Autonomous chemical research with large language models

• Published in: Nature (London) Vol. 624; no. 7992; pp. 570 - 578
• Main Authors: Boiko, Daniil A., MacKnight, Robert, Kline, Ben, Gomes, Gabe
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 21.12.2023; Nature Publishing Group
• Subjects: 639/638; 639/705/117; Artificial intelligence; Automation; Chemical research; Chemistry; Couplings; Design; Design of experiments; Documentation; Experimental design; Experiments; Humanities and Social Sciences; Information retrieval; Internet; Laboratories; Language; Large language models; multidisciplinary; Natural language (computers); Nonsteroidal anti-inflammatory drugs; Optimization; Palladium; Planning; Science; Science (multidisciplinary); Software

Transformer-based large language models are making significant strides in various fields, such as natural language processing 1 – 5 , biology 6 , 7 , chemistry 8 – 10 and computer programming 11 , 12 . Here, we show the development and capabilities of Coscientist, an artificial intelligence system d...