Kinase Regulation by Hydrophobic Spine Assembly in Cancer

• Published in: Molecular and cellular biology Vol. 35; no. 1; pp. 264 - 276
• Main Authors: Hu, Jiancheng, Ahuja, Lalima G., Meharena, Hiruy S., Kannan, Natarajan, Kornev, Alexandr P., Taylor, Susan S., Shaw, Andrey S.
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.01.2015; American Society for Microbiology
• Subjects: Adenosine Triphosphate - metabolism; Allosteric Site; Catalysis; Gene Expression Regulation, Neoplastic; HEK293 Cells; Histidine - chemistry; Humans; Hydrophobic and Hydrophilic Interactions; Methionine - chemistry; Models, Molecular; Mutation; Neoplasms - enzymology; Phosphotransferases - physiology; Protein Structure, Secondary; Proto-Oncogene Proteins B-raf - genetics; Proto-Oncogene Proteins c-abl - genetics; Receptor, Epidermal Growth Factor - genetics

A new model of kinase regulation based on the assembly of hydrophobic spines has been proposed. Changes in their positions can explain the mechanism of kinase activation. Here, we examined mutations in human cancer for clues about the regulation of the hydrophobic spines by focusing initially on mut...