Effects of low-intensity focused ultrasound on the mouse submandibular gland

• Published in: Ultrasound in medicine & biology Vol. 32; no. 4; pp. 587 - 594
• Main Authors: Shuto, Jun, Ichimiya, Issei, Suzuki, Masashi
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.04.2006
• Subjects: Animals; Capillary Permeability; Drug delivery system (DDS); Drug Delivery Systems; Fibrinogen; Fibrinogen - metabolism; Horseradish Peroxidase; Horseradish peroxidase (HRP); Low-intensity focused ultrasound (LIFU); Male; Mice; Mice, Inbred Strains; Microscopy, Confocal; Mouse; Submandibular gland; Submandibular Gland - blood supply; Submandibular Gland - metabolism; Submandibular Gland - pathology; Ultrasonic Therapy - adverse effects; Ultrasonic Therapy - methods; Vessel permeation; Horseradish peroxidase (HRP); Vessel permeation; Mouse; Low-intensity focused ultrasound (LIFU); Fibrinogen; Submandibular gland; Drug delivery system (DDS)

Ultrasound is expected to make a considerable contribution to drug delivery systems (DDSs). We tested the hypothesis that low-intensity focused ultrasound (LIFU) increases vessel permeability in the mouse submandibular gland without causing parenchymal damage. In a preliminary study, LIFU at 3 W/cm...