Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling

• Published in: eLife Vol. 6
• Main Authors: Kedzierski, Lukasz, Tate, Michelle D, Hsu, Alan C, Kolesnik, Tatiana B, Linossi, Edmond M, Dagley, Laura, Dong, Zhaoguang, Freeman, Sarah, Infusini, Giuseppe, Starkey, Malcolm R, Bird, Nicola L, Chatfield, Simon M, Babon, Jeffrey J, Huntington, Nicholas, Belz, Gabrielle, Webb, Andrew, Wark, Peter Ab, Nicola, Nicos A, Xu, Jianqing, Kedzierska, Katherine, Hansbro, Philip M, Nicholson, Sandra E
• Format: Journal Article
• Language: English
• Published: England eLife Sciences Publications Ltd 14.02.2017; eLife Sciences Publications, Ltd
• Subjects: Animals; Body Weight; Cell Biology; Chronic obstructive pulmonary disease; COPD; Cytokines - secretion; Disease Models, Animal; EGFR; Epidermal growth factor; Epidermal growth factor receptors; Epithelial cells; Epithelium; Humans; Inflammation; influenza; Influenza A; Influenza A virus - immunology; innate immunity; Kinases; Mice; Mice, Knockout; Microbiology and Infectious Disease; Mortality; Orthomyxoviridae Infections - pathology; Orthomyxoviridae Infections - virology; PI3K; Receptor, Epidermal Growth Factor - antagonists & inhibitors; Respiratory tract; Signal Transduction; SOCS5; Suppressor of Cytokine Signaling Proteins - deficiency; Suppressor of Cytokine Signaling Proteins - metabolism; Viral infections; Viral Load; influenza; mouse; cell biology; PI3K; innate immunity; infectious disease; microbiology; human; virus; EGFR; COPD; SOCS5

Influenza virus infections have a significant impact on global human health. Individuals with suppressed immunity, or suffering from chronic inflammatory conditions such as COPD, are particularly susceptible to influenza. Here we show that suppressor of cytokine signaling (SOCS) five has a pivotal r...