbi.nlm.nih.gov/pubmed/29574021 https://search.proquest.com/docview/2018669731 https://www.osti.gov/biblio/23082385 http://kipublications.ki.se/Default.aspx?queryparsed=id:138038757 |
| Volume | 366 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEB6SDYVeQtNX3DxwofRUNX5IlnwMocumpTk1NDchSzJ1m9hLdheyl_72zMj2QsvSQw8-WJox8ow0mrFH3wC8k_T1XuSWpTgbGPepZyU3ljl0nb1NhEoFnUb-elXMrvnnG3GzAxfjWRhKqxxsf2_Tg7UeWs4GaZ7Nm4bO-GIwoDI0rjhJhZK7sBd-Ek1g7_zyy-xqY5CVChVQiZ4Rwwg-FNK81v7BEi5oqgLYKdX93r5BTTpcc9v80L9ARsPGNH0G-4NHGZ_3gz6AHd8-hyd9jcn1C_g-u5yysdTtMjatiwm16R6Xwq2PW4Iz7hbdnY9ds0BH2t9Vt-u4aeMf63n30BiGMfvKBlqcaj6eh_Q9ZH8J19NP3y5mbKimwCyXYsmMSTiXeW6lc7WzpUuELZVXSVFJmzrlM0fQOokreVV4n2R1inu3KAy2ESh9_gombdf6Q4iVKqQzvDIYS_G8LhSS5rnjdW0y6SsTwYdRhHreg2boMZvspw4S1yRxneQaJR5BMYpZ_6F7jWb934zHpBRiIsRbS6lByJUFCB4lIng7KkvjoqE_Iab13WoRnlEUVLUrgte9FjcDzUohMajGnqxX66aHkLhpW9ND-6-GLr3wOs0VpQEIGcH7LUwbeqLlikD_3vzvOx_BU7qjBIZUHMNkeb_yJ-gXLatT2P34Oz0dZv8jfr0Niw |
| link.rule.ids | 230,315,783,787,888,4511,24130,27938,27939,45599,45693 |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELbKVoheEG8CBYyEOGE1Dzt2jlXFKkvbPbWiN8uxHTXQJqvurtT9951xkpVAKw4ccrFnomRmPJ5Jxt8Q8kXi13uRWZaANTDuE88KbixzEDp7GwuVCDyNfD7Py0v-40pc7ZGT8SwMllUOvr_36cFbDyNHgzSPFk2DZ3whGVApOFcwUqHkI7IP0UABxr5_PDst51uHrFTogIr0DBlG8KFQ5rXx9xZxQRMVwE6x7_fuDWrSwZrbFYf-BTIaNqbpM_J0iCjpcf_Qz8meb1-Qx32Pyc1L8rOcTdnY6nZFTesoojbdwVK48bRFOONu2d166polBNL-trrZ0Kal15tFd98YBjn72gZaMDVPF6F8D9hfkcvp94uTkg3dFJjlUqyYMTHnMsusdK52tnCxsIXyKs4raROnfOoQWid2Ba9y7-O0TmDvFrmBMQSlz16TSdu1_i2hSuXSGV4ZyKV4VucKSLPM8bo2qfSVici3UYR60YNm6LGa7JcOEtcocR1nGiQekXwUs_5D9xrc-r8ZD1EpyISItxZLg4ArDRA8SkTk86gsDYsG_4SY1nfrZbhHnmPXroi86bW4fdC0EBKSaphJe7VuZxCJG7c1PYz_bvDSS6-TTGEZgJAR-bqDaUuPtFwh6N-7_33nT-RJeXF-ps9m89P35ABnsJghEYdksrpb-w8QI62qj8MaeAAckQ-I |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=HIF-dependent+and+reversible+nucleosome+disassembly+in+hypoxia-inducible+gene+promoters&rft.jtitle=Experimental+cell+research&rft.au=Suzuki%2C+N&rft.au=Vojnovic%2C+N&rft.au=Lee%2C+K-L&rft.au=Yang%2C+H&rft.date=2018-05-15&rft.issn=0014-4827&rft.volume=366&rft.issue=2&rft.spage=181&rft_id=info:doi/10.1016%2Fj.yexcr.2018.03.020&rft.externalDocID=oai_swepub_ki_se_489559 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0014-4827&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0014-4827&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0014-4827&client=summon |