Macrophage-Targeted Berberine-Loaded β-Glucan Nanoparticles Enhance the Treatment of Ulcerative Colitis

• Published in: International journal of nanomedicine Vol. 17; pp. 5303 - 5314
• Main Authors: Xu, Yuying, Huang, Jintao, Fan, Yapei, Long, Haiyue, Liang, Minting, Chen, Qunjie, Wang, Zhiping, Wu, Chaoxi, Wang, Yifei
• Format: Journal Article
• Language: English
• Published: New Zealand Taylor & Francis Ltd 01.01.2022; Dove; Dove Medical Press
• Subjects: Animals; anti-inflammation; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Berberine - pharmacology; Berberine - therapeutic use; beta-Glucans; Cell culture; chiral; Colitis - chemically induced; Colitis, Ulcerative - chemically induced; Colitis, Ulcerative - drug therapy; Cytokines; drug carrier; Drug delivery systems; Drugs; Hemodialysis; immunoregulation; Inflammation - drug therapy; Inflammatory bowel disease; Interleukin-6; Laboratory animals; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred C57BL; Microscopy; Nanoparticles; Original Research; Solvents; Spectrum analysis; Yeast; β-glucan; United Kingdom > UK; United States > US; China; β-glucan; immunoregulation; anti-inflammation; chiral; drug carrier

This study focuses on constructing of an anti-inflammatory drug delivery system by encapsulation of berberine in the β-glucan nanoparticles and evaluates its effect on treating ulcerative colitis. β-Glucan and the anti-inflammatory drug berberine (BER) are self-assembled into nanoparticles to constr...