TLR1 expression in mouse brain was increased in a KA-induced seizure model

• Published in: Inflammation research Vol. 64; no. 7; pp. 487 - 495
• Main Authors: Wang, Fa-Xiang, Liu, Shi-Yong, Zheng, Xin, Chen, Xin, Lu, Lin-Xiang, Chen, Bin, Xiong, Xiao-yi, Shu, Hai-Feng, Yang, Qing-Wu, Yang, Hui
• Format: Journal Article
• Language: English
• Published: Basel Springer Basel 01.07.2015; Springer Nature B.V
• Subjects: Allergology; Animals; Astrocytes - drug effects; Astrocytes - metabolism; Biomedical and Life Sciences; Biomedicine; Brain Chemistry - genetics; CA1 Region, Hippocampal - drug effects; CA1 Region, Hippocampal - metabolism; Dentate Gyrus - drug effects; Dentate Gyrus - metabolism; Dermatology; Epilepsy, Temporal Lobe - chemically induced; Epilepsy, Temporal Lobe - genetics; Excitatory Amino Acid Agonists; Immunohistochemistry; Immunology; Injections, Intraventricular; Kainic Acid; Mice; Mice, Inbred C57BL; Microglia - drug effects; Microglia - metabolism; Neurology; Neurons - drug effects; Neurons - metabolism; Original Research Paper; Pharmacology/Toxicology; Polymerase Chain Reaction; Rheumatology; RNA, Messenger - biosynthesis; RNA, Messenger - genetics; Seizures - chemically induced; Seizures - genetics; Toll-Like Receptor 1 - biosynthesis; Toll-Like Receptor 1 - genetics; Up-Regulation - drug effects; TLR1; Toll-like receptors; Temporal lobe epilepsy; Status epilepticus

Objective Toll-like receptors (TLRs) that mediate inflammatory responses play an important role in epilepsy; however, whether TLR1 is also involved in epileptogenesis remains unclear. Thus, in this study, we investigated the extent and pattern of TLR1 expression in epileptic tissues. Methods One-hun...