Cholesterol induction in CD8+ T cell exhaustion in colorectal cancer via the regulation of endoplasmic reticulum-mitochondria contact sites

• Published in: Cancer Immunology, Immunotherapy Vol. 72; no. 12; pp. 4441 - 4456
• Main Authors: Shuwen, Han, Yinhang, Wu, Jing, Zhuang, Qiang, Yan, Yizhen, Jiang, Quan, Qi, Yin, Jin, Jiang, Liu, Xi, Yang
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2023; Springer Nature B.V
• Subjects: Adenomatous polyposis coli; Animal models; Animals; Antigen-presenting cells; Apoptosis; Blood levels; BNIP3 protein; Brief Report; Cancer Research; CD69 antigen; CD8 antigen; CD8-Positive T-Lymphocytes - metabolism; Cell proliferation; Cholecystokinin; Cholesterol; Colon cancer; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - pathology; CTLA-4 protein; Endoplasmic reticulum; Endoplasmic Reticulum Stress; Energy metabolism; Flow cytometry; Humans; Hypercholesterolemia; Hypercholesterolemia - metabolism; Hyperlipidemia; Immunofluorescence; Immunology; Immunoprecipitation; Lipoproteins; Lymphocytes; Lymphocytes T; Medicine; Medicine & Public Health; Mice; Mice, Inbred C57BL; Mitochondria - metabolism; Mitochondria Associated Membranes; Oncology; Protein Tyrosine Phosphatases - metabolism; Proteins; T-Cell Exhaustion; Transmission electron microscopy; Western blotting; γ-Interferon; T-cell exhaustion; CD8; ER-mitochondria contact sites (ERMCs); Endoplasmic reticulum stress (ER stress); Mitochondrial energy metabolism; Colorectal cancer (CRC); Cholesterol; CD8+ T-cell exhaustion

Background Hypercholesterolemia is one of the risk factors for colorectal cancer (CRC). Cholesterol can participate in the regulation of human T cell function and affect the occurrence and development of CRC. Objective To elucidate the pathogenesis of CRC immune escape mediated by CD8 + T cell exhau...