Home blood pressure-lowering effect of esaxerenone versus trichlormethiazide for uncontrolled hypertension: a predefined subanalysis of the EXCITE-HT randomized controlled trial by basal calcium channel blocker versus angiotensin receptor blocker

• Published in: Hypertension research Vol. 48; no. 2; pp. 506 - 518
• Main Authors: Kario, Kazuomi, Ohbayashi, Hiroyuki, Hashimoto, Masami, Itabashi, Naoki, Kato, Mitsutoshi, Uchiyama, Kazuaki, Hirano, Kunio, Nakamura, Noriko, Miyamoto, Takahide, Nagashima, Hirotaka, Ishida, Hidenori, Ebe, Yusuke, Hatta, Tsuguru, Fukui, Toshiki, Shimosawa, Tatsuo, Katsuya, Tomohiro, Taguchi, Takashi, Tanabe, Ayumi, Ohishi, Mitsuru
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 01.02.2025; Nature Publishing Group
• Subjects: Aged; Angiotensin Receptor Antagonists - therapeutic use; Antihypertensive Agents - therapeutic use; Antihypertensives; Benzoates - therapeutic use; Blood pressure; Blood Pressure - drug effects; Calcium Channel Blockers - therapeutic use; Female; Geriatrics/Gerontology; Health Promotion and Disease Prevention; Humans; Hypertension - drug therapy; Hypertension - physiopathology; Internal Medicine; Male; Medicine; Medicine & Public Health; Middle Aged; Obstetrics/Perinatology/Midwifery; Potassium; Public Health; Pyrroles; Sulfones; Treatment Outcome; Trichlormethiazide - therapeutic use; Essential hypertension; Trichlormethiazide; Calcium channel blockers; Esaxerenone; Angiotensin II receptor blockers

This prespecified subanalysis of the multicenter, randomized, open-label, parallel-group EXCITE-HT study aimed to examine the non-inferiority of esaxerenone to trichlormethiazide as a second-line antihypertensive agent according to the basal antihypertensive agent used (angiotensin receptor blocker...