Results from a pilot study on amiodarone administration in monogenic frontotemporal dementia with granulin mutation

• Published in: Neurological sciences Vol. 35; no. 8; pp. 1215 - 1219
• Main Authors: Alberici, A., Archetti, S., Pilotto, A., Premi, E., Cosseddu, M., Bianchetti, A., Semeraro, F., Salvetti, M., Muiesan, M. L., Padovani, A., Borroni, B.
• Format: Journal Article
• Language: English
• Published: Milan Springer Milan 01.08.2014; Springer Nature B.V
• Subjects: Aged; Amiodarone - administration & dosage; Amiodarone - therapeutic use; Antacids - administration & dosage; Antacids - therapeutic use; Dementia; DNA Mutational Analysis; Female; Frontotemporal Dementia - drug therapy; Frontotemporal Dementia - genetics; Humans; Intercellular Signaling Peptides and Proteins - blood; Intercellular Signaling Peptides and Proteins - deficiency; Intercellular Signaling Peptides and Proteins - genetics; Male; Medicine; Medicine & Public Health; Middle Aged; Mutation; Neurology; Neuroradiology; Neurosciences; Neurosurgery; Original Article; Pilot Projects; Psychiatry; Sequence Deletion; Treatment Failure; Granulin; Amiodarone; Progranulin; Treatment; Frontotemporal dementia
• ISSN: 1590-1874; 1590-3478; 1590-3478
• DOI: 10.1007/s10072-014-1683-y

Frontotemporal dementia (FTD) is one of the most important neurodegenerative conditions and Granulin ( GRN ) is one of the major genes associated to the disease. FTD-GRN patients are still orphan for any evidence-based target-therapy approach. Interestingly, it has been recently found that alkalizin...